ES2129356B1 - PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. - Google Patents
PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS.Info
- Publication number
- ES2129356B1 ES2129356B1 ES9700651A ES9700651A ES2129356B1 ES 2129356 B1 ES2129356 B1 ES 2129356B1 ES 9700651 A ES9700651 A ES 9700651A ES 9700651 A ES9700651 A ES 9700651A ES 2129356 B1 ES2129356 B1 ES 2129356B1
- Authority
- ES
- Spain
- Prior art keywords
- phase
- procedure
- microcapsules
- pharmaceutical form
- terms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
Forma farmacéutica de liberación prolongada y procedimiento para su obtención; la forma comprende microcápsulas constituidas por una pared polimérica que recubre un núcleo con uno o más principios activos que forman complejo con una resina de intercambio iónico; la pared polimérica está formada por una sola capa de una mezcla de uno o más polímeros pH independientes e insolubles y uno o más polímeros pH dependientes, solubles en medio acuoso a partir de un valor de pH mayor de 5. El procedimiento comprende: disolución de un polímero pH independiente, otro pH dependiente y un plastificante; suspensión de un complejo formado por el principio activo y la resina de intercambio iónico, obteniendo una primera fase; formación de una segunda fase por disolución de un aceite en un tensioactivo; emulsionado de la primera fase en la segunda fase; evaporación del disolvente formando las microcápsulas; y lavado de las microcápsulas.Long-release pharmaceutical form and procedure for obtaining it; the form comprises microcapsules consisting of a polymeric wall that covers a core with one or more active ingredients that complex with an ion exchange resin; the polymeric wall is formed by a single layer of a mixture of one or more independent and insoluble pH polymers and one or more pH dependent polymers, soluble in aqueous medium from a pH value greater than 5. The procedure includes: dissolution of a pH independent polymer, another pH dependent and a plasticizer; suspension of a complex formed by the active principle and the ion exchange resin, obtaining a first phase; formation of a second phase by dissolving an oil in a surfactant; emulsified from the first phase to the second phase; solvent evaporation forming the microcapsules; and washing the microcapsules.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700651A ES2129356B1 (en) | 1997-03-26 | 1997-03-26 | PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9700651A ES2129356B1 (en) | 1997-03-26 | 1997-03-26 | PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2129356A1 ES2129356A1 (en) | 1999-06-01 |
ES2129356B1 true ES2129356B1 (en) | 2000-01-16 |
Family
ID=8298751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9700651A Expired - Fee Related ES2129356B1 (en) | 1997-03-26 | 1997-03-26 | PHARMACEUTICAL FORM OF PROLONGED RELEASE AND PROCEDURE FOR ITS OR TERMS. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2129356B1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2643222B2 (en) * | 1988-02-03 | 1997-08-20 | エーザイ株式会社 | Multi-layer granules |
SE509029C2 (en) * | 1988-08-16 | 1998-11-30 | Ss Pharmaceutical Co | Long-acting diclofenac sodium preparations |
DE69017915T2 (en) * | 1989-10-26 | 1995-07-27 | Nippon Shinyaku Co Ltd | PREPARATION FOR THE STOMACH. |
JPH0674206B2 (en) * | 1989-12-28 | 1994-09-21 | 田辺製薬株式会社 | Controlled release formulation and process for producing |
-
1997
- 1997-03-26 ES ES9700651A patent/ES2129356B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2129356A1 (en) | 1999-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19990601 Kind code of ref document: A1 Effective date: 19990601 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20161214 |