ES2151459A1 - Human genetic sequences which are homologous to the yeast genes involved in the proteolytic processing of prenylated proteins - Google Patents
Human genetic sequences which are homologous to the yeast genes involved in the proteolytic processing of prenylated proteinsInfo
- Publication number
- ES2151459A1 ES2151459A1 ES009901608A ES9901608A ES2151459A1 ES 2151459 A1 ES2151459 A1 ES 2151459A1 ES 009901608 A ES009901608 A ES 009901608A ES 9901608 A ES9901608 A ES 9901608A ES 2151459 A1 ES2151459 A1 ES 2151459A1
- Authority
- ES
- Spain
- Prior art keywords
- homologous
- proteolytic processing
- human genetic
- genetic sequences
- genes involved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Human genetic sequences which are homologous to the yeast gene involved in the proteolytic processing of prenylated proteins. The invention comprises the identification of homologous fragments of human genes AFC1 and RCE1 of Saccharomyces cerevisiae, amplifying them through PCR of total RNA, using the amplified fragments as probes to hybridize cDNA and determining the sequence of the clones of cDNA which hybridize with the probes. The identified sequences are SEQ ID NO: 1 and SEQ ID NO: 2. The applications of said sequences concern essentially diagnosis and treatment of oncogenic troubles.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9800016A ES2149672B1 (en) | 1998-01-08 | 1998-01-08 | HUMAN GENE SEQUENCE APPROVES THE AFC1 GENE OF LEAVES INVOLVED IN THE PROTEOLITIC PROCESSING OF PRENILED PROTEINS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2151459A1 true ES2151459A1 (en) | 2000-12-16 |
ES2151459B1 ES2151459B1 (en) | 2001-07-01 |
Family
ID=8302331
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9800016A Expired - Fee Related ES2149672B1 (en) | 1998-01-08 | 1998-01-08 | HUMAN GENE SEQUENCE APPROVES THE AFC1 GENE OF LEAVES INVOLVED IN THE PROTEOLITIC PROCESSING OF PRENILED PROTEINS. |
ES9901608A Expired - Fee Related ES2151459B1 (en) | 1998-01-08 | 1998-01-08 | HUMAN GENE SEQUENCE APPROVES THE RCE1 GENE OF YEAST INVOLVED IN THE PROTEOLITIC PROCESSING OF PRENILED PROTEINS. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9800016A Expired - Fee Related ES2149672B1 (en) | 1998-01-08 | 1998-01-08 | HUMAN GENE SEQUENCE APPROVES THE AFC1 GENE OF LEAVES INVOLVED IN THE PROTEOLITIC PROCESSING OF PRENILED PROTEINS. |
Country Status (2)
Country | Link |
---|---|
ES (2) | ES2149672B1 (en) |
WO (1) | WO1999035275A1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002509428A (en) * | 1996-08-07 | 2002-03-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | AFC1 and RCE1: isoprenylated CAAX processing enzyme |
WO1998054333A2 (en) * | 1997-06-02 | 1998-12-03 | Acacia Biosciences Inc. | Mammalian caax processing enzymes |
CA2234418A1 (en) * | 1997-06-24 | 1998-12-24 | Smithkline Beecham Corporation | Human afc1 |
CA2234402A1 (en) * | 1997-06-24 | 1998-12-24 | Smithkline Beecham Corporation | Human rce1 |
-
1998
- 1998-01-08 ES ES9800016A patent/ES2149672B1/en not_active Expired - Fee Related
- 1998-01-08 ES ES9901608A patent/ES2151459B1/en not_active Expired - Fee Related
-
1999
- 1999-01-08 WO PCT/ES1999/000001 patent/WO1999035275A1/en active Application Filing
Non-Patent Citations (3)
Title |
---|
ASHBY, M.N. et al. "Ras and a-Factor converting enzyme", METHODS IN ENZYMOLOGY, 1995, Vol. 250, paginas 235-251. * |
BASSET, D.E. et al. "Genome cross-referencing and XREF db: Implications for the identification and analysis of genes mutated in human disease", NATURE GENETICS, 1997, Vol. 15, paginas 339-344. * |
BOYARTCHUK, V.L. et al. "Modulation of Ras and a-Factor function by carboxylterminal proteolysis", SCIENCE, 1997, Vol. 275, paginas 1760-1800. * |
Also Published As
Publication number | Publication date |
---|---|
ES2149672A1 (en) | 2000-11-01 |
ES2149672B1 (en) | 2001-05-16 |
WO1999035275A1 (en) | 1999-07-15 |
ES2151459B1 (en) | 2001-07-01 |
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Legal Events
Date | Code | Title | Description |
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EC2A | Search report published |
Date of ref document: 20001216 Kind code of ref document: A1 Effective date: 20001216 |
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FD2A | Announcement of lapse in spain |
Effective date: 20180426 |