ES2134128A1 - Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo. - Google Patents
Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo.Info
- Publication number
- ES2134128A1 ES2134128A1 ES09700080A ES9700080A ES2134128A1 ES 2134128 A1 ES2134128 A1 ES 2134128A1 ES 09700080 A ES09700080 A ES 09700080A ES 9700080 A ES9700080 A ES 9700080A ES 2134128 A1 ES2134128 A1 ES 2134128A1
- Authority
- ES
- Spain
- Prior art keywords
- antibiotics
- pharmaceutical compositions
- reducing residual
- residual levels
- solvents present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un procedimiento de reducción de los niveles residuales de disolventes presentes en las composiciones farmacéuticas, en particular en antibióticos y antibióticos obtenidos según el mismo. El procedimiento consiste en una eliminación de disolventes, en particular de cloruro de metileno, utilizados en la purificación de antibióticos, tipo ampicilina o amoxicilina, anteriormente a su cristalización, mediante una evaporación a vacío con recogida durante breves segundos del destilado inicial y a baja temperatura. Se obtienen antibióticos con brazas de cloruro de metileno inferiores a 3 ppm.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700080A ES2134128B1 (es) | 1997-01-17 | 1997-01-17 | Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700080A ES2134128B1 (es) | 1997-01-17 | 1997-01-17 | Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2134128A1 true ES2134128A1 (es) | 1999-09-16 |
ES2134128B1 ES2134128B1 (es) | 2000-05-01 |
Family
ID=8297893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700080A Expired - Fee Related ES2134128B1 (es) | 1997-01-17 | 1997-01-17 | Un procedimiento de reduccion de los niveles residuales de disolventes, presentes en las composiciones farmaceuticas, en particular en los antibioticos y antibioticos obtenidos segun el mismo. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2134128B1 (es) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB572818A (en) * | 1943-09-17 | 1945-10-29 | Therapeutic Res Corp Of Great | Therapeutic material and method of producing same |
GB1070799A (en) * | 1964-06-04 | 1967-06-01 | Le Nii Antibiotikov | Isolation of the antibiotic levorin from a fermentation broth |
ES452258A1 (es) * | 1976-09-22 | 1977-11-01 | Ferrer Int | Procedimiento de obtencion de un derivado de n-(2-dietilami-noetil)-4-amino-5-bromo-0-anisamida. |
ES8402571A1 (es) * | 1982-12-09 | 1984-02-01 | Ferrer Int | Procedimiento de obtencion de un derivado de la l-alanil-l-prolina. |
ES8706691A1 (es) * | 1986-04-10 | 1987-07-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de l-(tienil-3-oxi) alquil penicilinas |
EP0273156A2 (en) * | 1986-12-23 | 1988-07-06 | Giovanni Bonfanti | Method for producing pure crystalline products |
-
1997
- 1997-01-17 ES ES9700080A patent/ES2134128B1/es not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB572818A (en) * | 1943-09-17 | 1945-10-29 | Therapeutic Res Corp Of Great | Therapeutic material and method of producing same |
GB1070799A (en) * | 1964-06-04 | 1967-06-01 | Le Nii Antibiotikov | Isolation of the antibiotic levorin from a fermentation broth |
ES452258A1 (es) * | 1976-09-22 | 1977-11-01 | Ferrer Int | Procedimiento de obtencion de un derivado de n-(2-dietilami-noetil)-4-amino-5-bromo-0-anisamida. |
ES8402571A1 (es) * | 1982-12-09 | 1984-02-01 | Ferrer Int | Procedimiento de obtencion de un derivado de la l-alanil-l-prolina. |
ES8706691A1 (es) * | 1986-04-10 | 1987-07-01 | Consejo Superior Investigacion | Procedimiento para la preparacion de l-(tienil-3-oxi) alquil penicilinas |
EP0273156A2 (en) * | 1986-12-23 | 1988-07-06 | Giovanni Bonfanti | Method for producing pure crystalline products |
Also Published As
Publication number | Publication date |
---|---|
ES2134128B1 (es) | 2000-05-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990916 Kind code of ref document: A1 Effective date: 19990916 |
|
FD1A | Patent lapsed |
Effective date: 20060118 |