ES2155752A1 - Insulin analogue-protamine complex formulations - contg. an insulin analogue, protamine, zinc and a phenolic deriv., used for treating diabetes mellitus - Google Patents
Insulin analogue-protamine complex formulations - contg. an insulin analogue, protamine, zinc and a phenolic deriv., used for treating diabetes mellitusInfo
- Publication number
- ES2155752A1 ES2155752A1 ES9802174A ES9802174A ES2155752A1 ES 2155752 A1 ES2155752 A1 ES 2155752A1 ES 9802174 A ES9802174 A ES 9802174A ES 9802174 A ES9802174 A ES 9802174A ES 2155752 A1 ES2155752 A1 ES 2155752A1
- Authority
- ES
- Spain
- Prior art keywords
- protamine
- insulin analogue
- insulin
- zinc
- phenolic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Monomeric insulin analogue formulations.The present invention describes various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analogue, zinc, protamine, and a phenolic derivative. The analogue formulations provide a prolonged duration of action. A process for preparing insulin-protamine analogue formulations is also described.Insulin analogue-protamine complex (A) comprises:(a) human insulin where Pro at position B28 is substd. with Asp. Lys, Leu, Val or Ala, and Lys at position B29 is Lys or Pro, des(B28-B30)-human insulin or des(B27)-human insulin(b) protamine(c) zinc, and(d) a phenolic deriv. provided that when the insulin is AspB28-human insulin the concn. of protamine is 10 wt.%.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/260,633 US5461031A (en) | 1994-06-16 | 1994-06-16 | Monomeric insulin analog formulations |
ES09501196A ES2091728B1 (en) | 1994-06-16 | 1995-06-14 | MONOMERIC INSULIN ANALOG FORMULATIONS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2155752A1 true ES2155752A1 (en) | 2001-05-16 |
ES2155752B1 ES2155752B1 (en) | 2002-02-01 |
Family
ID=26154895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9802174A Expired - Fee Related ES2155752B1 (en) | 1994-06-16 | 1995-06-14 | FORMULATIONS OF MONOMERIC INSULIN ANALOGS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2155752B1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3868358A (en) * | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
-
1995
- 1995-06-14 ES ES9802174A patent/ES2155752B1/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3868358A (en) * | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
Non-Patent Citations (3)
Title |
---|
BRANGE, J. et al. "Chemical stability of insulin". ACTA. PHARM. NORD. 1992. Vol. 4, no 3, paginas 149-158. Todo el documento. * |
BREMS, D.N. et al. "Altering the association properties of insulin by amino acid replacement". PROTEIN ENGINEERING. 1992. Vol. 5, no 6, paginas 527-533. Todo el documento. * |
DEREWENDA, U. et al. "Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer". NATURE. 1989. Vol. 338, paginas 594-596. Todo el documento. * |
Also Published As
Publication number | Publication date |
---|---|
ES2155752B1 (en) | 2002-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20010516 Kind code of ref document: A1 Effective date: 20010516 |
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FD2A | Announcement of lapse in spain |
Effective date: 20150925 |