ES2166071T3 - Procedimiento para purificar k-252a. - Google Patents

Procedimiento para purificar k-252a.

Info

Publication number
ES2166071T3
ES2166071T3 ES97914579T ES97914579T ES2166071T3 ES 2166071 T3 ES2166071 T3 ES 2166071T3 ES 97914579 T ES97914579 T ES 97914579T ES 97914579 T ES97914579 T ES 97914579T ES 2166071 T3 ES2166071 T3 ES 2166071T3
Authority
ES
Spain
Prior art keywords
purify
procedure
alkal
convert
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97914579T
Other languages
English (en)
Inventor
Satoru Nagamura
Mitsutaka Kino
Tadashi Kinoshita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2166071T3 publication Critical patent/ES2166071T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/80—Elimination or reduction of contamination by undersired ferments, e.g. aseptic cultivation

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Lasers (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPONE UN PROCESO DE PURIFICACION DE K 252A, QUE INCLUYE: TRATAMIENTO DE LOS MICROORGANISMOS QUE CONTIENEN K UNA SOLUCION ALCALINA PARA CONVERTIR K RESENTADO MEDIANTE LA FORMULA (II): O SALES ALCALINAS DEL MISMO, QUE DESPUES SE EXPULSAN DE LAS CELULAS, METILACION DE K 52B O DE LAS SALES ALCALINAS DEL MISMO PARA CONVERTIRLAS NUEVAMENTE EN K ESULTANTE.
ES97914579T 1996-04-09 1997-04-02 Procedimiento para purificar k-252a. Expired - Lifetime ES2166071T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8646996 1996-04-09

Publications (1)

Publication Number Publication Date
ES2166071T3 true ES2166071T3 (es) 2002-04-01

Family

ID=13887827

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97914579T Expired - Lifetime ES2166071T3 (es) 1996-04-09 1997-04-02 Procedimiento para purificar k-252a.

Country Status (11)

Country Link
US (1) US6004801A (es)
EP (1) EP0834574B1 (es)
JP (1) JP3865781B2 (es)
AT (1) ATE207127T1 (es)
AU (1) AU2177497A (es)
CA (1) CA2228471C (es)
DE (1) DE69707389T2 (es)
DK (1) DK0834574T3 (es)
ES (1) ES2166071T3 (es)
PT (1) PT834574E (es)
WO (1) WO1997038120A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723844B1 (en) * 2003-02-27 2004-04-20 Abbott Laboratories Preparation of K-252a

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6041489A (ja) * 1983-08-12 1985-03-05 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ―２５２

Also Published As

Publication number Publication date
PT834574E (pt) 2002-04-29
DK0834574T3 (da) 2001-12-27
JP3865781B2 (ja) 2007-01-10
AU2177497A (en) 1997-10-29
EP0834574A1 (en) 1998-04-08
EP0834574A4 (es) 1998-05-20
ATE207127T1 (de) 2001-11-15
CA2228471C (en) 2005-05-24
DE69707389T2 (de) 2002-06-27
CA2228471A1 (en) 1997-10-16
US6004801A (en) 1999-12-21
EP0834574B1 (en) 2001-10-17
DE69707389D1 (de) 2001-11-22
WO1997038120A1 (fr) 1997-10-16
MX9709802A (es) 1998-07-31

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