ES2136013B1 - DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. - Google Patents

DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE.

Info

Publication number
ES2136013B1
ES2136013B1 ES9700796A ES9700796A ES2136013B1 ES 2136013 B1 ES2136013 B1 ES 2136013B1 ES 9700796 A ES9700796 A ES 9700796A ES 9700796 A ES9700796 A ES 9700796A ES 2136013 B1 ES2136013 B1 ES 2136013B1
Authority
ES
Spain
Prior art keywords
thiadiazine
derivatives
pharmacologically active
dioxide
trioxothiene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9700796A
Other languages
Spanish (es)
Other versions
ES2136013A1 (en
Inventor
Noverola Salvador Vega
Martin Juan Antonio Diaz
Plaza Esther Arranz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9700796A priority Critical patent/ES2136013B1/en
Publication of ES2136013A1 publication Critical patent/ES2136013A1/en
Application granted granted Critical
Publication of ES2136013B1 publication Critical patent/ES2136013B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

Derivados de tieno y pirazolo [1, 2, 4] tiadiazina - 1, , - dióxido farmacológicamente activos.La presente invención se refiere a derivados de tieno- y pirazolo [1.2,4] tiadiazina - 1,1 - dióxido farmacológicamente activos, de fórmula general (I) donde: X representa un átomode nitrógeno, de azufre o un grupo NH, N-alquilo, N-arilalquilo o C-R{sub,3 ; Y representa un átomo de nitrógeno, de azufre o un grupo NH, N-alquilo, N-arilalquilo, CH o C-R{sub,3 y Z es un átomo de nitrógeno, de azufre o un grupo CH o C-R{sub,3 ; entre ellos se incluyen derivados del sistema de2H, 4H-1,1,3 - trioxotieno [2,3-e] [1,2,4] tiadiazina, del sistema de 2H, 4H-1, 1, 3 - trioxotieno [3, 4-e][1,2,4] tiadiazina, del sistema de 2H, 4H-1,1,3-trioxotieno [3,2-e][1,2,4] tiadiazina, del sistema de 2H, 4H-1,1,3 - trioxopirazolo[4,3-e][1,2,4] tiadiazina, del sistema de H, 4H-1,1,3- trioxopirazolo [3,4-e] [1,2,4] tiadiazina, así como su procedimiento de obtención. También incluye composiciones farmacéuticas que contengancomo ingrediente activo, al menos uno de los compuestos citados en cualquiera de las reivindicaciones1 a 11, o una de sus sales farmacológicamente aceptables, yque resultan de utilidad, entre otras aplicaciones, como agentes psicótropos, antihipertensores, antiasmáticos y/o antivirales frente al VIH-1 y VIH-2.Pharmacologically active thieno and pyrazolo [1,2,4] thiadiazine-1,, - dioxide derivatives. The present invention relates to pharmacologically active thieno- and pyrazolo [1.2,4] thiadiazine-1,1-dioxide derivatives of general formula (I) where: X represents a nitrogen, sulfur atom or a NH, N-alkyl, N-arylalkyl or CR {sub, 3 group; Y represents a nitrogen, sulfur or NH, N-alkyl, N-arylalkyl, CH or C-R {sub, 3 group and Z is a nitrogen, sulfur or CH or C-R {sub, 3 group; These include derivatives of the 2H, 4H-1,1,3-trioxothiene [2,3-e] [1,2,4] thiadiazine system, from the 2H, 4H-1, 1, 3-trioxothiene system [3 , 4-e] [1,2,4] thiadiazine, from the 2H system, 4H-1,1,3-trioxothiene [3,2-e] [1,2,4] thiadiazine, from the 2H system, 4H -1,1,3-trioxopyrazolo [4,3-e] [1,2,4] thiadiazine, H-system, 4H-1,1,3-trioxopyrazolo [3,4-e] [1,2, 4] thiadiazine, as well as its obtaining procedure. It also includes pharmaceutical compositions containing, as an active ingredient, at least one of the compounds mentioned in any one of claims 1 to 11, or one of its pharmacologically acceptable salts, and which are useful, among other applications, as psychotropic agents, antihypertensives, anti-asthmatics and / or antivirals against HIV-1 and HIV-2.

ES9700796A 1997-04-15 1997-04-15 DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. Expired - Fee Related ES2136013B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700796A ES2136013B1 (en) 1997-04-15 1997-04-15 DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700796A ES2136013B1 (en) 1997-04-15 1997-04-15 DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE.

Publications (2)

Publication Number Publication Date
ES2136013A1 ES2136013A1 (en) 1999-11-01
ES2136013B1 true ES2136013B1 (en) 2000-07-01

Family

ID=8298959

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700796A Expired - Fee Related ES2136013B1 (en) 1997-04-15 1997-04-15 DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE.

Country Status (1)

Country Link
ES (1) ES2136013B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100519565C (en) * 2007-06-22 2009-07-29 山东大学 N1, N3-disubstituted-7-methylpyrazole [4,5-e] [2,1,3] thiadiazin-2, 2, 4-triketone derivatives, their preparation method and application
TWI490214B (en) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 Benzene or thiophene derivative and use thereof as vap-1 inhibitor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990077319A (en) * 1996-01-17 1999-10-25 한센 핀 베네드, 안네 제헤르 Condensed 1,2,4-thiadiazine and condensed 1,4-thiazine derivatives, processes for their preparation and their use

Also Published As

Publication number Publication date
ES2136013A1 (en) 1999-11-01

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