ES2138074T3 - Aerosol anestesico en base a lidocaina. - Google Patents

Aerosol anestesico en base a lidocaina.

Info

Publication number
ES2138074T3
ES2138074T3 ES94909882T ES94909882T ES2138074T3 ES 2138074 T3 ES2138074 T3 ES 2138074T3 ES 94909882 T ES94909882 T ES 94909882T ES 94909882 T ES94909882 T ES 94909882T ES 2138074 T3 ES2138074 T3 ES 2138074T3
Authority
ES
Spain
Prior art keywords
anaesthetic
lidocaine
airway
hfc
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909882T
Other languages
English (en)
Inventor
Richard A Henry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LYNCHRIS PHARM Ltd
Original Assignee
LYNCHRIS PHARM Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LYNCHRIS PHARM Ltd filed Critical LYNCHRIS PHARM Ltd
Application granted granted Critical
Publication of ES2138074T3 publication Critical patent/ES2138074T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Dispersion Chemistry (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

LA COMPOSICION DE LA PRESENTE INVENCION COMBINA LA LIDOCAINA ANESTESICA LOCAL A MODO DE BASE LIBRE Y HFC-134A (1,1,1,2TETRAFLUORETANO; CF{SUB,3}CH{SUB,2}F) O HFC-227 (1,1,1,2,3,3,3HEPTAFLUOPROPANO; CF{SUB,3}CHFCF{SUB,3}) PROPULSOR DE AEROSOL NO CFC O UNA COMBINACION DE LOS MISMOS, CON LO QUE INCORPORA CANTIDADES QUE HASTA AHORA NO SE PODIAN CONSEGUIR DE LA BASE LIBRE DE LIDOCAINA EN SOLUCION EN UN PROPULSOR DE AEROSOL NO CFC. ESTA FORMA PARTICULAR DE ANESTESICO SIN COSOLVENTES RELATIVAMENTE CONCENTRADO PERMITE UN SUMINISTRO MEJORADO DE LA INHALACION A LAS VIAS RESPIRATORIAS Y A LOS PULMONES, Y DE ESTE MODO SE CONSIGUE FACILMENTE UNA ANESTESIA TOPICA LOCAL DE LAS VIAS RESPIRATORIAS. CON UN METODO PRESENTADO EN LA INVENCION SE CONSIGUE LA LIBERACION DEL ANESTESICO A MODO DE AEROSOL SEGUN UNA DOSIS SELECCIONADA EN UN BOTE QUE CONTIENE LA COMPOSICION ANESTESICA LOCAL A PRESION EN EL SISTEMA RESPIRATORIO DE UN PACIENTE DIRECTAMENTE O A TRAVES DE UN CONDUCTO DE VENTILACION.
ES94909882T 1993-03-29 1994-03-28 Aerosol anestesico en base a lidocaina. Expired - Lifetime ES2138074T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3893093A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
ES2138074T3 true ES2138074T3 (es) 2000-01-01

Family

ID=21902722

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909882T Expired - Lifetime ES2138074T3 (es) 1993-03-29 1994-03-28 Aerosol anestesico en base a lidocaina.

Country Status (8)

Country Link
EP (1) EP0691842B1 (es)
JP (1) JP3618346B2 (es)
AT (1) ATE183919T1 (es)
AU (1) AU676025B2 (es)
CA (1) CA2156821C (es)
DE (1) DE69420401T2 (es)
ES (1) ES2138074T3 (es)
WO (1) WO1994022422A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508023A (en) * 1994-04-11 1996-04-16 The Center For Innovative Technology Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant
US5589156A (en) * 1994-05-02 1996-12-31 Henry; Richard A. Prilocaine and hydrofluourocarbon aerosol preparations
CA2218879A1 (en) * 1995-05-12 1996-11-14 Genentech, Inc. Coarse spray delivery of functional biologic materials
WO2009035646A1 (en) 2007-09-12 2009-03-19 Wolfe Tory Medical, Inc. Applicator for oropharyngeal anesthetic

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8900267D0 (en) * 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
GB9103302D0 (en) * 1991-02-16 1991-04-03 Smithkline Beecham Plc Pharmaceutical formulations
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations

Also Published As

Publication number Publication date
EP0691842B1 (en) 1999-09-01
WO1994022422A1 (en) 1994-10-13
AU6256294A (en) 1994-10-24
CA2156821C (en) 2005-02-15
DE69420401D1 (de) 1999-10-07
CA2156821A1 (en) 1994-10-13
DE69420401T2 (de) 2000-05-04
AU676025B2 (en) 1997-02-27
ATE183919T1 (de) 1999-09-15
JP3618346B2 (ja) 2005-02-09
EP0691842A1 (en) 1996-01-17
JPH08511767A (ja) 1996-12-10

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