ES2154242B1 - NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB. - Google Patents

NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.

Info

Publication number
ES2154242B1
ES2154242B1 ES009902013A ES9902013A ES2154242B1 ES 2154242 B1 ES2154242 B1 ES 2154242B1 ES 009902013 A ES009902013 A ES 009902013A ES 9902013 A ES9902013 A ES 9902013A ES 2154242 B1 ES2154242 B1 ES 2154242B1
Authority
ES
Spain
Prior art keywords
htb
triflusal
biocompatible polymeric
polymeric systems
new biocompatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009902013A
Other languages
Spanish (es)
Other versions
ES2154242A1 (en
Inventor
Alberto Gallardo
Gema Rodriguez
Roman Julio San
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES009902013A priority Critical patent/ES2154242B1/en
Priority to ARP000104307A priority patent/AR033343A1/en
Priority to BR0013760-0A priority patent/BR0013760A/en
Priority to EP00956531A priority patent/EP1210954B1/en
Priority to DE60019766T priority patent/DE60019766T2/en
Priority to JP2001521365A priority patent/JP2003508592A/en
Priority to AU68436/00A priority patent/AU6843600A/en
Priority to ES00956531T priority patent/ES2241641T3/en
Priority to DK00956531T priority patent/DK1210954T3/en
Priority to MXPA02002288A priority patent/MXPA02002288A/en
Priority to KR1020027002856A priority patent/KR100838545B1/en
Priority to US10/070,244 priority patent/US6979465B1/en
Priority to CA002383780A priority patent/CA2383780A1/en
Priority to SI200030675T priority patent/SI1210954T1/xx
Priority to AT00956531T priority patent/ATE294001T1/en
Priority to PT00956531T priority patent/PT1210954E/en
Priority to TR2002/00591T priority patent/TR200200591T2/en
Priority to PCT/ES2000/000335 priority patent/WO2001017578A1/en
Publication of ES2154242A1 publication Critical patent/ES2154242A1/en
Application granted granted Critical
Publication of ES2154242B1 publication Critical patent/ES2154242B1/en
Priority to NO20021027A priority patent/NO20021027L/en
Priority to US11/267,209 priority patent/US7445789B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/302—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and two or more oxygen atoms in the alcohol moiety
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
    • C08F220/30—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety
    • C08F220/305—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety
    • C08F220/306—Esters containing oxygen in addition to the carboxy oxygen containing aromatic rings in the alcohol moiety and containing a polyether chain in the alcohol moiety and polyethylene oxide chain in the alcohol moiety

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Paints Or Removers (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen nuevos sistemas poliméricos biocompatibles portadores de tríflusal o HTB resultantes de la polimerización de un monómero A de tipo acrílico o vínilico portador de triflusal o HTB, en el que el triflusal o el HTB se hallan unidos al resto de la molécula de dicho monómero a través de un enlace covalente hidrolizable in vivo, y opcionalmente de un segundo monómero B polimerizable. Estos nuevos sistemas poliméricos son útiles como recubrimiento de biomateriales sintéticos.New biocompatible polymer systems carrying triflusal or HTB resulting from the polymerization of an acrylic or vinylic monomer type A carrying triflusal or HTB are described, in which the triflusal or HTB are bound to the rest of the molecule of said monomer a through an in vivo hydrolysable covalent bond, and optionally a second polymerizable B monomer. These new polymer systems are useful as a coating of synthetic biomaterials.

ES009902013A 1999-09-03 1999-09-03 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB. Expired - Fee Related ES2154242B1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ES009902013A ES2154242B1 (en) 1999-09-03 1999-09-03 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.
ARP000104307A AR033343A1 (en) 1999-09-03 2000-08-18 A BIOCOMPATIBLE TRIMLUSAL OR HTB POLYMERIC COMPOUND, PREPARATION PROCEDURE, USE OF THE COMPOUND AND ARTICLE THAT INCLUDES IT.
SI200030675T SI1210954T1 (en) 1999-09-03 2000-09-01
DE60019766T DE60019766T2 (en) 1999-09-03 2000-09-01 TRIFLUSAL OR HTB CARRYING BIOKOMPATIBLE POLYMER SYSTEMS
JP2001521365A JP2003508592A (en) 1999-09-03 2000-09-01 Novel biocompatible polymer system with triflusal or HTB
AU68436/00A AU6843600A (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or htb
ES00956531T ES2241641T3 (en) 1999-09-03 2000-09-01 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.
DK00956531T DK1210954T3 (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or HTB
MXPA02002288A MXPA02002288A (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or htb.
KR1020027002856A KR100838545B1 (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or htb
BR0013760-0A BR0013760A (en) 1999-09-03 2000-09-01 Biocompatible polymeric systems carrying triflusal or htb
CA002383780A CA2383780A1 (en) 1999-09-03 2000-09-01 New biocompatible polymeric systems carrying triflusal or htb
EP00956531A EP1210954B1 (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or htb
AT00956531T ATE294001T1 (en) 1999-09-03 2000-09-01 TRIFLUSAL OR HTB BEARING BIOCOMPATIBLE POLYMER SYSTEMS
PT00956531T PT1210954E (en) 1999-09-03 2000-09-01 NEW SYSTEMS OF BIOCOMPATIBLE POLYMERS CONTAINING TRIFLUSAL OR HTB
TR2002/00591T TR200200591T2 (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or HTB
PCT/ES2000/000335 WO2001017578A1 (en) 1999-09-03 2000-09-01 New biocompatible polymer systems carrying triflusal or htb
US10/070,244 US6979465B1 (en) 1999-09-03 2000-09-01 Biocompatible polymer systems carrying triflusal or HTB
NO20021027A NO20021027L (en) 1999-09-03 2002-03-01 Biocompatible polymer systems bearing trifusal or HTB
US11/267,209 US7445789B2 (en) 1999-09-03 2005-11-07 Biocompatible polymeric systems carrying triflusal or HTB

