ES2137104A1 - Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamine - Google Patents
Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamineInfo
- Publication number
- ES2137104A1 ES2137104A1 ES009700521A ES9700521A ES2137104A1 ES 2137104 A1 ES2137104 A1 ES 2137104A1 ES 009700521 A ES009700521 A ES 009700521A ES 9700521 A ES9700521 A ES 9700521A ES 2137104 A1 ES2137104 A1 ES 2137104A1
- Authority
- ES
- Spain
- Prior art keywords
- benzyloxy
- propargyl
- methylamine
- indolyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamine. This is a new process for the synthesis of N-propargyl-2- (5-benzyloxy-indolyl)-methylamine. It is based on the reductive amination of 2-(5-benzyloxy-indol)- carboxyaldehyde using propargylamine in excess followed by reaction with sodium borohydride. This results in a more effective, clean and efficient process producing higher yield (66% in three stages starting from 2-(5- benzyloxyindol)ethylcarboxylate).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700521A ES2137104B1 (en) | 1997-03-10 | 1997-03-10 | PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700521A ES2137104B1 (en) | 1997-03-10 | 1997-03-10 | PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137104A1 true ES2137104A1 (en) | 1999-12-01 |
ES2137104B1 ES2137104B1 (en) | 2000-08-16 |
Family
ID=8298577
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700521A Expired - Fee Related ES2137104B1 (en) | 1997-03-10 | 1997-03-10 | PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2137104B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2010142A6 (en) * | 1989-02-28 | 1989-10-16 | Consejo Superior Investigacion | Amino-methyl indole deriv. prepn. |
ES2013391A6 (en) * | 1989-02-08 | 1990-05-01 | Consejo Superior Investigacion | Indole derivates. |
-
1997
- 1997-03-10 ES ES9700521A patent/ES2137104B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2013391A6 (en) * | 1989-02-08 | 1990-05-01 | Consejo Superior Investigacion | Indole derivates. |
ES2010142A6 (en) * | 1989-02-28 | 1989-10-16 | Consejo Superior Investigacion | Amino-methyl indole deriv. prepn. |
Non-Patent Citations (1)
Title |
---|
European Journal Medicinal Chemistry, Vol. 26, paginas 33-41, 1991. M.A. CRUCES et al. "Acetylemic and allenic derivatives of 2-(5-benzyloxyindolyl)methylamines". Tabla 1, compuesto 5a. * |
Also Published As
Publication number | Publication date |
---|---|
ES2137104B1 (en) | 2000-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19991201 Kind code of ref document: A1 Effective date: 19991201 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20180807 |