ES2158124T3 - Compuestos neurotroficos y antiproliferativos. - Google Patents
Compuestos neurotroficos y antiproliferativos.Info
- Publication number
- ES2158124T3 ES2158124T3 ES95930946T ES95930946T ES2158124T3 ES 2158124 T3 ES2158124 T3 ES 2158124T3 ES 95930946 T ES95930946 T ES 95930946T ES 95930946 T ES95930946 T ES 95930946T ES 2158124 T3 ES2158124 T3 ES 2158124T3
- Authority
- ES
- Spain
- Prior art keywords
- neurotrophic
- antiproliferative compounds
- compounds
- antiproliferative
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/18—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon triple bonds as unsaturation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/126—Acids containing more than four carbon atoms
- C07C53/128—Acids containing more than four carbon atoms the carboxylic group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/03—Monocarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Farming Of Fish And Shellfish (AREA)
Abstract
COMPUESTOS NEUROTROFICOS Y ANTIPROLIFERATIVOS RELACIONADOS CON VALPROATO DE FARMACO ANTIEPILEPTICO DE FORMULA GENERAL (I), EN DONDE R{SUP,1} ES -C=CH, -CH=CH{SUB,2} O -CH{SUB,2}-CH{SUB,3}, R{SUP,2} ES UN GRUPO ALQUILO C{SUB,1}-C{SUB,30} RAMIFICADO O NO RAMIFICADO, SATURADO, INSATURADO QUE ESTA OPCIONALMENTE SUSTITUIDO CON UN GRUPO HETEROCICLICO O DE CICLOHIDROCARBURO AROMATICO O ALIFATICO C{SUB,3}-C{SUB,9}. M ES UN HIDROGENO O UN ATOMO DE METAL. LA FORMULA (I) NO ES ACIDO 2-N-PROPIL-4PENTINOICO (4-YN-VPA) NI ACIDO 2-N-PROPIL-4-PENTENOICO (4-EN-VPA) Y CUANDO R{SUP,1} ES -CH{SUB,2}-CH{SUB,3}, R{SUP,2} ES C{SUB,5} A C{SUB,30}. ESTA INVENCION TAMBIEN PROPORCIONA UN METODO DE FABRICACION DE LOS COMPUESTOS DE LA INVENCION. LOS COMPUESTOS SON UTILES PARA PROMOVER LA FUNCION NEURONAL ASI COMO EN TRASTORNOS NEURODEGENERATIVOS Y PARA TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/298,108 US5672746A (en) | 1994-08-30 | 1994-08-30 | Antiproliferative and neurotrophic molecules |
US08/446,481 US6300373B1 (en) | 1993-09-10 | 1995-05-22 | Antiproliferative and neurotrophic molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2158124T3 true ES2158124T3 (es) | 2001-09-01 |
Family
ID=26970481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95930946T Expired - Lifetime ES2158124T3 (es) | 1994-08-30 | 1995-08-25 | Compuestos neurotroficos y antiproliferativos. |
Country Status (14)
Country | Link |
---|---|
US (3) | US6300373B1 (es) |
EP (1) | EP0778820B1 (es) |
JP (2) | JP3914568B2 (es) |
AT (1) | ATE200890T1 (es) |
AU (1) | AU3415195A (es) |
CA (1) | CA2198728A1 (es) |
DE (1) | DE69520832T2 (es) |
DK (1) | DK0778820T3 (es) |
ES (1) | ES2158124T3 (es) |
GR (1) | GR3036294T3 (es) |
HK (1) | HK1008882A1 (es) |
NZ (2) | NZ334119A (es) |
PT (1) | PT778820E (es) |
WO (1) | WO1996006821A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
EP1170008A1 (en) * | 2000-07-07 | 2002-01-09 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Valproic acid and derivatives thereof as histone deacetylase inhibitors |
EP1293205A1 (en) * | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
WO2003048301A2 (en) * | 2001-10-11 | 2003-06-12 | Protein Design Labs Inc. | Anti-hla-dr antibodies and the methods of using thereof |
AU2003289782A1 (en) * | 2002-12-16 | 2004-07-09 | The University Of British Columbia | Valproic acid analogues and pharmaceutical compositions thereof |
WO2007075077A1 (es) * | 2005-11-16 | 2007-07-05 | Universidad Nacional Autonoma De Mexico | Uso de agentes modificantes del transcriptoma más quimioterapia o radioterapia contra el cáncer |
BRPI0717972A2 (pt) * | 2006-11-01 | 2013-11-12 | Pronova Biopharma Norge As | Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar) |
ES2342997B1 (es) * | 2008-12-09 | 2011-06-06 | Universitat De Les Illes Balears | Alpha derivados de acidos grasos cis-monoinsaturados para ser usados como medicamento. |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1066578B (de) | 1959-10-08 | Dr. rer. nat. Karl Ernst Schulte, Berlin - Dahlem | Verfahren zur Herstellung von ungesättigten Lactonen | |
FR2442M (fr) | 1962-10-17 | 1964-04-06 | Henry Eugene | L'acide dipropylacétique et ses dérivés en tant que nouveuax médicaments dépresseurs du systeme nerveux central. |
GB1051322A (es) * | 1967-08-09 | |||
