ES2143403B1 - DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS. - Google Patents

DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS.

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Publication number
ES2143403B1
ES2143403B1 ES9800553A ES9800553A ES2143403B1 ES 2143403 B1 ES2143403 B1 ES 2143403B1 ES 9800553 A ES9800553 A ES 9800553A ES 9800553 A ES9800553 A ES 9800553A ES 2143403 B1 ES2143403 B1 ES 2143403B1
Authority
ES
Spain
Prior art keywords
sub
same
derivatives
substituents
branched chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9800553A
Other languages
Spanish (es)
Other versions
ES2143403A1 (en
Inventor
Diez Francisco Camps
Biosca Montserrat Cano
Domingo Gemma Fabrias
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9800553A priority Critical patent/ES2143403B1/en
Publication of ES2143403A1 publication Critical patent/ES2143403A1/en
Application granted granted Critical
Publication of ES2143403B1 publication Critical patent/ES2143403B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados de ciclopropenilaminas como agentes anticancerosos. Compuestos cuya fórmula general se representa en la figura 1, en los que R{sub,1 y R{sub,2 pueden tener el mismo o distinto valor, representan grupos alquilo o finilaquilo de cadena lineal o ramificada de 1 a unos 18 átomos de carbono que pueden contener una o varias instauraciones en la cadena y sustituyentes X en el extremo de dicha cadena donde X representa -OH, OR, donde R es un alquilo o metiloxialquilo de cadena lineal o ramificada de 1 a 5 átomos de carbono, COOH, CO{sub,2 R, donde R tiene el mismo valor anterior, CON(R){sub,2 , donde R puede tener el mismo valor anterior, y halógeno (F, Cl, Br, I) y donde los sustituyentes R{sub,3 y R{sub,4 pueden ser grupos alquilo alquenilo o arilo, de valores iguales o distintos, o pueden formar parte de un anillo aromático o del tipo ftalimida. Miembros de esta nueva clase de compuestos han mostrado una extraordinaria actividad citotóxica en inhibir in vitro el crecimiento celular demuy diversos tumores cancerosos.Cyclopropenylamin derivatives as anticancer agents. Compounds whose general formula is represented in Figure 1, in which R {sub, 1 and R {sub, 2 may have the same or different value, represent straight or branched chain alkyl or finylalkyl groups of 1 to about 18 atoms of carbon which may contain one or more installations in the chain and substituents X at the end of said chain where X represents -OH, OR, where R is a straight or branched chain alkyl or methyloxyalkyl of 1 to 5 carbon atoms, COOH, CO {sub, 2 R, where R has the same previous value, CON (R) {sub, 2, where R can have the same previous value, and halogen (F, Cl, Br, I) and where the substituents R { sub, 3 and R {sub, 4 may be alkenyl or aryl alkyl groups, of the same or different values, or may be part of an aromatic ring or of the phthalimide type. Members of this new class of compounds have shown extraordinary cytotoxic activity in inhibiting cell growth in vitro, and various cancerous tumors.

ES9800553A 1998-03-13 1998-03-13 DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS. Expired - Fee Related ES2143403B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9800553A ES2143403B1 (en) 1998-03-13 1998-03-13 DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9800553A ES2143403B1 (en) 1998-03-13 1998-03-13 DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS.

Publications (2)

Publication Number Publication Date
ES2143403A1 ES2143403A1 (en) 2000-05-01
ES2143403B1 true ES2143403B1 (en) 2001-01-01

Family

ID=8303120

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9800553A Expired - Fee Related ES2143403B1 (en) 1998-03-13 1998-03-13 DERIVATIVES OF CYCLOPROPENYLAMINS AS ANTI-TARGET AGENTS.

Country Status (1)

Country Link
ES (1) ES2143403B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431669A (en) * 1982-12-17 1984-02-14 Schering Corporation Cyclopropyl substituted polyenes
FR2751645B1 (en) * 1996-07-29 1998-12-24 Sanofi Sa AMINES FOR THE MANUFACTURE OF DRUGS TO PREVENT THE PROLIFERATION OF TUMOR CELLS

Also Published As

Publication number Publication date
ES2143403A1 (en) 2000-05-01

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