ES2178076T3 - Activador de celulas t citotoxicas y su empleo. - Google Patents
Activador de celulas t citotoxicas y su empleo.Info
- Publication number
- ES2178076T3 ES2178076T3 ES98109072T ES98109072T ES2178076T3 ES 2178076 T3 ES2178076 T3 ES 2178076T3 ES 98109072 T ES98109072 T ES 98109072T ES 98109072 T ES98109072 T ES 98109072T ES 2178076 T3 ES2178076 T3 ES 2178076T3
- Authority
- ES
- Spain
- Prior art keywords
- activator
- antigen
- protector
- ctl
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940126530 T cell activator Drugs 0.000 title abstract 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 title 1
- 239000012190 activator Substances 0.000 abstract 5
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 230000001012 protector Effects 0.000 abstract 4
- 239000012790 adhesive layer Substances 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101710194807 Protective antigen Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- LCTXBFGHZLGBNU-UHFFFAOYSA-M amprolium Chemical compound [Cl-].NC1=NC(CCC)=NC=C1C[N+]1=CC=CC=C1C LCTXBFGHZLGBNU-UHFFFAOYSA-M 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940115893 corid Drugs 0.000 abstract 1
- 210000002615 epidermis Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Adhesive Tapes (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
ACTIVADOR CTL, PROTECTOR Y ESPECIFICO DEL ANTIGENO, PREFERENTEMENTE EN FORMA DE EMPLASTO, QUE COMPRENDE EL ANTIGENO PROTECTOR Y UN ESCIPIENTE FARMACEUTICAMENTE ACEPTABLE, UTILIZANDOSE EL ACTIVADOR PARA APLICACION EXTERIOR A UNA SUPERFICIE DE CELULAS DE LANGERHANS EPIDERMICAS, ACTIVADAS POR ALTERACION MECANICA O QUIMICA DE UN ESTRATO CORNEO DE LA EPIDERMIS, EN PARTICULAR UN ACTIVADOR EN EL QUE DICHO EMPLASTO COMPRENDE UN SOPORTE Y UNA CAPA ADHESIVA QUE INCLUYE EL ANTIGENO PROTECTOR DE MANERA LIBERABLE, ENCONTRANDOSE LA CITADA CAPA ADHESIVA LAMINADA SOBRE UN LADO DEL SOPORTE, UN PROCEDIMIENTO PARA ACTIVAR LA CELULA T ASESINA ESPECIFICA DEL ANTIGENO EN UN MAMIFERO, CON EL USO DE DICHO ACTIVADOR Y EL USO DEL CITADO ANTIGENO PROTECTOR PARA LA PRODUCCION DE UN ACTIVADOR DE CELULAS T PROTECTOR Y ESPECIFICO DEL ANTIGENO EN UN MAMIFERO. DADO QUE EL ACTIVADOR DE LAS CTL ESPECIFICO DEL ANTIGENO DE LA INVENCION AMPLIA Y ACTIVA LAS CTL, CON LO QUE SE ERRADICA ESPECIFICAMENTE SOLO LAS CELULAS QUE TIENENUN ANTIGENO PROTECTOR, ES SUMAMENTE UTIL PARA LA PROFILAXIS Y EL TRATAMIENTO DEL CANCER INTRATABLE Y DE ENFERMEDADES PROVOCADAS POR INFECCION VIRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13003197A JP3879785B2 (ja) | 1997-05-20 | 1997-05-20 | キラーｔ細胞賦活剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178076T3 true ES2178076T3 (es) | 2002-12-16 |
Family
ID=15024445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98109072T Expired - Lifetime ES2178076T3 (es) | 1997-05-20 | 1998-05-19 | Activador de celulas t citotoxicas y su empleo. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0891770B1 (es) |
| JP (1) | JP3879785B2 (es) |
| AT (1) | ATE222755T1 (es) |
| CA (1) | CA2238661C (es) |
| DE (1) | DE69807402T2 (es) |
| ES (1) | ES2178076T3 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| EP1165132B1 (en) * | 1999-04-08 | 2011-10-19 | Intercell USA, Inc. | Dry formulation for transcutaneous immunization |
| US9217223B2 (en) | 2005-11-04 | 2015-12-22 | Patrick Johan Olof Ermes Mannius Zu Dem Berge | Method for preparing a textile material and a textile material thus prepared and produced |
| EP2116256A1 (en) | 2007-03-01 | 2009-11-11 | Cosmed Pharmaceutical Co., Ltd. | Transdermal immune preparation, method for production of the same, and transdermal immunization method using the same |
| WO2008136519A1 (ja) | 2007-05-08 | 2008-11-13 | National University Corporation, Hamamatsu University School Of Medicine | Ｅｐ４アゴニストを含有してなる細胞傷害性ｔ細胞の活性化剤 |
| EP2305304A4 (en) | 2008-04-28 | 2011-08-10 | Nat University Corp Hamamatsu University School Of Medicine | IMMUNOSTIMULATOR WITH EP1 AGONIST |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57156414A (en) * | 1981-03-23 | 1982-09-27 | Sekisui Chem Co Ltd | Adhesive tape or sheet for treatment |
| JP3189337B2 (ja) * | 1991-11-08 | 2001-07-16 | 日本電気株式会社 | 皮膚角層の除去器具および除去方法 |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
-
1997
- 1997-05-20 JP JP13003197A patent/JP3879785B2/ja not_active Expired - Fee Related
-
1998
- 1998-05-19 AT AT98109072T patent/ATE222755T1/de not_active IP Right Cessation
- 1998-05-19 EP EP98109072A patent/EP0891770B1/en not_active Expired - Lifetime
- 1998-05-19 CA CA002238661A patent/CA2238661C/en not_active Expired - Fee Related
- 1998-05-19 ES ES98109072T patent/ES2178076T3/es not_active Expired - Lifetime
- 1998-05-19 DE DE69807402T patent/DE69807402T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69807402D1 (de) | 2002-10-02 |
| JPH10316585A (ja) | 1998-12-02 |
| DE69807402T2 (de) | 2003-04-17 |
| JP3879785B2 (ja) | 2007-02-14 |
| EP0891770B1 (en) | 2002-08-28 |
| ATE222755T1 (de) | 2002-09-15 |
| EP0891770A1 (en) | 1999-01-20 |
| CA2238661A1 (en) | 1998-11-20 |
| CA2238661C (en) | 2008-07-22 |
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