ES2170654A1 - Application of gamma globulin-rich plasma proteins of animal origin for the preparation of medicinal compositions, food and dietary preparations to prevent and treat specific disorders in human beings and animals - Google Patents
Application of gamma globulin-rich plasma proteins of animal origin for the preparation of medicinal compositions, food and dietary preparations to prevent and treat specific disorders in human beings and animalsInfo
- Publication number
- ES2170654A1 ES2170654A1 ES200000933A ES200000933A ES2170654A1 ES 2170654 A1 ES2170654 A1 ES 2170654A1 ES 200000933 A ES200000933 A ES 200000933A ES 200000933 A ES200000933 A ES 200000933A ES 2170654 A1 ES2170654 A1 ES 2170654A1
- Authority
- ES
- Spain
- Prior art keywords
- mixture
- gamma globulin
- preparation
- animal origin
- plasma proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Mixtures of gamma globulin-rich plasma proteins of animal origin are used for the preparation of medicinal compositions, food and dietary preparations for the prevention and treatment of specific disorders in human beings and animals. Application of mixtures of gamma globulin-rich plasma proteins of animal origin having a gamma globulin content of more than 25 wt.%, for the preparation of medicinal compositions, food and dietary preparations suitable for human beings and animals (a) in the prevention and treatment of gastrointestinal disorders, (b) for improving the immunological state, (c) for the treatment of malabsorption processes, and (d) for the treatment of clinical conditions. An Independent claim is also included for a processes for the preparation of mixtures of plasma proteins of animal origin having a gamma globulin content of more than 90 wt.%, without the use of chromatographic columns, from a first concentrate, its gamma globulin/proteins ratio is more than 30 wt.%, in which the first concentrate is derived from animal plasma which has been subjected to prior centrifugation operation(s). The first concentrate is diluted in water in a first concentrate: water ratio of 1:7 - 1:11, giving a first mixture. The pH of the first mixture is adjusted for the first time to 3-6, to give a second mixture. Polyethylene glycol (2-6 wt.%) is added relative to the second mixture, giving a third mixture. The third mixture is centrifuged for a first time at 3000 - 11000 g, giving a first insolubilized beta globulin-rich fraction and a first clarified gamma globulin-rich fraction, both first fractions are separated. The pH of the gamma globulin-rich fraction is adjusted for a second time from 6-9 to give a fourth mixture, to which polyethylene glycol is added to a weight proportion of 6-12 wt.% relative to the fourth mixture, to provide a fifth mixture. The fifth mixture is centrifuged for a second time at an acceleration of 3000 - 1000 g to give a second insolubilized fraction composed mainly of gamma globulin and a second clarified fraction, both second fractions are separated.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00500066A EP1044690B1 (en) | 1999-04-13 | 2000-04-12 | Applications of gamma globulin-rich plasma protein mixtures of animal origin and process for the preparation thereof |
ES00500066T ES2243223T3 (en) | 1999-04-13 | 2000-04-12 | APPLICATIONS OF MIXTURES OF PLASMATIC PROTEINS OF ANIMAL ORIGIN IN GAMMAGLOBULINES AND PROCEDURE FOR THEIR PREPARATION. |
DE60021644T DE60021644D1 (en) | 1999-04-13 | 2000-04-12 | Application and method of preparation of animal gamma globulin-rich plasma protein mixtures |
AT00500066T ATE300956T1 (en) | 1999-04-13 | 2000-04-12 | APPLICATION AND PRODUCTION PROCESS OF ANIMAL GAMMAGLOBULIN-RICH PLASMA PROTEIN MIXTURES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9900757A ES2158776B1 (en) | 1999-04-13 | 1999-04-13 | PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2170654A1 true ES2170654A1 (en) | 2002-08-01 |
ES2170654B1 ES2170654B1 (en) | 2003-06-16 |
Family
ID=8308004
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9900757A Expired - Fee Related ES2158776B1 (en) | 1999-04-13 | 1999-04-13 | PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS. |
ES200000933A Expired - Fee Related ES2170654B1 (en) | 1999-04-13 | 2000-04-11 | IMPROVEMENTS INTRODUCED IN THE OBJECT OF PATENT P9900757, BY A PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9900757A Expired - Fee Related ES2158776B1 (en) | 1999-04-13 | 1999-04-13 | PROCEDURE FOR OBTAINING GAMMAGLOBULINS OF ANIMAL ORIGIN AND CORRESPONDING APPLICATIONS. |
Country Status (1)
Country | Link |
---|---|
ES (2) | ES2158776B1 (en) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064210A1 (en) * | 1981-05-01 | 1982-11-10 | Miles Inc. | Oral pharmaceutical composition containing immune globulin |
EP0338229A1 (en) * | 1988-04-19 | 1989-10-25 | Biotest Pharma Gmbh | Preparation with antibody activity and a large spectrum of action, remedy consisting of or containing it and its use for the treatment of bacterial or toxin-induced diseases and for combatting protozoa |
US5122373A (en) * | 1983-03-16 | 1992-06-16 | Immuno Aktiengesellschaft | Immunoglobulin-g-containing fraction |
US5531989A (en) * | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
WO1999064462A1 (en) * | 1998-06-09 | 1999-12-16 | Statens Serum Institut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2672303B2 (en) * | 1987-06-22 | 1997-11-05 | 財団法人 化学及血清療法研究所 | Infection prevention and treatment for horses |
JP2613409B2 (en) * | 1987-11-20 | 1997-05-28 | 株式会社ミドリ十字 | Method for producing anti-AIDS virus antibody-positive intravenous immunoglobulin preparation |
-
1999
- 1999-04-13 ES ES9900757A patent/ES2158776B1/en not_active Expired - Fee Related
-
2000
- 2000-04-11 ES ES200000933A patent/ES2170654B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0064210A1 (en) * | 1981-05-01 | 1982-11-10 | Miles Inc. | Oral pharmaceutical composition containing immune globulin |
US5122373A (en) * | 1983-03-16 | 1992-06-16 | Immuno Aktiengesellschaft | Immunoglobulin-g-containing fraction |
EP0338229A1 (en) * | 1988-04-19 | 1989-10-25 | Biotest Pharma Gmbh | Preparation with antibody activity and a large spectrum of action, remedy consisting of or containing it and its use for the treatment of bacterial or toxin-induced diseases and for combatting protozoa |
US5531989A (en) * | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
WO1999064462A1 (en) * | 1998-06-09 | 1999-12-16 | Statens Serum Institut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
Also Published As
Publication number | Publication date |
---|---|
ES2170654B1 (en) | 2003-06-16 |
ES2158776B1 (en) | 2002-03-16 |
ES2158776A1 (en) | 2001-09-01 |
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