ES2165711T3 - RIGIDIFIED CYANINE TRIMETIN COLORS. - Google Patents

RIGIDIFIED CYANINE TRIMETIN COLORS.

Info

Publication number
ES2165711T3
ES2165711T3 ES98963218T ES98963218T ES2165711T3 ES 2165711 T3 ES2165711 T3 ES 2165711T3 ES 98963218 T ES98963218 T ES 98963218T ES 98963218 T ES98963218 T ES 98963218T ES 2165711 T3 ES2165711 T3 ES 2165711T3
Authority
ES
Spain
Prior art keywords
atoms
groups
optionally
radical
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98963218T
Other languages
Spanish (es)
Inventor
Alan S Waggoner
Ratnakar B Mujumdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carnegie Mellon University
Original Assignee
Carnegie Mellon University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Mellon University filed Critical Carnegie Mellon University
Application granted granted Critical
Publication of ES2165711T3 publication Critical patent/ES2165711T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

Disclosed are analogues of trimethine cyanine dyes which are useful for imparting fluorescent properties to target materials by covalent and non-covalent association. The compounds have general formula (2) optionally substituted by groups R<2>-R<9 >wherein groups R<6>, R<7>, R<8 >and R<9 >are attached to the rings containing X and Y or, optionally are attached to atoms of the Z<a >and Z<b >ring structures and groups R<1>-R<9 >are chosen to provide desired solubility, reactivity and spectralproperties to the fluorescent compounds; A is selected from O, S and NR<11 >where R<11 >is the substituted amino radical (a), where R' is selected from hydrogen, a C1-4 alkyl and aryl and R'' is selected from C1-18 alkyl, aryl, heteroaryl, an acyl radical having from 2-7 carbon atoms, and a thiocarbamoyl radical; Z<a >and Z<b >each represent a bond or the atoms necessary to complete one, two fused or three fused aromatic rings each ring having five or six atoms, selected from carbon atoms and, optionally, non more than two oxygen, nitrogen and sulphur atoms.
ES98963218T 1997-12-17 1998-12-16 RIGIDIFIED CYANINE TRIMETIN COLORS. Expired - Lifetime ES2165711T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99221297A 1997-12-17 1997-12-17

Publications (1)

Publication Number Publication Date
ES2165711T3 true ES2165711T3 (en) 2002-03-16

Family

ID=25538049

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98963218T Expired - Lifetime ES2165711T3 (en) 1997-12-17 1998-12-16 RIGIDIFIED CYANINE TRIMETIN COLORS.

Country Status (10)

