ES2136013B1 - DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. - Google Patents
DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE.Info
- Publication number
- ES2136013B1 ES2136013B1 ES9700796A ES9700796A ES2136013B1 ES 2136013 B1 ES2136013 B1 ES 2136013B1 ES 9700796 A ES9700796 A ES 9700796A ES 9700796 A ES9700796 A ES 9700796A ES 2136013 B1 ES2136013 B1 ES 2136013B1
- Authority
- ES
- Spain
- Prior art keywords
- thiadiazine
- derivatives
- pharmacologically active
- dioxide
- trioxothiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
Derivados de tieno y pirazolo [1, 2, 4] tiadiazina - 1, , - dióxido farmacológicamente activos.La presente invención se refiere a derivados de tieno- y pirazolo [1.2,4] tiadiazina - 1,1 - dióxido farmacológicamente activos, de fórmula general (I) donde: X representa un átomode nitrógeno, de azufre o un grupo NH, N-alquilo, N-arilalquilo o C-R{sub,3 ; Y representa un átomo de nitrógeno, de azufre o un grupo NH, N-alquilo, N-arilalquilo, CH o C-R{sub,3 y Z es un átomo de nitrógeno, de azufre o un grupo CH o C-R{sub,3 ; entre ellos se incluyen derivados del sistema de2H, 4H-1,1,3 - trioxotieno [2,3-e] [1,2,4] tiadiazina, del sistema de 2H, 4H-1, 1, 3 - trioxotieno [3, 4-e][1,2,4] tiadiazina, del sistema de 2H, 4H-1,1,3-trioxotieno [3,2-e][1,2,4] tiadiazina, del sistema de 2H, 4H-1,1,3 - trioxopirazolo[4,3-e][1,2,4] tiadiazina, del sistema de H, 4H-1,1,3- trioxopirazolo [3,4-e] [1,2,4] tiadiazina, así como su procedimiento de obtención. También incluye composiciones farmacéuticas que contengancomo ingrediente activo, al menos uno de los compuestos citados en cualquiera de las reivindicaciones1 a 11, o una de sus sales farmacológicamente aceptables, yque resultan de utilidad, entre otras aplicaciones, como agentes psicótropos, antihipertensores, antiasmáticos y/o antivirales frente al VIH-1 y VIH-2.Pharmacologically active thieno and pyrazolo [1,2,4] thiadiazine-1,, - dioxide derivatives. The present invention relates to pharmacologically active thieno- and pyrazolo [1.2,4] thiadiazine-1,1-dioxide derivatives of general formula (I) where: X represents a nitrogen, sulfur atom or a NH, N-alkyl, N-arylalkyl or CR {sub, 3 group; Y represents a nitrogen, sulfur or NH, N-alkyl, N-arylalkyl, CH or C-R {sub, 3 group and Z is a nitrogen, sulfur or CH or C-R {sub, 3 group; These include derivatives of the 2H, 4H-1,1,3-trioxothiene [2,3-e] [1,2,4] thiadiazine system, from the 2H, 4H-1, 1, 3-trioxothiene system [3 , 4-e] [1,2,4] thiadiazine, from the 2H system, 4H-1,1,3-trioxothiene [3,2-e] [1,2,4] thiadiazine, from the 2H system, 4H -1,1,3-trioxopyrazolo [4,3-e] [1,2,4] thiadiazine, H-system, 4H-1,1,3-trioxopyrazolo [3,4-e] [1,2, 4] thiadiazine, as well as its obtaining procedure. It also includes pharmaceutical compositions containing, as an active ingredient, at least one of the compounds mentioned in any one of claims 1 to 11, or one of its pharmacologically acceptable salts, and which are useful, among other applications, as psychotropic agents, antihypertensives, anti-asthmatics and / or antivirals against HIV-1 and HIV-2.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700796A ES2136013B1 (en) | 1997-04-15 | 1997-04-15 | DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700796A ES2136013B1 (en) | 1997-04-15 | 1997-04-15 | DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2136013A1 ES2136013A1 (en) | 1999-11-01 |
ES2136013B1 true ES2136013B1 (en) | 2000-07-01 |
Family
ID=8298959
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700796A Expired - Fee Related ES2136013B1 (en) | 1997-04-15 | 1997-04-15 | DERIVATIVES OF TIENO AND PIRAZOLO (1,2,4) THIADIAZINE-1,1-DIOXIDE PHARMACOLOGICALLY ACTIVE. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2136013B1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100519565C (en) * | 2007-06-22 | 2009-07-29 | 山东大学 | N1, N3-disubstituted-7-methylpyrazole [4,5-e] [2,1,3] thiadiazin-2, 2, 4-triketone derivatives, their preparation method and application |
TWI490214B (en) | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | Benzene or thiophene derivative and use thereof as vap-1 inhibitor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR19990077319A (en) * | 1996-01-17 | 1999-10-25 | 한센 핀 베네드, 안네 제헤르 | Condensed 1,2,4-thiadiazine and condensed 1,4-thiazine derivatives, processes for their preparation and their use |
-
1997
- 1997-04-15 ES ES9700796A patent/ES2136013B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2136013A1 (en) | 1999-11-01 |
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Legal Events
Date | Code | Title | Description |
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EC2A | Search report published |
Date of ref document: 19991101 Kind code of ref document: A1 Effective date: 19991101 |
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FD2A | Announcement of lapse in spain |
Effective date: 20110809 |