ES2129356B1 - PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. - Google Patents

PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS.

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Publication number
ES2129356B1
ES2129356B1 ES9700651A ES9700651A ES2129356B1 ES 2129356 B1 ES2129356 B1 ES 2129356B1 ES 9700651 A ES9700651 A ES 9700651A ES 9700651 A ES9700651 A ES 9700651A ES 2129356 B1 ES2129356 B1 ES 2129356B1
Authority
ES
Spain
Prior art keywords
phase
procedure
microcapsules
pharmaceutical form
terms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9700651A
Other languages
Spanish (es)
Other versions
ES2129356A1 (en
Inventor
Cayuela Miguel Angel Asin
Nunez Jesus Garcia
Buruaga Eulalia Ferret
Manubens Pere Tarin
Tadeo Rosa Arola
Pitarch Montserrat Rutllan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Iberica SA
Original Assignee
Pierre Fabre Iberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Iberica SA filed Critical Pierre Fabre Iberica SA
Priority to ES9700651A priority Critical patent/ES2129356B1/en
Publication of ES2129356A1 publication Critical patent/ES2129356A1/en
Application granted granted Critical
Publication of ES2129356B1 publication Critical patent/ES2129356B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

Forma farmacéutica de liberación prolongada y procedimiento para su obtención; la forma comprende microcápsulas constituidas por una pared polimérica que recubre un núcleo con uno o más principios activos que forman complejo con una resina de intercambio iónico; la pared polimérica está formada por una sola capa de una mezcla de uno o más polímeros pH independientes e insolubles y uno o más polímeros pH dependientes, solubles en medio acuoso a partir de un valor de pH mayor de 5. El procedimiento comprende: disolución de un polímero pH independiente, otro pH dependiente y un plastificante; suspensión de un complejo formado por el principio activo y la resina de intercambio iónico, obteniendo una primera fase; formación de una segunda fase por disolución de un aceite en un tensioactivo; emulsionado de la primera fase en la segunda fase; evaporación del disolvente formando las microcápsulas; y lavado de las microcápsulas.Long-release pharmaceutical form and procedure for obtaining it; the form comprises microcapsules consisting of a polymeric wall that covers a core with one or more active ingredients that complex with an ion exchange resin; the polymeric wall is formed by a single layer of a mixture of one or more independent and insoluble pH polymers and one or more pH dependent polymers, soluble in aqueous medium from a pH value greater than 5. The procedure includes: dissolution of a pH independent polymer, another pH dependent and a plasticizer; suspension of a complex formed by the active principle and the ion exchange resin, obtaining a first phase; formation of a second phase by dissolving an oil in a surfactant; emulsified from the first phase to the second phase; solvent evaporation forming the microcapsules; and washing the microcapsules.

ES9700651A 1997-03-26 1997-03-26 PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. Expired - Fee Related ES2129356B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9700651A ES2129356B1 (en) 1997-03-26 1997-03-26 PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9700651A ES2129356B1 (en) 1997-03-26 1997-03-26 PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS.

Publications (2)

Publication Number Publication Date
ES2129356A1 ES2129356A1 (en) 1999-06-01
ES2129356B1 true ES2129356B1 (en) 2000-01-16

Family

ID=8298751

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9700651A Expired - Fee Related ES2129356B1 (en) 1997-03-26 1997-03-26 PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS.

Country Status (1)

Country Link
ES (1) ES2129356B1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2643222B2 (en) * 1988-02-03 1997-08-20 エーザイ株式会社 Multi-layer granules
SE509029C2 (en) * 1988-08-16 1998-11-30 Ss Pharmaceutical Co Long-acting diclofenac sodium preparations
DE69017915T2 (en) * 1989-10-26 1995-07-27 Nippon Shinyaku Co Ltd PREPARATION FOR THE STOMACH.
JPH0674206B2 (en) * 1989-12-28 1994-09-21 田辺製薬株式会社 Controlled release formulation and process for producing

Also Published As

Publication number Publication date
ES2129356A1 (en) 1999-06-01

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