Country Link
US (1) US6686145B1 (en)
EP (1) EP1042407B1 (en)
JP (1) JP4927253B2 (en)
AT (1) ATE205515T1 (en)
AU (1) AU760598B2 (en)
CA (1) CA2314188C (en)
DE (1) DE69801682T2 (en)
DK (1) DK1042407T3 (en)
ES (1) ES2165711T3 (en)
WO (1) WO1999031181A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
EP1196398A4 (en) * 1999-07-06 2002-11-06 Surromed Inc Bridged fluorescent dyes, their preparation and their use in assays
DE19937024A1 (en) * 1999-08-05 2001-02-08 Bayer Ag Use of acylsulfonamido substituted polymethine dyes as fluorescent dyes and / or markers
EP1223197B1 (en) 2001-01-03 2012-08-08 Visen Medical, Inc. Symmetric, monofunctionalised polymethine dyes labelling reagents
EP1221465A1 (en) 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
EP2258776A1 (en) * 2002-05-10 2010-12-08 Carnegie Mellon University Fluorescent cyanine dyes containing functional groups
EP1781675B1 (en) 2004-08-13 2014-03-26 Epoch Biosciences, Inc. Phosphonate fluorescent dyes and conjugates
FR2875131B1 (en) * 2004-09-13 2007-09-28 Oreal COMPOSITION COMPRISING AT LEAST ONE SUBSTITUTED CARBOCYANINE DERIVATIVE, PROCESS FOR TREATING KERATIN FIBERS USING THE SAME, DEVICE AND USE
US7419511B2 (en) 2004-09-13 2008-09-02 L'oreal, S.A. Compositions comprising at least one substituted carbocyanin derivative, processes for treating keratin fibers using them, device therefor and uses thereof
US7425221B2 (en) 2004-09-13 2008-09-16 L'oreal S.A. Composition comprising at least one substituted derivative of carbocyanine, method for treating keratin fibers using it, device and use
US7427301B2 (en) 2004-09-13 2008-09-23 L'ORéAL S.A. Composition comprising at least one substituted carbocyanin derivative, process for treating keratin fibers using it, device therefor and use thereof
EP1794237A2 (en) 2004-09-30 2007-06-13 GE Healthcare UK Limited Fluorescent nucleotide analogues
US7282373B2 (en) 2004-12-23 2007-10-16 Rutgers, The State University Of New Jersey Ultra-high specificity fluorescent labeling
US7381572B2 (en) 2004-12-23 2008-06-03 Rutgers, The State University Of New Jersey Reagents and procedures for multi-label high-specificity labeling
US20060207881A1 (en) * 2005-02-01 2006-09-21 Sigma-Aldrich Co. Detection of polyamino acids using trimethincyanine dyes
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
ES2612738T3 (en) 2005-09-02 2017-05-18 Visen Medical, Inc. Biocompatible fluorescent imaging agents
EP1934202B1 (en) 2005-09-02 2019-01-09 Visen Medical, Inc. Nicotinic acid and picolinic acid derived near-infrared fluorophores
CA2621137C (en) 2005-09-02 2014-07-29 Visen Medical, Inc. Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels
ES2606333T3 (en) * 2005-11-28 2017-03-23 Dako Denmark A/S Cyanine dyes and methods to detect a target using such dyes
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
KR20110100679A (en) 2009-01-13 2011-09-14 글락소 그룹 리미티드 Pyrimidinecarboxamide derivatives as inhibitors of syk kinase
GB201007203D0 (en) 2010-04-29 2010-06-16 Glaxo Group Ltd Novel compounds
US10041950B2 (en) 2012-03-27 2018-08-07 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
KR102502117B1 (en) * 2015-07-16 2023-02-22 에스에프씨 주식회사 Dye compounds
US10994029B2 (en) 2017-08-24 2021-05-04 The Usa, As Represented By The Secretary, Department Of Health And Human Services Conformational restriction of cyanine fluorophores in far-red and near-IR range
KR102593166B1 (en) * 2017-11-23 2023-10-25 에스에프씨 주식회사 Labeling dye and labeling kit comprising the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915715A (en) 1970-08-13 1975-10-28 Eastman Kodak Co Silver halide photographic materials containing a high weight ratio of gold to sulfur sensitizers and a sensitizing methine dye
US3753721A (en) 1970-08-13 1973-08-21 Eastman Kodak Co Photographic materials
US3821233A (en) 1970-10-30 1974-06-28 Eastman Kodak Co Rigidized carbocyanine dyes containing a pyrida-dipyridinium nucleus
US3854956A (en) 1970-10-30 1974-12-17 Eastman Kodak Co Dyestuffs and spectral sensitizers for silver halide
US3679427A (en) * 1970-10-30 1972-07-25 Eastman Kodak Co Rigidized carbocyanine dyes and photographic emulsions
US3864644A (en) 1971-03-22 1975-02-04 Eastman Kodak Co Dye lasers including rigidized carbocyanine dyes
CA985493A (en) 1971-03-22 1976-03-16 Eastman Kodak Company Dye lasers including rigidized carbocyanine dyes
US3904637A (en) 1972-04-19 1975-09-09 Eastman Kodak Co 7'a'h,8'a'h-bisbenzothiazolo(3,2-a;-3',2'-a)pyrano (3,2-c;5,6-c'+9 dipyridinium compounds and related derivatives thereof
DE69624623T2 (en) 1995-06-07 2003-07-24 Univ Pittsburgh Carnegie Mello Stiffened monomethine cyanine dyes
US5658735A (en) 1995-11-09 1997-08-19 Biometric Imaging, Inc. Cyclized fluorescent nucleic acid intercalating cyanine dyes and nucleic acid detection methods
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes

Also Published As

Publication number Publication date
CA2314188A1 (en) 1999-06-24
ATE205515T1 (en) 2001-09-15
DK1042407T3 (en) 2001-12-27
JP2002508428A (en) 2002-03-19
US6686145B1 (en) 2004-02-03
AU760598B2 (en) 2003-05-15
CA2314188C (en) 2009-11-17
EP1042407A1 (en) 2000-10-11
WO1999031181A1 (en) 1999-06-24
AU1828899A (en) 1999-07-05
DE69801682D1 (en) 2001-10-18
JP4927253B2 (en) 2012-05-09
DE69801682T2 (en) 2002-06-20
EP1042407B1 (en) 2001-09-12

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