ES2179843T3 - Metodo para la abertura selectiva de capilares de tejido cerebral anormal. - Google Patents
Metodo para la abertura selectiva de capilares de tejido cerebral anormal.Info
- Publication number
- ES2179843T3 ES2179843T3 ES94915822T ES94915822T ES2179843T3 ES 2179843 T3 ES2179843 T3 ES 2179843T3 ES 94915822 T ES94915822 T ES 94915822T ES 94915822 T ES94915822 T ES 94915822T ES 2179843 T3 ES2179843 T3 ES 2179843T3
- Authority
- ES
- Spain
- Prior art keywords
- abnormal brain
- brain tissue
- capillaries
- opening
- capables
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/043—Kallidins; Bradykinins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
METODO PARA ABRIR SELECTIVAMENTE LOS CAPILARES ANORMALES DEL TEJIDO CEREBRAL DE UN MAMIFERO CON EL FIN DE PERMITIR EL PASO SELECTIVO DE AGENTES NEUROFARMACEUTICOS TANTO DE ALTO COMO DE BAJO PESO MOLECULAR AL TEJIDO CEREBRAL ANORMAL. EL METODO UTILIZA LA INFUSION DIRECTA DE BRADIQUININA EN LA ARTERIA CAROTIDA. LA DOSIS DE BRADIQUININA SE MANTIENE A NIVELES QUE PERMITEN LA APERTURA DE LOS CAPILARES DEL CEREBRO ANORMALES SIN ABRIR LOS CAPILARES NORMALES DEL CEREBRO. EL METODO ES UTIL PARA INTRODUCIR UNA AMPLIA VARIEDAD DE AGENTES NEUROFARMACEUTICOS DE FORMA SELECTIVA EN LOS TUMORES CEREBRALES Y OTROS TEJIDOS CEREBRALES ANORMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/059,623 US5434137A (en) | 1993-05-10 | 1993-05-10 | Method for selective opening of abnormal brain tissue capillaries |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179843T3 true ES2179843T3 (es) | 2003-02-01 |
Family
ID=22024161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94915822T Expired - Lifetime ES2179843T3 (es) | 1993-05-10 | 1994-04-19 | Metodo para la abertura selectiva de capilares de tejido cerebral anormal. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5434137A (es) |
EP (1) | EP0698203B1 (es) |
JP (1) | JPH08509978A (es) |
AT (1) | ATE220329T1 (es) |
AU (1) | AU679530B2 (es) |
CA (1) | CA2162055A1 (es) |
DE (1) | DE69430951T2 (es) |
ES (1) | ES2179843T3 (es) |
WO (1) | WO1994027133A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5827819A (en) | 1990-11-01 | 1998-10-27 | Oregon Health Sciences University | Covalent polar lipid conjugates with neurologically active compounds for targeting |
US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
JP2002512592A (ja) * | 1996-11-20 | 2002-04-23 | イスム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ大学 オブ エルサレム | 血液脳関門の通過を可能にする方法及び合成物 |
US6043223A (en) * | 1997-11-12 | 2000-03-28 | The Regents Of The University Of California | Enhanced opening of abnormal brain tissue capillaries |
US6774119B1 (en) * | 1999-04-26 | 2004-08-10 | Cedars-Sinai Medical Center | Herpes simplex virus type 1 (hsv-1)-derived vector for selectively inhibiting malignant cells and methods for its use to treat cancers and to express desired traits in malignant and non-malignant mammalian cells |
US20050153940A1 (en) * | 2000-01-26 | 2005-07-14 | Cedars-Sinai Medical Center | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor |
US7018979B1 (en) | 2000-01-26 | 2006-03-28 | Cedars-Sinai Medical Center | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
WO2002064022A2 (en) * | 2001-02-14 | 2002-08-22 | Duke University | Therapy for cerebral vasospasm |
US7211561B2 (en) * | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
US7045543B2 (en) | 2001-11-05 | 2006-05-16 | Enzrel Inc. | Covalent conjugates of biologically-active compounds with amino acids and amino acid derivatives for targeting to physiologically-protected sites |
US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
US7414076B2 (en) * | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
US20050074506A1 (en) * | 2003-10-02 | 2005-04-07 | Brainsgate Ltd. | Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders |
