ES2172429A1 - Production of purified hydroxy tyrisol comprises three stage chromatography with elution based on a methanol gradient - Google Patents

Production of purified hydroxy tyrisol comprises three stage chromatography with elution based on a methanol gradient

Info

Publication number
ES2172429A1
ES2172429A1 ES200002422A ES200002422A ES2172429A1 ES 2172429 A1 ES2172429 A1 ES 2172429A1 ES 200002422 A ES200002422 A ES 200002422A ES 200002422 A ES200002422 A ES 200002422A ES 2172429 A1 ES2172429 A1 ES 2172429A1
Authority
ES
Spain
Prior art keywords
tyrisol
production
methanol gradient
elution
stage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002422A
Other languages
Spanish (es)
Other versions
ES2172429B1 (en
Inventor
Guzman Juan Fernandez-Bolanos
Moreno Antonia Heredia
Gutierrez Guillermo Rodriguez
Arcos Rocio Rodriguez
Araujo Ana Jimenez
Bejarano Rafael Guillen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES200002422A priority Critical patent/ES2172429B1/en
Priority to ES200100346A priority patent/ES2177457B1/en
Publication of ES2172429A1 publication Critical patent/ES2172429A1/en
Application granted granted Critical
Publication of ES2172429B1 publication Critical patent/ES2172429B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Production of purified hydroxy tyrisol comprises three-stage chromatography employing an XAD adsorbent resin in the first two stages, with elution by water. The third, reverse chromatography stage on polystyrene resin, has elution with a gradient of methanol (25-45%) and purifies the aqueous extract thus obtained.
ES200002422A 2000-10-06 2000-10-06 PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND SUBPRODUCTS DERIVED FROM OLIVE OIL. Expired - Fee Related ES2172429B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES200002422A ES2172429B1 (en) 2000-10-06 2000-10-06 PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND SUBPRODUCTS DERIVED FROM OLIVE OIL.
ES200100346A ES2177457B1 (en) 2000-10-06 2001-02-15 IMPROVEMENTS INTRODUCED IN MAIN PATENT N- 200002422 CONCERNING A PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND BY-PRODUCTS DERIVED FROM THE OLIVE TREE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200002422A ES2172429B1 (en) 2000-10-06 2000-10-06 PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND SUBPRODUCTS DERIVED FROM OLIVE OIL.
ES200100346A ES2177457B1 (en) 2000-10-06 2001-02-15 IMPROVEMENTS INTRODUCED IN MAIN PATENT N- 200002422 CONCERNING A PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND BY-PRODUCTS DERIVED FROM THE OLIVE TREE.

Publications (2)

Publication Number Publication Date
ES2172429A1 true ES2172429A1 (en) 2002-09-16
ES2172429B1 ES2172429B1 (en) 2003-12-16

Family

ID=8495190

Family Applications (2)

Application Number Title Priority Date Filing Date
ES200002422A Expired - Fee Related ES2172429B1 (en) 2000-10-06 2000-10-06 PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND SUBPRODUCTS DERIVED FROM OLIVE OIL.
ES200100346A Expired - Fee Related ES2177457B1 (en) 2000-10-06 2001-02-15 IMPROVEMENTS INTRODUCED IN MAIN PATENT N- 200002422 CONCERNING A PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND BY-PRODUCTS DERIVED FROM THE OLIVE TREE.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES200100346A Expired - Fee Related ES2177457B1 (en) 2000-10-06 2001-02-15 IMPROVEMENTS INTRODUCED IN MAIN PATENT N- 200002422 CONCERNING A PROCEDURE FOR OBTAINING PURIFIED HYDROXYTIROSOL FROM PRODUCTS AND BY-PRODUCTS DERIVED FROM THE OLIVE TREE.

