ES2159479A1 - Nuevos indazoles como inhibidores de la ciclooxigenasa-ii - Google Patents
Nuevos indazoles como inhibidores de la ciclooxigenasa-iiInfo
- Publication number
- ES2159479A1 ES2159479A1 ES9902340A ES9902340A ES2159479A1 ES 2159479 A1 ES2159479 A1 ES 2159479A1 ES 9902340 A ES9902340 A ES 9902340A ES 9902340 A ES9902340 A ES 9902340A ES 2159479 A1 ES2159479 A1 ES 2159479A1
- Authority
- ES
- Spain
- Prior art keywords
- inhibitors
- indazols
- cyclooxygenase
- alzheimer
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nuevos indazoles como inhibidores de la ciclooxigenasa-II. La presente invención se refiere a compuestos de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo A es un enlace sencillo, -O-, -S- ó -NH-; R{sup,3} es hidrógeno, (C{sub,1}- C{sub,12})-alquilo, (C{sub,2} C{sub,12})-alquenilo, (C{sub,2}-C{sub,12})-alquinilo, (C{sub,1}- C{sub,12})-haloalquilo, (C{sub,1}-C{sub,12})-alquilcarbonilo, etc, a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9902340A ES2159479B1 (es) | 1999-10-25 | 1999-10-25 | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9902340A ES2159479B1 (es) | 1999-10-25 | 1999-10-25 | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2159479A1 true ES2159479A1 (es) | 2001-10-01 |
ES2159479B1 ES2159479B1 (es) | 2002-05-01 |
Family
ID=8310357
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9902340A Expired - Fee Related ES2159479B1 (es) | 1999-10-25 | 1999-10-25 | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2159479B1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008053031A1 (en) | 2006-11-03 | 2008-05-08 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387602A (en) * | 1993-08-30 | 1995-02-07 | Ortho Pharmaceutical Corporation | 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles |
WO1996038442A1 (en) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
WO1998022442A2 (en) * | 1996-11-15 | 1998-05-28 | Angelini Ricerche S.P.A. Societa' Consortile | Pharmaceutical compositions comprising diaryl-cyclomethylenpyrazole compounds and their use as cyclooxygenase i (cox 1) inhibitors |
EP0922697A1 (en) * | 1993-11-30 | 1999-06-16 | G.D. Searle & Co. | Substituted Pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors |
US6083969A (en) * | 1999-10-20 | 2000-07-04 | Ortho-Mcneil Pharaceutical, Inc. | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents |
-
1999
- 1999-10-25 ES ES9902340A patent/ES2159479B1/es not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5387602A (en) * | 1993-08-30 | 1995-02-07 | Ortho Pharmaceutical Corporation | 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles |
EP0922697A1 (en) * | 1993-11-30 | 1999-06-16 | G.D. Searle & Co. | Substituted Pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors |
EP0924201A1 (en) * | 1993-11-30 | 1999-06-23 | G.D. Searle & Co. | Tricyclic-substituted pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors |
WO1996038442A1 (en) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
WO1998022442A2 (en) * | 1996-11-15 | 1998-05-28 | Angelini Ricerche S.P.A. Societa' Consortile | Pharmaceutical compositions comprising diaryl-cyclomethylenpyrazole compounds and their use as cyclooxygenase i (cox 1) inhibitors |
US6083969A (en) * | 1999-10-20 | 2000-07-04 | Ortho-Mcneil Pharaceutical, Inc. | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents |
Non-Patent Citations (1)
Title |
---|
ANIL PRAKASH y col. HETEROCYCLIC COMPOUNDS-SULPHAMIDOBENZENEAZO-2,4-DINITROPHENYLACETONES AND THEIR CYCLISATION. J. Inst. Chemists (India). Julio 1973, Vol. 45, Pt 4, paginas 123-124. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008053031A1 (en) | 2006-11-03 | 2008-05-08 | Glaxo Group Limited | Compounds which potentiate ampa receptor and uses thereof in medicine |
Also Published As
Publication number | Publication date |
---|---|
ES2159479B1 (es) | 2002-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010120 Kind code of ref document: A1 Effective date: 20010120 |
|
FD1A | Patent lapsed |
Effective date: 20100312 |