ES2164018B1 - USE OF A LITHIUM SALT IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF THE INFECTION CAUSED BY THE HUMAN SYNTHETIC RESPIRATORY VIRUS (VRDH) - Google Patents
USE OF A LITHIUM SALT IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF THE INFECTION CAUSED BY THE HUMAN SYNTHETIC RESPIRATORY VIRUS (VRDH)Info
- Publication number
- ES2164018B1 ES2164018B1 ES200001347A ES200001347A ES2164018B1 ES 2164018 B1 ES2164018 B1 ES 2164018B1 ES 200001347 A ES200001347 A ES 200001347A ES 200001347 A ES200001347 A ES 200001347A ES 2164018 B1 ES2164018 B1 ES 2164018B1
- Authority
- ES
- Spain
- Prior art keywords
- treatment
- infection caused
- preparation
- protein
- lithium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Empleo de una sal de litio en la elaboración de un medicamento para el tratamiento de la infección causada por el virus respiratorio sincitial humano (VRSH). Sales de litio, de fórmula general ALi(n), donde A es el anión de la sal, Li es el catión litio, y n es un número entero igual al número de cargas negativas del anión, tienen la capacidad de inhibir o reducir la fosforilación del dominio III de fosforilación de la proteína P de VRSH, que parece ser esencial para la tetramerización de dicha proteína, localizado en el resto de serina situado en la posición 54 de dicha proteína P de VRSH y controlado por la fosfatasa PP2A, al inhibir específicamente a la proteína quinasa GSK-3. Dichas sales de litio son adecuadas para elaborar un medicamento para el tratamiento de la infección causada por VRSH.Use of a lithium salt in the preparation of a medicine for the treatment of infection caused by the human respiratory syncytial virus (RSVH). Lithium salts, of general formula ALi (n), where A is the salt anion, Li is the lithium cation, and n is an integer equal to the number of negative charges of the anion, they have the ability to inhibit or reduce phosphorylation of the III domain of phosphorylation of the VRSH P protein, which appears to be essential for the tetramerization of said protein, located in the serine moiety located at position 54 of said VRSH P protein and controlled by the PP2A phosphatase, by specifically inhibiting to protein kinase GSK-3. Said lithium salts are suitable for making a medicament for the treatment of infection caused by RSV.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001347A ES2164018B1 (en) | 2000-05-26 | 2000-05-26 | USE OF A LITHIUM SALT IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF THE INFECTION CAUSED BY THE HUMAN SYNTHETIC RESPIRATORY VIRUS (VRDH) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200001347A ES2164018B1 (en) | 2000-05-26 | 2000-05-26 | USE OF A LITHIUM SALT IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF THE INFECTION CAUSED BY THE HUMAN SYNTHETIC RESPIRATORY VIRUS (VRDH) |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2164018A1 ES2164018A1 (en) | 2002-02-01 |
ES2164018B1 true ES2164018B1 (en) | 2003-06-16 |
Family
ID=8493689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200001347A Expired - Fee Related ES2164018B1 (en) | 2000-05-26 | 2000-05-26 | USE OF A LITHIUM SALT IN THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF THE INFECTION CAUSED BY THE HUMAN SYNTHETIC RESPIRATORY VIRUS (VRDH) |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2164018B1 (en) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8320203D0 (en) * | 1983-07-27 | 1983-09-01 | Horrobin D F | Anti-viral compositions |
FR2620620B1 (en) * | 1987-09-22 | 1991-04-05 | Atlantic Pharma Prod | INHIBITOR OR DESTRUCTIVE SUBSTANCE OF AT LEAST ONE SINGLE-CELL LIVING BEING CONTAINING FLUORINE F- AND LITHIUM LI + |
ES2008767A6 (en) * | 1987-11-13 | 1989-08-01 | Medical Research Int | Destruction of intra-and extra-cellular micro-organisms |
GB9023701D0 (en) * | 1990-10-31 | 1990-12-12 | Efamol Holdings | Medical treatment |
FR2715301A1 (en) * | 1994-01-24 | 1995-07-28 | Aromafarm Ltd | Antiviral use of zinc and lithium ascorbate(s) |
GB9621990D0 (en) * | 1996-10-22 | 1996-12-18 | Scotia Pharma Ltd | Use |
CZ295765B6 (en) * | 1998-07-29 | 2005-10-12 | Apa - Praha, S.R.O. | Therapeutical preparation exhibiting virucidal activity |
-
2000
- 2000-05-26 ES ES200001347A patent/ES2164018B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2164018A1 (en) | 2002-02-01 |
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