ES2155752A1 - Insulin analogue-protamine complex formulations - contg. an insulin analogue, protamine, zinc and a phenolic deriv., used for treating diabetes mellitus - Google Patents

Insulin analogue-protamine complex formulations - contg. an insulin analogue, protamine, zinc and a phenolic deriv., used for treating diabetes mellitus

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Publication number
ES2155752A1
ES2155752A1 ES9802174A ES9802174A ES2155752A1 ES 2155752 A1 ES2155752 A1 ES 2155752A1 ES 9802174 A ES9802174 A ES 9802174A ES 9802174 A ES9802174 A ES 9802174A ES 2155752 A1 ES2155752 A1 ES 2155752A1
Authority
ES
Spain
Prior art keywords
protamine
insulin analogue
insulin
zinc
phenolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9802174A
Other languages
Spanish (es)
Other versions
ES2155752B1 (en
Inventor
Felippis Michael R De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/260,633 external-priority patent/US5461031A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES2155752A1 publication Critical patent/ES2155752A1/en
Application granted granted Critical
Publication of ES2155752B1 publication Critical patent/ES2155752B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Monomeric insulin analogue formulations.The present invention describes various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analogue, zinc, protamine, and a phenolic derivative. The analogue formulations provide a prolonged duration of action. A process for preparing insulin-protamine analogue formulations is also described.Insulin analogue-protamine complex (A) comprises:(a) human insulin where Pro at position B28 is substd. with Asp. Lys, Leu, Val or Ala, and Lys at position B29 is Lys or Pro, des(B28-B30)-human insulin or des(B27)-human insulin(b) protamine(c) zinc, and(d) a phenolic deriv. provided that when the insulin is AspB28-human insulin the concn. of protamine is 10 wt.%.
ES9802174A 1994-06-16 1995-06-14 FORMULATIONS OF MONOMERIC INSULIN ANALOGS. Expired - Fee Related ES2155752B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/260,633 US5461031A (en) 1994-06-16 1994-06-16 Monomeric insulin analog formulations
ES09501196A ES2091728B1 (en) 1994-06-16 1995-06-14 MONOMERIC INSULIN ANALOG FORMULATIONS.

Publications (2)

Publication Number Publication Date
ES2155752A1 true ES2155752A1 (en) 2001-05-16
ES2155752B1 ES2155752B1 (en) 2002-02-01

Family

ID=26154895

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9802174A Expired - Fee Related ES2155752B1 (en) 1994-06-16 1995-06-14 FORMULATIONS OF MONOMERIC INSULIN ANALOGS.

Country Status (1)

Country Link
ES (1) ES2155752B1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868358A (en) * 1971-04-30 1975-02-25 Lilly Co Eli Protamine-insulin product

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRANGE, J. et al. "Chemical stability of insulin". ACTA. PHARM. NORD. 1992. Vol. 4, no 3, paginas 149-158. Todo el documento. *
BREMS, D.N. et al. "Altering the association properties of insulin by amino acid replacement". PROTEIN ENGINEERING. 1992. Vol. 5, no 6, paginas 527-533. Todo el documento. *
DEREWENDA, U. et al. "Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer". NATURE. 1989. Vol. 338, paginas 594-596. Todo el documento. *

Also Published As

Publication number Publication date
ES2155752B1 (en) 2002-02-01

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