ES2146556A1 - Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos. - Google Patents

Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

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Publication number
ES2146556A1
ES2146556A1 ES9901180A ES9901180A ES2146556A1 ES 2146556 A1 ES2146556 A1 ES 2146556A1 ES 9901180 A ES9901180 A ES 9901180A ES 9901180 A ES9901180 A ES 9901180A ES 2146556 A1 ES2146556 A1 ES 2146556A1
Authority
ES
Spain
Prior art keywords
hapalosphaeria
deformans
inhibitors
derivatives
interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9901180A
Other languages
English (en)
Other versions
ES2146556B1 (es
Inventor
Monedero Emilio Diez
Steve W Elson
Los Frailes Alvarez Maite De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham SA
Original Assignee
SmithKline Beecham SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9800277A external-priority patent/ES2146532B1/es
Application filed by SmithKline Beecham SA filed Critical SmithKline Beecham SA
Priority to ES9901180A priority Critical patent/ES2146556B1/es
Publication of ES2146556A1 publication Critical patent/ES2146556A1/es
Application granted granted Critical
Publication of ES2146556B1 publication Critical patent/ES2146556B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Derivados de hidrocarburos aromáticos carbocíclicos producidos por hapalosphaeria deformans, inhibidores de la interacción de CD28 y sus receptores específicos. La presente invención proporciona nuevos compuestos derivados de aromáticos carbocíclicos, que pueden obtenerse mediante el cultivo de microorganismos que pueden ser cepas de hongos, en particular Hapalosphaeria deformaras u otros taxonómicamente relacionados. Estas sustancias son inhibidores de glicoproteínas, y particularmente de CD28, pudiendo actuar mediante la disrupción de las interacciones de CD28 con su receptor específico. La presente invención también proporciona procedimientos para la producción de los nuevos compuestos y otros metabolitos inhibidores de la glicoproteína o derivados de los mismos, que comprenden el cultivo de los microorganismos productores apropiados y el aislamiento de los metabolitos o sus derivados a partir de los cultivos.
ES9901180A 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos. Expired - Fee Related ES2146556B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9901180A ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9800277A ES2146532B1 (es) 1998-02-12 1998-02-12 Compuestos organicos producidos por microorganismos, en particular exophiala pisciphila, y su uso como inhibidores de la interaccion de cd28 y sus receptores especificos
ES9901180A ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Publications (2)

Publication Number Publication Date
ES2146556A1 true ES2146556A1 (es) 2000-08-01
ES2146556B1 ES2146556B1 (es) 2001-02-01

Family

ID=26155127

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9901180A Expired - Fee Related ES2146556B1 (es) 1998-02-12 1999-05-31 Derivados de hidrocarburos aromaticos carbociclicos producidos por hapalosphaeria deformans, inhibidores de la interaccion de cd28 y sus re ceptores especificos.

Country Status (1)

Country Link
ES (1) ES2146556B1 (es)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHU, Y.Z. et al. "Haloemodins, a new class of endothelin-1 type B (ETB) receptor binding inhibitors". JOURNAL OF ANTIBIOTICS, Vol. 47, no 11, 1994, paginas 1328-32, pagina 1329, figura 2. *

Also Published As

Publication number Publication date
ES2146556B1 (es) 2001-02-01

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