ES2159479A1 - Nuevos indazoles como inhibidores de la ciclooxigenasa-ii - Google Patents

Nuevos indazoles como inhibidores de la ciclooxigenasa-ii

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Publication number
ES2159479A1
ES2159479A1 ES9902340A ES9902340A ES2159479A1 ES 2159479 A1 ES2159479 A1 ES 2159479A1 ES 9902340 A ES9902340 A ES 9902340A ES 9902340 A ES9902340 A ES 9902340A ES 2159479 A1 ES2159479 A1 ES 2159479A1
Authority
ES
Spain
Prior art keywords
inhibitors
indazols
cyclooxygenase
alzheimer
inflammation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9902340A
Other languages
English (en)
Other versions
ES2159479B1 (es
Inventor
Casellas David Mauleon
Perez M Luisa Garcia
Benet Albert Palomer
Avellana Jaime Pascual
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9902340A priority Critical patent/ES2159479B1/es
Publication of ES2159479A1 publication Critical patent/ES2159479A1/es
Application granted granted Critical
Publication of ES2159479B1 publication Critical patent/ES2159479B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Nuevos indazoles como inhibidores de la ciclooxigenasa-II. La presente invención se refiere a compuestos de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II, en los que el grupo A es un enlace sencillo, -O-, -S- ó -NH-; R{sup,3} es hidrógeno, (C{sub,1}- C{sub,12})-alquilo, (C{sub,2} C{sub,12})-alquenilo, (C{sub,2}-C{sub,12})-alquinilo, (C{sub,1}- C{sub,12})-haloalquilo, (C{sub,1}-C{sub,12})-alquilcarbonilo, etc, a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.
ES9902340A 1999-10-25 1999-10-25 Nuevos indazoles como inhibidores de la ciclooxigenasa-ii Expired - Fee Related ES2159479B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9902340A ES2159479B1 (es) 1999-10-25 1999-10-25 Nuevos indazoles como inhibidores de la ciclooxigenasa-ii

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9902340A ES2159479B1 (es) 1999-10-25 1999-10-25 Nuevos indazoles como inhibidores de la ciclooxigenasa-ii

Publications (2)

Publication Number Publication Date
ES2159479A1 true ES2159479A1 (es) 2001-10-01
ES2159479B1 ES2159479B1 (es) 2002-05-01

Family

ID=8310357

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9902340A Expired - Fee Related ES2159479B1 (es) 1999-10-25 1999-10-25 Nuevos indazoles como inhibidores de la ciclooxigenasa-ii

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ES (1) ES2159479B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008053031A1 (en) 2006-11-03 2008-05-08 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387602A (en) * 1993-08-30 1995-02-07 Ortho Pharmaceutical Corporation 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
WO1996038442A1 (en) * 1995-06-02 1996-12-05 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1998022442A2 (en) * 1996-11-15 1998-05-28 Angelini Ricerche S.P.A. Societa' Consortile Pharmaceutical compositions comprising diaryl-cyclomethylenpyrazole compounds and their use as cyclooxygenase i (cox 1) inhibitors
EP0922697A1 (en) * 1993-11-30 1999-06-16 G.D. Searle & Co. Substituted Pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors
US6083969A (en) * 1999-10-20 2000-07-04 Ortho-Mcneil Pharaceutical, Inc. 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387602A (en) * 1993-08-30 1995-02-07 Ortho Pharmaceutical Corporation 1.5-diphenyl-3-(N-hydroxycarbamoyloxyalkyl)pyrazoles
EP0922697A1 (en) * 1993-11-30 1999-06-16 G.D. Searle & Co. Substituted Pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors
EP0924201A1 (en) * 1993-11-30 1999-06-23 G.D. Searle & Co. Tricyclic-substituted pyrazolyl benzenesulfonamides and their use as cyclooxygenase II inhibitors
WO1996038442A1 (en) * 1995-06-02 1996-12-05 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1998022442A2 (en) * 1996-11-15 1998-05-28 Angelini Ricerche S.P.A. Societa' Consortile Pharmaceutical compositions comprising diaryl-cyclomethylenpyrazole compounds and their use as cyclooxygenase i (cox 1) inhibitors
US6083969A (en) * 1999-10-20 2000-07-04 Ortho-Mcneil Pharaceutical, Inc. 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANIL PRAKASH y col. HETEROCYCLIC COMPOUNDS-SULPHAMIDOBENZENEAZO-2,4-DINITROPHENYLACETONES AND THEIR CYCLISATION. J. Inst. Chemists (India). Julio 1973, Vol. 45, Pt 4, paginas 123-124. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008053031A1 (en) 2006-11-03 2008-05-08 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine

Also Published As

Publication number Publication date
ES2159479B1 (es) 2002-05-01

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