ES2172359B1 - PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT. - Google Patents

PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT.

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Publication number
ES2172359B1
ES2172359B1 ES9900232A ES9900232A ES2172359B1 ES 2172359 B1 ES2172359 B1 ES 2172359B1 ES 9900232 A ES9900232 A ES 9900232A ES 9900232 A ES9900232 A ES 9900232A ES 2172359 B1 ES2172359 B1 ES 2172359B1
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ES
Spain
Prior art keywords
subunit
subunity
peptide
obtaining
polyclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9900232A
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Spanish (es)
Other versions
ES2172359A1 (en
Inventor
Almau Carlos Matute
Fogarty David James
Cerda Fernando Perez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euskal Herriko Unibertsitatea
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Euskal Herriko Unibertsitatea
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Priority to ES9900232A priority Critical patent/ES2172359B1/en
Publication of ES2172359A1 publication Critical patent/ES2172359A1/en
Application granted granted Critical
Publication of ES2172359B1 publication Critical patent/ES2172359B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Péptido capaz de inducir anticuerpos contra la subunidad KA1 de los receptores de kainato de mamíferos, anticuerpo policlonal contra dicha subunidad KA1 y un procedimiento para su obtención. El péptido comprende una secuencia de aminoácidos derivada del extremo carboxilo de la secuencia de aminoácidos constitutiva de una subunidad KA1 de un receptor de kainato en un mamífero que (i) está altamente conservada entre al menos dos homólogos de la subunidad KA1 de distintas especies de mamífero, y (ii) no comparte una homología importante con otras sub- unidades pertenecientes al subtipo de receptores de kainato pertenecientes a la familia de receptores de glutamato. Los anticuerpos policlonales pueden obtenerse por inmunización de animales con dichos péptidos y purificación del antisuero por afinidad frente al péptido inmunizante inmovilizado. Estos anticuerpos son útiles para localizar la subunidad KA1 en tejidos, particularmente en cerebros normales y patológicos. De aplicación en Investigación básica y clínica (Neuropatología).Peptide capable of inducing antibodies against the KA1 subunit of mammalian kainate receptors, polyclonal antibody against said KA1 subunit and a method for obtaining it. The peptide comprises an amino acid sequence derived from the carboxyl end of the amino acid sequence constituting a KA1 subunit of a kainate receptor in a mammal that (i) is highly conserved between at least two homologues of the KA1 subunit of different mammalian species , and (ii) does not share an important homology with other sub-units belonging to the subtype of kainate receptors belonging to the glutamate receptor family. Polyclonal antibodies can be obtained by immunization of animals with said peptides and purification of the antiserum by affinity against the immobilized immunizing peptide. These antibodies are useful for locating the KA1 subunit in tissues, particularly in normal and pathological brains. Application in Basic and Clinical Research (Neuropathology)

ES9900232A 1999-02-04 1999-02-04 PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT. Expired - Fee Related ES2172359B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9900232A ES2172359B1 (en) 1999-02-04 1999-02-04 PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900232A ES2172359B1 (en) 1999-02-04 1999-02-04 PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT.

Publications (2)

Publication Number Publication Date
ES2172359A1 ES2172359A1 (en) 2002-09-16
ES2172359B1 true ES2172359B1 (en) 2003-11-01

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ES9900232A Expired - Fee Related ES2172359B1 (en) 1999-02-04 1999-02-04 PEPTIDE ABLE TO INDUCE ANTIBODIES AGAINST KA1 SUBUNITY OF KAINATO RECIPIENTS OF MAMMALS, POLYCLONAL ANTIBODY AGAINST SUCH SUBUNITY KA1 AND A PROCEDURE FOR OBTAINING IT.

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ES (1) ES2172359B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0529994T3 (en) * 1991-08-26 2001-04-30 Nps Allelix Corp Human KA-1 receptor, a rabbit high-affinity receptor of the EAA1 family (excitatory amino acids)
CA2105804C (en) * 1992-09-17 2003-04-29 Rajender Kamboj Kainate-binding, human cns receptors of the eaa5 family

Also Published As

Publication number Publication date
ES2172359A1 (en) 2002-09-16

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