US3701729A (en) | 1970-06-01 | 1972-10-31 | Tenneco Chem | Oil-soluble mixed copper soap products |
US3847956A (en) | 1973-04-06 | 1974-11-12 | Us Agriculture | 2-hydroperoxycarboxylic acids and their preparation |
US3932285A (en) | 1973-10-03 | 1976-01-13 | Tenneco Chemicals, Inc. | Chromium salt compositions and a process for their production |
US4025649A (en) | 1974-08-19 | 1977-05-24 | Labaz | Acetic acid derivatives having pharmacological activity and compositions containing the same |
US4129599A (en) | 1975-04-28 | 1978-12-12 | The Board Of Trustees Of Leland Stanford Jr. University | A-Norsteroids |
JPS5650116A (en) | 1979-09-27 | 1981-05-07 | Tohoku Electric Power Co Inc | Manufacture of calcined gypsum |
JPS5680116A (en) | 1979-12-05 | 1981-07-01 | Sanyo Electric Co Ltd | Manufacture of substrate for magnetic bubble |
JPH0233704B2 (ja) | 1982-10-07 | 1990-07-30 | Takeda Chemical Industries Ltd | Chikanbinirukarubonsanjudotai |
FR2599737B1 (fr) | 1986-06-10 | 1989-05-19 | Sanofi Sa | Procede pour la fixation de groupes alkyles, alkenyles, cycloalkyles ou aralkyles sur une chaine carbonee portant un groupement fonctionnel |
JPH01135740A (ja) | 1987-11-24 | 1989-05-29 | Nippon Mining Co Ltd | 光学活性を有する2―アルキル―1―アルカン酸の製造方法 |
US5021398A (en) | 1989-10-26 | 1991-06-04 | Amp Incorporated | Method of forming patterned oxide superconducting films |
DE4231085A1 (de) * | 1992-09-12 | 1994-03-17 | Desitin Arzneimittel Gmbh | VPA-analoge Antiepileptika |
AU5678194A (en) | 1992-11-30 | 1994-06-22 | Procter & Gamble Company, The | High sudsing detergent compositions with specially selected soaps |
JP3304459B2 (ja) | 1992-12-18 | 2002-07-22 | 松下電器産業株式会社 | 電解コンデンサ駆動用電解液およびそれを用いた電解コンデンサ |
ATE163006T1 (de) | 1993-06-01 | 1998-02-15 | Ono Pharmaceutical Co | Pentansäurederivate |
US6300373B1 (en) * | 1993-09-10 | 2001-10-09 | American Biogenetic Sciences, Inc. | Antiproliferative and neurotrophic molecules |
WO1995033044A1 (en) | 1994-05-27 | 1995-12-07 | The Procter & Gamble Company | Liquid laundry detergent compositions comprising specially selected soaps |
-
1995
- 1995-05-22 US US08/446,481 patent/US6300373B1/en not_active Expired - Fee Related
- 1995-08-25 EP EP95930946A patent/EP0778820B1/en not_active Expired - Lifetime
- 1995-08-25 AU AU34151/95A patent/AU3415195A/en not_active Abandoned
- 1995-08-25 DE DE69520832T patent/DE69520832T2/de not_active Expired - Fee Related
- 1995-08-25 JP JP50885596A patent/JP3914568B2/ja not_active Expired - Fee Related
- 1995-08-25 AT AT95930946T patent/ATE200890T1/de not_active IP Right Cessation
- 1995-08-25 WO PCT/US1995/010775 patent/WO1996006821A1/en active IP Right Grant
- 1995-08-25 PT PT95930946T patent/PT778820E/pt unknown
- 1995-08-25 ES ES95930946T patent/ES2158124T3/es not_active Expired - Lifetime
- 1995-08-25 NZ NZ334119A patent/NZ334119A/xx unknown
- 1995-08-25 DK DK95930946T patent/DK0778820T3/da active
- 1995-08-25 CA CA002198728A patent/CA2198728A1/en not_active Abandoned
- 1995-08-25 NZ NZ292388A patent/NZ292388A/xx unknown
-
1998
- 1998-05-11 US US09/075,887 patent/US6274624B1/en not_active Expired - Fee Related
- 1998-08-01 HK HK98109610A patent/HK1008882A1/xx not_active IP Right Cessation
-
2001
- 2001-07-27 GR GR20010401144T patent/GR3036294T3/el not_active IP Right Cessation
- 2001-08-14 US US09/929,810 patent/US20020013367A1/en not_active Abandoned
-
2006
- 2006-10-24 JP JP2006288606A patent/JP2007091748A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69520832T2 (de) | 2001-08-09 |
CA2198728A1 (en) | 1996-03-07 |
DE69520832D1 (de) | 2001-06-07 |
EP0778820B1 (en) | 2001-05-02 |
US20020013367A1 (en) | 2002-01-31 |
EP0778820A1 (en) | 1997-06-18 |
MX9701594A (es) | 1998-07-31 |
NZ334119A (en) | 2000-09-29 |
JP2007091748A (ja) | 2007-04-12 |
AU3415195A (en) | 1996-03-22 |
US6274624B1 (en) | 2001-08-14 |
HK1008882A1 (en) | 1999-05-21 |
ATE200890T1 (de) | 2001-05-15 |
US6300373B1 (en) | 2001-10-09 |
JP3914568B2 (ja) | 2007-05-16 |
WO1996006821A1 (en) | 1996-03-07 |
JPH10505064A (ja) | 1998-05-19 |
NZ292388A (en) | 1999-03-29 |
GR3036294T3 (en) | 2001-10-31 |
PT778820E (pt) | 2001-10-31 |
DK0778820T3 (da) | 2001-08-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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