Country Status (1)

Country Link
ES (2) ES2172429B1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007093659A1 (en) * 2006-02-17 2007-08-23 Universidad De Granada Method for the industrial use of tyrosol and hydroxytyrosol contained in the solid by-products of industrial olive crushing
EP2049458A1 (en) 2007-01-26 2009-04-22 Probelte Pharma, S.A. Process and apparatus for the production of hydroxytyrosol containing extract from olives and solids containing residues of olive oil extraction
ES2341526A1 (en) * 2008-12-19 2010-06-21 Consejo Superior De Investigaciones Cientificas (Csic) Method for purifying 3,4-dihydroxyphenylglycol (dhpg) from plant products
WO2018178492A2 (en) 2017-03-31 2018-10-04 Isanatur Spain S.L. Method for obtaining olive oil and at least one extract concentrated in polyphenols and a functional ingredient

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2942224B1 (en) 2009-02-18 2012-11-30 Centre De Cooperation Internationale En Rech Agronomique Pour Le Developpement Cirad PROCESS FOR EXTRACTING PHENOLIC COMPOUNDS FROM WATER OF VEGETATION OF OLIVE AND PREPARATION OF TITLE EXTRACT OF OLIVE AND GRAPE POLYPHENOLS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2143939A1 (en) * 1998-02-26 2000-05-16 Consejo Superior Investigacion Process for obtaining mannitol from pulp extracted from olives
ES2145701A1 (en) * 1998-03-30 2000-07-01 Consejo Superior Investigacion Process for obtaining hydroxytyrosol from olive stones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2143939A1 (en) * 1998-02-26 2000-05-16 Consejo Superior Investigacion Process for obtaining mannitol from pulp extracted from olives
ES2145701A1 (en) * 1998-03-30 2000-07-01 Consejo Superior Investigacion Process for obtaining hydroxytyrosol from olive stones

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FERNáNDEZ-BOLAÑOS, J. et al.: "Hydroxytyrosol and tyrosol as the main compounds found in the phenolic fraction of steam-exploded olive stones", 1998, JAOCS, Vol. 75 (11), paginas 1643-1649, ISSN: 0003-021X, todo el documento. *
VISIOLI, F. et al.: "Waste waters from olive oil production are rich in natural antioxidants", 1995, Experientia, Vol. 51 (1), paginas 32-34, ISSN: 0014-4754, todo el documento. *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007093659A1 (en) * 2006-02-17 2007-08-23 Universidad De Granada Method for the industrial use of tyrosol and hydroxytyrosol contained in the solid by-products of industrial olive crushing
ES2291111A1 (en) * 2006-02-17 2008-02-16 Universidad De Granada Method for the industrial use of tyrosol and hydroxytyrosol contained in the solid by-products of industrial olive crushing
EP2049458A1 (en) 2007-01-26 2009-04-22 Probelte Pharma, S.A. Process and apparatus for the production of hydroxytyrosol containing extract from olives and solids containing residues of olive oil extraction
EP2049458B1 (en) * 2007-01-26 2013-12-25 Probelte Pharma, S.A. Process for the production of hydroxytyrosol containing extract from olives and solids containing residues of olive oil extraction
ES2341526A1 (en) * 2008-12-19 2010-06-21 Consejo Superior De Investigaciones Cientificas (Csic) Method for purifying 3,4-dihydroxyphenylglycol (dhpg) from plant products
WO2010070168A1 (en) * 2008-12-19 2010-06-24 Consejo Superior De Investigaciones Científicas (Csic) Method for purifying 3,4-dihydroxyphenylglycol (dhpg) from plant products
WO2018178492A2 (en) 2017-03-31 2018-10-04 Isanatur Spain S.L. Method for obtaining olive oil and at least one extract concentrated in polyphenols and a functional ingredient
US11052123B2 (en) 2017-03-31 2021-07-06 Isanatur Spain S.L. Method of obtaining olive oil and extracts from olives

Also Published As

Publication number Publication date
ES2177457B1 (en) 2004-09-16
ES2172429B1 (en) 2003-12-16
ES2177457A1 (en) 2002-12-01

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