ES2146556A1 - Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos. - Google Patents

Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Info

Publication number
ES2146556A1
ES2146556A1 ES9901180A ES9901180A ES2146556A1 ES 2146556 A1 ES2146556 A1 ES 2146556A1 ES 9901180 A ES9901180 A ES 9901180A ES 9901180 A ES9901180 A ES 9901180A ES 2146556 A1 ES2146556 A1 ES 2146556A1
Authority
ES
Spain
Prior art keywords
hapalosphaeria
deformans
inhibitors
derivatives
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9901180A
Other languages
English (en)
Other versions
ES2146556B1 (es
Inventor
Monedero Emilio Diez
Steve W Elson
Los Frailes Alvarez Maite De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9800277A external-priority patent/ES2146532B1/es
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES9901180A priority Critical patent/ES2146556B1/es
Publication of ES2146556A1 publication Critical patent/ES2146556A1/es
Application granted granted Critical
Publication of ES2146556B1 publication Critical patent/ES2146556B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Derivados de hidrocarburos aromáticos carbocíclicos producidos por hapalosphaeria deformans, inhibidores de la interacción de CD28 y sus receptores específicos. La presente invención proporciona nuevos compuestos derivados de aromáticos carbocíclicos, que pueden obtenerse mediante el cultivo de microorganismos que pueden ser cepas de hongos, en particular Hapalosphaeria deformaras u otros taxonómicamente relacionados. Estas sustancias son inhibidores de glicoproteínas, y particularmente de CD28, pudiendo actuar mediante la disrupción de las interacciones de CD28 con su receptor específico. La presente invención también proporciona procedimientos para la producción de los nuevos compuestos y otros metabolitos inhibidores de la glicoproteína o derivados de los mismos, que comprenden el cultivo de los microorganismos productores apropiados y el aislamiento de los metabolitos o sus derivados a partir de los cultivos.
ES9901180A 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos. Expired - Fee Related ES2146556B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9901180A ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9800277A ES2146532B1 (es) 1998-02-12 1998-02-12 Compuestos organicos producidos por microorganismos, en particular exophiala pisciphila, y su uso como inhibidores de la interaccion de cd28 y sus receptores especificos
ES9901180A ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Publications (2)

Publication Number Publication Date
ES2146556A1 true ES2146556A1 (es) 2000-08-01
ES2146556B1 ES2146556B1 (es) 2001-02-01

Family

ID=26155127

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9901180A Expired - Fee Related ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Country Status (1)

Country Link
ES (1) ES2146556B1 (es)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHU, Y.Z. et al. "Haloemodins, a new class of endothelin-1 type B (ETB) receptor binding inhibitors". JOURNAL OF ANTIBIOTICS, Vol. 47, no 11, 1994, paginas 1328-32, pagina 1329, figura 2. *

Also Published As

Publication number Publication date
ES2146556B1 (es) 2001-02-01

Similar Documents

Publication Publication Date Title
WO2007136815A3 (en) Tagged microorganisms and methods of tagging
DE602005019419D1 (de) Ferulat esterase produzierende stämme und methoden zu deren nutzung
WO2012018624A3 (en) Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
ATE454463T1 (de) Überexpression von extremozymgenen in pseudomonas und nahe verwandte bakterien
WO2003012058A3 (en) Media and methods for cultivation of microorganisms
DE69721282T2 (de) In vitro transpositionsystem unter verwendung einer modifizierten tn5 transposase
MX2021009886A (es) Enzimas con dominios ruvc.
IL137093A0 (en) Methods of inactivating bacteria including bacterial spores
AU9536898A (en) 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the holesterin-ester transfer protein
WO2006108136A3 (en) Generation of materials with enhanced hydrogen content from anaerobic microbial consortia
WO2010034018A3 (en) Msp nanopores and related methods
WO2007044418A3 (en) Cell culture media, kits and methods of use
MX2022014067A (es) Enzimas con dominios ruvc.
WO2006132944A3 (en) Probiotic system for aquaculture
HK1056292A1 (en) Method of culturing zooplankton, apparatus for culturing by the same, and culture obtained by the same.
WO2005002497A3 (en) BIFUNCTIONAL ANTIBIOTICS FOR TARGETING rRNA AND RESISTANCE-CAUSING ENZYMES
NZ335519A (en) method of screening non-pathogenic bacteria capable of binding to tissue adhesion receptors
WO2005000876A3 (en) Ring finger family proteins and uses related thereto
ES2146556A1 (es) Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.
CL2009000674A1 (es) Cepa de myxococcus virescens st200611 (dsm 15898) y procedimiento para preparar compuestos derivados de bengamida mediante fermentacion con dichos microorganismos.
WO2004094316A3 (en) Bioremediation of petroleum pollution using water-insoluble uric acid as the nitrogen source
AR010744A1 (es) Inhibidores polipropilos de ciclofilina
AU2003236740A1 (en) Genetically modified microorganisms, plasmid and fermentation process with the presence of flocculation regulated by medium changes
GB0001567D0 (en) Culture medium for culturing lactobacillus clearans,and method for preserving said strain
MY132876A (en) Method for visually demonstrating the effectiveness of an anti-bacteria attachment composition

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20000801

Kind code of ref document: A1

Effective date: 20000801

FD2A Announcement of lapse in spain

Effective date: 20180807