ES2164474T3 - Acido alfa-lipoico en forma cristalina. - Google Patents

Acido alfa-lipoico en forma cristalina.

Info

Publication number
ES2164474T3
ES2164474T3 ES99104155T ES99104155T ES2164474T3 ES 2164474 T3 ES2164474 T3 ES 2164474T3 ES 99104155 T ES99104155 T ES 99104155T ES 99104155 T ES99104155 T ES 99104155T ES 2164474 T3 ES2164474 T3 ES 2164474T3
Authority
ES
Spain
Prior art keywords
alpha
lipoic acid
crystal form
charmers
difractogram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99104155T
Other languages
English (en)
Inventor
Thomas Dr Beisswenger
Eberhard Oestreich
Karl-Friedrich Dr Landgraf
Gunter Dr Laban
Matthias Dr Rischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Application granted granted Critical
Publication of ES2164474T3 publication Critical patent/ES2164474T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Abstract

LA INVENCION TRATA DE UN ACIDO ALFA - LIPOICO CON UNA PROPORCION IMPORTANTE DE UN ENANTIOMERO Y DE NUEVA MODIFICACION, TENIENDO EL DIFRACTOGRAMA DEL POLVO A LOS RAYOS X UN REFLEJO CARACTERISTICO ENTRE 23,4 HASTA 22,7 2THETA (CU), QUE SE DESP LAZA CUANDO AUMENTA EL CONTENIDO EN ENANTIOMEROS EN DIRECCION DE LOS VALORES ANGULARES MAS PEQUEÑOS.
ES99104155T 1998-03-11 1999-03-02 Acido alfa-lipoico en forma cristalina. Expired - Lifetime ES2164474T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19810336A DE19810336A1 (de) 1998-03-11 1998-03-11 Alpha-Liponsäure mit neuartiger Modifikation
US09/074,645 US5994393A (en) 1998-03-11 1998-05-08 Alpha-lipoic acid with novel modification

Publications (1)

Publication Number Publication Date
ES2164474T3 true ES2164474T3 (es) 2002-02-16

Family

ID=26044524

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99104155T Expired - Lifetime ES2164474T3 (es) 1998-03-11 1999-03-02 Acido alfa-lipoico en forma cristalina.

Country Status (10)

Country Link
US (1) US5994393A (es)
EP (1) EP0949258B1 (es)
AT (1) ATE207914T1 (es)
CA (1) CA2265276C (es)
CY (1) CY1106435T1 (es)
DE (2) DE19810336A1 (es)
DK (1) DK0949258T3 (es)
ES (1) ES2164474T3 (es)
IN (1) IN186598B (es)
PT (1) PT949258E (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
ATE320833T1 (de) * 2000-06-06 2006-04-15 Verwendung von einem liponsaüren -(r)- enantiomeren in kosmetika und dermatologie
DE10151764A1 (de) * 2001-10-19 2003-05-08 Basf Ag Kombination von Liponsäure und Glutamin in Lebens- und Arzneimitteln
BRPI0518580A2 (pt) * 2004-11-24 2008-11-25 Hills Pet Nutrition Inc mÉtodo para melhorar a depuraÇço hepÁtica de substÂncias xenobiàticas em um animal, kit adequado para alimentar Ácido lipàico a um animal, meio para comunicar informaÇço, composiÇço, e, uso da composiÇço que compreende Ácido lipàico
US20090176864A1 (en) * 2004-11-24 2009-07-09 Hill's Pet Nutrition, Inc. Methods For Improving Hepatic and Immune Function In An Animal
US8252742B2 (en) 2004-12-30 2012-08-28 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
CA2592844C (en) 2004-12-30 2012-10-09 Hill's Pet Nutrition, Inc. Methods for enhancing the quality of life of a senior animal
BRPI0916476A2 (pt) * 2008-12-01 2016-02-16 Invasc Therapeutics Inc composição, método de tratamento para um distúrbio relacionado ao sistema renina-angiotensina-aldosterona, método para reduzir a resistência à insulina, método para tratar um distúrbio relacionado à síndrome metabólica
CN108484570B (zh) * 2018-05-15 2021-05-04 苏州富士莱医药股份有限公司 一种制备硫辛酸颗粒的方法及设备

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812590A3 (de) * 1989-11-09 1999-06-09 ASTA Medica Aktiengesellschaft Verwendung von R-Alpha-Liponsäure zur Zytoprotektion
DE4218572A1 (de) * 1992-06-05 1993-12-09 Asta Medica Ag Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E
DE4235912C2 (de) * 1992-10-23 2002-12-05 Viatris Gmbh Verfahren zur Herstellung kristalliner Thioctsäure und deren Verwendung
DE4433764A1 (de) * 1994-09-22 1996-03-28 Asta Medica Ag Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit

Also Published As

Publication number Publication date
CA2265276A1 (en) 1999-09-11
IN186598B (es) 2001-10-06
CY1106435T1 (el) 2011-04-06
EP0949258A1 (de) 1999-10-13
DE19810336A1 (de) 1999-09-23
DE59900364D1 (de) 2001-12-06
PT949258E (pt) 2002-04-29
DK0949258T3 (da) 2002-01-28
EP0949258B1 (de) 2001-10-31
US5994393A (en) 1999-11-30
ATE207914T1 (de) 2001-11-15
CA2265276C (en) 2009-09-08

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