US20050095196A1 (en) * | 2003-10-29 | 2005-05-05 | Black Keith L. | Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor |
BRPI0517790A (pt) * | 2004-11-12 | 2008-10-21 | Neurochem Int Ltd | métodos e composições fluoradas para tratar doenças relacionadas à amilóide |
US20060167057A1 (en) * | 2004-11-16 | 2006-07-27 | Xianqi Kong | Compounds for the treatment of CNS and amyloid associated diseases |
US8044100B2 (en) * | 2004-12-22 | 2011-10-25 | Bellus Health Inc. | Methods and compositions for treating amyloid-related diseases |
WO2006091542A2 (en) * | 2005-02-22 | 2006-08-31 | Cedars-Sinai Medical Center | Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier |
US20070232556A1 (en) * | 2006-03-31 | 2007-10-04 | Montine Thomas J | Methods and compositions for the treatment of neurological diseases and disorders |
WO2008019394A2 (en) * | 2006-08-11 | 2008-02-14 | The Government Of The United States Of America As Represented By The Secretary, Dept Of Health And Human Services | Methods for treatment and diagnosis of psychiatric disorders |
FI3851447T3 (fi) | 2006-10-12 | 2023-11-15 | Bellus Health Inc | Menetelmiä, yhdisteitä, koostumuksia ja vehikkeleitä 3-amino-1-propaanisulfonihapon vapauttamiseksi |
CA2687106A1 (en) * | 2007-05-16 | 2008-11-20 | Yeda Research And Development Co. Ltd. | Assessment of blood-brain barrier disruption |
CA2736729A1 (en) | 2008-09-29 | 2010-04-01 | Ben Gurion University Of The Negev Research And Development Authority | Amyloid beta-peptides and methods of use thereof |
WO2011021175A2 (en) | 2009-08-18 | 2011-02-24 | Ben Gurion University Of The Negev Research And Development Authority | System and method for analyzing imaging data |
US10275680B2 (en) | 2011-10-19 | 2019-04-30 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Magnetic resonance maps for analyzing tissue |
JP6526627B2 (ja) | 2013-04-24 | 2019-06-05 | テル ハショメール メディカル リサーチ インフラストラクチャー アンド サービシズ リミテッド | 組織解析用の磁気共鳴マップ |
US20180071407A9 (en) * | 2013-09-19 | 2018-03-15 | Tal Burt | Systems and methods for intra-target microdosing (itm) |
WO2018226992A1 (en) | 2017-06-07 | 2018-12-13 | Adrx, Inc. | Tau aggregation inhibitors |
EP3668886A2 (en) | 2017-08-18 | 2020-06-24 | Adrx, Inc. | Tau aggregation peptide inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5112596A (en) * | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
US5268164A (en) * | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
-
1993
- 1993-05-10 US US08/059,623 patent/US5434137A/en not_active Expired - Lifetime
-
1994
- 1994-04-19 ES ES94915822T patent/ES2179843T3/es not_active Expired - Lifetime
- 1994-04-19 AT AT94915822T patent/ATE220329T1/de not_active IP Right Cessation
- 1994-04-19 AU AU67701/94A patent/AU679530B2/en not_active Ceased
- 1994-04-19 CA CA002162055A patent/CA2162055A1/en not_active Abandoned
- 1994-04-19 EP EP94915822A patent/EP0698203B1/en not_active Expired - Lifetime
- 1994-04-19 WO PCT/US1994/004269 patent/WO1994027133A1/en active IP Right Grant
- 1994-04-19 JP JP6525442A patent/JPH08509978A/ja active Pending
- 1994-04-19 DE DE69430951T patent/DE69430951T2/de not_active Expired - Fee Related
-
1995
- 1995-02-16 US US08/389,347 patent/US5527778A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0698203A1 (en) | 1996-02-28 |
DE69430951D1 (de) | 2002-08-14 |
WO1994027133A1 (en) | 1994-11-24 |
DE69430951T2 (de) | 2003-03-27 |
US5527778A (en) | 1996-06-18 |
ATE220329T1 (de) | 2002-07-15 |
CA2162055A1 (en) | 1994-11-24 |
JPH08509978A (ja) | 1996-10-22 |
AU6770194A (en) | 1994-12-12 |
US5434137A (en) | 1995-07-18 |
EP0698203A4 (en) | 1997-02-26 |
AU679530B2 (en) | 1997-07-03 |
EP0698203B1 (en) | 2002-07-10 |
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