ES2137104A1 - Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamine - Google Patents

Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamine

Info

Publication number
ES2137104A1
ES2137104A1 ES009700521A ES9700521A ES2137104A1 ES 2137104 A1 ES2137104 A1 ES 2137104A1 ES 009700521 A ES009700521 A ES 009700521A ES 9700521 A ES9700521 A ES 9700521A ES 2137104 A1 ES2137104 A1 ES 2137104A1
Authority
ES
Spain
Prior art keywords
benzyloxy
propargyl
methylamine
indolyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009700521A
Other languages
Spanish (es)
Other versions
ES2137104B1 (en
Inventor
Contelles Jose Luis Marco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9700521A priority Critical patent/ES2137104B1/en
Publication of ES2137104A1 publication Critical patent/ES2137104A1/en
Application granted granted Critical
Publication of ES2137104B1 publication Critical patent/ES2137104B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Process for the preparation of N-propargyl-2-(5-benzyloxy- indolyl)-methylamine. This is a new process for the synthesis of N-propargyl-2- (5-benzyloxy-indolyl)-methylamine. It is based on the reductive amination of 2-(5-benzyloxy-indol)- carboxyaldehyde using propargylamine in excess followed by reaction with sodium borohydride. This results in a more effective, clean and efficient process producing higher yield (66% in three stages starting from 2-(5- benzyloxyindol)ethylcarboxylate).
ES9700521A 1997-03-10 1997-03-10 PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA Expired - Fee Related ES2137104B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700521A ES2137104B1 (en) 1997-03-10 1997-03-10 PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700521A ES2137104B1 (en) 1997-03-10 1997-03-10 PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA

Publications (2)

Publication Number Publication Date
ES2137104A1 true ES2137104A1 (en) 1999-12-01
ES2137104B1 ES2137104B1 (en) 2000-08-16

Family

ID=8298577

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700521A Expired - Fee Related ES2137104B1 (en) 1997-03-10 1997-03-10 PROCEDURE FOR THE PREPARATION OF N-PROPARGIL-2- (5-BENCILOXI-INDOLIL) -METILAMINA

Country Status (1)

Country Link
ES (1) ES2137104B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2010142A6 (en) * 1989-02-28 1989-10-16 Consejo Superior Investigacion Amino-methyl indole deriv. prepn.
ES2013391A6 (en) * 1989-02-08 1990-05-01 Consejo Superior Investigacion Indole derivates.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2013391A6 (en) * 1989-02-08 1990-05-01 Consejo Superior Investigacion Indole derivates.
ES2010142A6 (en) * 1989-02-28 1989-10-16 Consejo Superior Investigacion Amino-methyl indole deriv. prepn.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
European Journal Medicinal Chemistry, Vol. 26, paginas 33-41, 1991. M.A. CRUCES et al. "Acetylemic and allenic derivatives of 2-(5-benzyloxyindolyl)methylamines". Tabla 1, compuesto 5a. *

Also Published As

Publication number Publication date
ES2137104B1 (en) 2000-08-16

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