ES2170654A1 - Application of gamma globulin-rich plasma proteins of animal origin for the preparation of medicinal compositions, food and dietary preparations to prevent and treat specific disorders in human beings and animals - Google Patents

Application of gamma globulin-rich plasma proteins of animal origin for the preparation of medicinal compositions, food and dietary preparations to prevent and treat specific disorders in human beings and animals

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Publication number
ES2170654A1
ES2170654A1 ES200000933A ES200000933A ES2170654A1 ES 2170654 A1 ES2170654 A1 ES 2170654A1 ES 200000933 A ES200000933 A ES 200000933A ES 200000933 A ES200000933 A ES 200000933A ES 2170654 A1 ES2170654 A1 ES 2170654A1
Authority
ES
Spain
Prior art keywords
mixture
gamma globulin
preparation
animal origin
plasma proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000933A
Other languages
Spanish (es)
Other versions
ES2170654B1 (en
Inventor
Pozo Francisco J Polo
Canel Carmen Rodriguez
Navarro Jesus Rodenas
Martin Maria Nieves Saborido
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APC Europe SA
Original Assignee
APC Europe SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by APC Europe SA filed Critical APC Europe SA
Priority to EP00500066A priority Critical patent/EP1044690B1/en
Priority to ES00500066T priority patent/ES2243223T3/en
Priority to DE60021644T priority patent/DE60021644D1/en
Priority to AT00500066T priority patent/ATE300956T1/en
Publication of ES2170654A1 publication Critical patent/ES2170654A1/en
Application granted granted Critical
Publication of ES2170654B1 publication Critical patent/ES2170654B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Mixtures of gamma globulin-rich plasma proteins of animal origin are used for the preparation of medicinal compositions, food and dietary preparations for the prevention and treatment of specific disorders in human beings and animals. Application of mixtures of gamma globulin-rich plasma proteins of animal origin having a gamma globulin content of more than 25 wt.%, for the preparation of medicinal compositions, food and dietary preparations suitable for human beings and animals (a) in the prevention and treatment of gastrointestinal disorders, (b) for improving the immunological state, (c) for the treatment of malabsorption processes, and (d) for the treatment of clinical conditions. An Independent claim is also included for a processes for the preparation of mixtures of plasma proteins of animal origin having a gamma globulin content of more than 90 wt.%, without the use of chromatographic columns, from a first concentrate, its gamma globulin/proteins ratio is more than 30 wt.%, in which the first concentrate is derived from animal plasma which has been subjected to prior centrifugation operation(s). The first concentrate is diluted in water in a first concentrate: water ratio of 1:7 - 1:11, giving a first mixture. The pH of the first mixture is adjusted for the first time to 3-6, to give a second mixture. Polyethylene glycol (2-6 wt.%) is added relative to the second mixture, giving a third mixture. The third mixture is centrifuged for a first time at 3000 - 11000 g, giving a first insolubilized beta globulin-rich fraction and a first clarified gamma globulin-rich fraction, both first fractions are separated. The pH of the gamma globulin-rich fraction is adjusted for a second time from 6-9 to give a fourth mixture, to which polyethylene glycol is added to a weight proportion of 6-12 wt.% relative to the fourth mixture, to provide a fifth mixture. The fifth mixture is centrifuged for a second time at an acceleration of 3000 - 1000 g to give a second insolubilized fraction composed mainly of gamma globulin and a second clarified fraction, both second fractions are separated.
ES200000933A 1999-04-13 2000-04-11 IMPROVEMENTS INTRODUCED IN THE OBJECT OF PATENT P9900757, BY A PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS. Expired - Fee Related ES2170654B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00500066A EP1044690B1 (en) 1999-04-13 2000-04-12 Applications of gamma globulin-rich plasma protein mixtures of animal origin and process for the preparation thereof
ES00500066T ES2243223T3 (en) 1999-04-13 2000-04-12 APPLICATIONS OF MIXTURES OF PLASMATIC PROTEINS OF ANIMAL ORIGIN IN GAMMAGLOBULINES AND PROCEDURE FOR THEIR PREPARATION.
DE60021644T DE60021644D1 (en) 1999-04-13 2000-04-12 Application and method of preparation of animal gamma globulin-rich plasma protein mixtures
AT00500066T ATE300956T1 (en) 1999-04-13 2000-04-12 APPLICATION AND PRODUCTION PROCESS OF ANIMAL GAMMAGLOBULIN-RICH PLASMA PROTEIN MIXTURES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9900757A ES2158776B1 (en) 1999-04-13 1999-04-13 PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS.

Publications (2)

Publication Number Publication Date
ES2170654A1 true ES2170654A1 (en) 2002-08-01
ES2170654B1 ES2170654B1 (en) 2003-06-16

Family

ID=8308004

Family Applications (2)

Application Number Title Priority Date Filing Date
ES9900757A Expired - Fee Related ES2158776B1 (en) 1999-04-13 1999-04-13 PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS.
ES200000933A Expired - Fee Related ES2170654B1 (en) 1999-04-13 2000-04-11 IMPROVEMENTS INTRODUCED IN THE OBJECT OF PATENT P9900757, BY A PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES9900757A Expired - Fee Related ES2158776B1 (en) 1999-04-13 1999-04-13 PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS.

Country Status (1)

Country Link
ES (2) ES2158776B1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064210A1 (en) * 1981-05-01 1982-11-10 Miles Inc. Oral pharmaceutical composition containing immune globulin
EP0338229A1 (en) * 1988-04-19 1989-10-25 Biotest Pharma Gmbh Preparation with antibody activity and a large spectrum of action, remedy consisting of or containing it and its use for the treatment of bacterial or toxin-induced diseases and for combatting protozoa
US5122373A (en) * 1983-03-16 1992-06-16 Immuno Aktiengesellschaft Immunoglobulin-g-containing fraction
US5531989A (en) * 1994-10-28 1996-07-02 Metagenics, Inc. Immunoglobulin and fiber-containing composition for human gastrointestinal health
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2672303B2 (en) * 1987-06-22 1997-11-05 財団法人 化学及血清療法研究所 Infection prevention and treatment for horses
JP2613409B2 (en) * 1987-11-20 1997-05-28 株式会社ミドリ十字 Method for producing anti-AIDS virus antibody-positive intravenous immunoglobulin preparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0064210A1 (en) * 1981-05-01 1982-11-10 Miles Inc. Oral pharmaceutical composition containing immune globulin
US5122373A (en) * 1983-03-16 1992-06-16 Immuno Aktiengesellschaft Immunoglobulin-g-containing fraction
EP0338229A1 (en) * 1988-04-19 1989-10-25 Biotest Pharma Gmbh Preparation with antibody activity and a large spectrum of action, remedy consisting of or containing it and its use for the treatment of bacterial or toxin-induced diseases and for combatting protozoa
US5531989A (en) * 1994-10-28 1996-07-02 Metagenics, Inc. Immunoglobulin and fiber-containing composition for human gastrointestinal health
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Also Published As

Publication number Publication date
ES2170654B1 (en) 2003-06-16
ES2158776B1 (en) 2002-03-16
ES2158776A1 (en) 2001-09-01

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