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902013A ES2154242B1 (en) 1999-09-03 1999-09-03 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.

Publications (2)

Publication Number Publication Date
ES2154242A1 ES2154242A1 (en) 2001-03-16
ES2154242B1 true ES2154242B1 (en) 2001-10-16

Family

ID=8309883

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009902013A Expired - Fee Related ES2154242B1 (en) 1999-09-03 1999-09-03 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.
ES00956531T Expired - Lifetime ES2241641T3 (en) 1999-09-03 2000-09-01 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES00956531T Expired - Lifetime ES2241641T3 (en) 1999-09-03 2000-09-01 NEW BIOCOMPATIBLE POLYMERIC SYSTEMS CARRIERS OF TRIFLUSAL OR HTB.

Country Status (17)

Country Link
US (2) US6979465B1 (en)
EP (1) EP1210954B1 (en)
JP (1) JP2003508592A (en)
KR (1) KR100838545B1 (en)
AR (1) AR033343A1 (en)
AT (1) ATE294001T1 (en)
AU (1) AU6843600A (en)
BR (1) BR0013760A (en)
CA (1) CA2383780A1 (en)
DE (1) DE60019766T2 (en)
DK (1) DK1210954T3 (en)
ES (2) ES2154242B1 (en)
MX (1) MXPA02002288A (en)
NO (1) NO20021027L (en)
PT (1) PT1210954E (en)
TR (1) TR200200591T2 (en)
WO (1) WO2001017578A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1767552A1 (en) * 2005-09-21 2007-03-28 Palau Pharma, S.A. Triflusal-containing polymers for stent coating

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096252A (en) * 1976-06-10 1978-06-20 J. Uriach & Cia S.A. 4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
GB2167665A (en) * 1984-12-04 1986-06-04 Univ Liverpool Platelet aggregation inhibitor for use in polymeric surgical devices
JPH0221875A (en) * 1988-07-11 1990-01-24 Terumo Corp Medical material and medical appliance
EP0351314B1 (en) * 1988-07-11 1995-02-01 Terumo Kabushiki Kaisha Medical material and medical implement
US5344455A (en) * 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
GB9608882D0 (en) * 1996-04-30 1996-07-03 Luthra Ajay K Non-thrombogenic and anti-thrombogenic polymers
ES2136581B1 (en) * 1998-05-27 2000-09-16 Uriach & Cia Sa J USE OF DERIVATIVES OF ACID-2-HIDROXI-4-TRIFLUOROMETILBENZOICO FOR THE PREPARATION OF USEFUL MEDICINES TO INHIBIT THE NUCLEAR TRANSCRIPTION FACTOR NF-KB.

Also Published As

Publication number Publication date
AR033343A1 (en) 2003-12-17
KR20020059387A (en) 2002-07-12
ES2154242A1 (en) 2001-03-16
JP2003508592A (en) 2003-03-04
ATE294001T1 (en) 2005-05-15
MXPA02002288A (en) 2002-07-30
ES2241641T3 (en) 2005-11-01
BR0013760A (en) 2002-07-02
US20060067955A1 (en) 2006-03-30
US7445789B2 (en) 2008-11-04
US6979465B1 (en) 2005-12-27
KR100838545B1 (en) 2008-06-17
DE60019766D1 (en) 2005-06-02
WO2001017578A1 (en) 2001-03-15
EP1210954A1 (en) 2002-06-05
EP1210954B1 (en) 2005-04-27
PT1210954E (en) 2005-07-29
CA2383780A1 (en) 2001-03-15
NO20021027D0 (en) 2002-03-01
TR200200591T2 (en) 2002-06-21
DE60019766T2 (en) 2006-01-19
DK1210954T3 (en) 2005-08-15
AU6843600A (en) 2001-04-10
NO20021027L (en) 2002-04-10

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