ES2149687B1 - PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME. - Google Patents

PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME.

Info

Publication number
ES2149687B1
ES2149687B1 ES9800757A ES9800757A ES2149687B1 ES 2149687 B1 ES2149687 B1 ES 2149687B1 ES 9800757 A ES9800757 A ES 9800757A ES 9800757 A ES9800757 A ES 9800757A ES 2149687 B1 ES2149687 B1 ES 2149687B1
Authority
ES
Spain
Prior art keywords
obtaining
fluorophenyl
trans
procedure
hydroximethylpiperidins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9800757A
Other languages
Spanish (es)
Other versions
ES2149687A1 (en
Inventor
Diez Del Corral Alberto Stampa
Garcia Pelayo Camps
Llado Jordi Bosch
Lascorz Juan Contreras
Miguel M-Carmen Onrubia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES9800757A priority Critical patent/ES2149687B1/en
Publication of ES2149687A1 publication Critical patent/ES2149687A1/en
Application granted granted Critical
Publication of ES2149687B1 publication Critical patent/ES2149687B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Procedimiento de obtención de (+) -trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de síntesis para las mismas; los productos son de fórmula (I) (R es H o CH3 ) y el procedimiento se basa en la reducción de compuestos de fórmula (II) (R1 es H o CH3 y R2 un alquilo C1-C4 ). Estos productos de fórmula (I) son importantes intermedios para la obtención del antidepresivo paroxetina.Procedure for obtaining (+) -trans-4- (4-fluorophenyl) -3-hydroxymethylpiperidines and synthesis intermediates therefor; the products are of formula (I) (R is H or CH3) and the process is based on the reduction of compounds of formula (II) (R1 is H or CH3 and R2 a C1-C4 alkyl). These products of formula (I) are important intermediates for obtaining the antidepressant paroxetine.

ES9800757A 1998-04-08 1998-04-08 PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME. Expired - Fee Related ES2149687B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9800757A ES2149687B1 (en) 1998-04-08 1998-04-08 PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9800757A ES2149687B1 (en) 1998-04-08 1998-04-08 PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME.

Publications (2)

Publication Number Publication Date
ES2149687A1 ES2149687A1 (en) 2000-11-01
ES2149687B1 true ES2149687B1 (en) 2001-05-16

Family

ID=8303411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9800757A Expired - Fee Related ES2149687B1 (en) 1998-04-08 1998-04-08 PROCEDURE FOR OBTAINING (+ -) - TRANS-4- (4-FLUOROPHENYL) -3-HYDROXIMETHYLPIPERIDINS AND SYNTHESIS INTERMEDIATES FOR THE SAME.

Country Status (1)

Country Link
ES (1) ES2149687B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH636858A5 (en) * 1977-01-17 1983-06-30 Ciba Geigy Ag METHOD FOR PRODUCING NEW PHENYLAZACYCLOAL CHANES.
EP0190496A3 (en) * 1984-12-13 1987-05-27 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
JP3446468B2 (en) * 1996-04-15 2003-09-16 旭硝子株式会社 Method for producing piperidine carbinols

Also Published As

Publication number Publication date
ES2149687A1 (en) 2000-11-01

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