ES2124954T3 - CYCLOHEXAPEPTIDES AND THEIR MIXTURES, PROCEDURE FOR THEIR PREPARATION AS WELL AS THEIR USE. - Google Patents

CYCLOHEXAPEPTIDES AND THEIR MIXTURES, PROCEDURE FOR THEIR PREPARATION AS WELL AS THEIR USE.

Info

Publication number
ES2124954T3
ES2124954T3 ES95119338T ES95119338T ES2124954T3 ES 2124954 T3 ES2124954 T3 ES 2124954T3 ES 95119338 T ES95119338 T ES 95119338T ES 95119338 T ES95119338 T ES 95119338T ES 2124954 T3 ES2124954 T3 ES 2124954T3
Authority
ES
Spain
Prior art keywords
val
xaa
tyr
ala
cyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95119338T
Other languages
Spanish (es)
Inventor
Stephan Dr Henke
Birgit Dr Jordan
Jochen Dr Knolle
Leander Dr Lauffer
Susanne Feiertag
Karl-Heinz Dr Wiesmuller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2124954T3 publication Critical patent/ES2124954T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cyclic peptides of formula cyclo(A-B-C-E-F-(D)-Ala) (I) and their salts are new, where A, B, C, E and F = natural amino acids other than Cys and Trp. More specifically, (I) are of formulae: cyclo(Val-Val-Xaa-Val-Val-D-Ala), cyclo(Val-Tyr-Xaa-Val-Tyr-D-Ala) and cyclo(Tyr-Val-Xaa-Tyr-Val-D-Ala), where Xaa = a natural amino acid other than Cys and Trp.
ES95119338T 1994-12-13 1995-12-07 CYCLOHEXAPEPTIDES AND THEIR MIXTURES, PROCEDURE FOR THEIR PREPARATION AS WELL AS THEIR USE. Expired - Lifetime ES2124954T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4444260A DE4444260A1 (en) 1994-12-13 1994-12-13 Cyclohexapeptides and their mixtures, process for their preparation and their use

Publications (1)

Publication Number Publication Date
ES2124954T3 true ES2124954T3 (en) 1999-02-16

Family

ID=6535622

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95119338T Expired - Lifetime ES2124954T3 (en) 1994-12-13 1995-12-07 CYCLOHEXAPEPTIDES AND THEIR MIXTURES, PROCEDURE FOR THEIR PREPARATION AS WELL AS THEIR USE.

Country Status (11)

Country Link
US (1) US5869447A (en)
EP (1) EP0717048B1 (en)
JP (1) JP3825491B2 (en)
CN (1) CN1206239C (en)
AT (1) ATE171711T1 (en)
AU (1) AU709360B2 (en)
CA (1) CA2165039C (en)
DE (2) DE4444260A1 (en)
DK (1) DK0717048T3 (en)
ES (1) ES2124954T3 (en)
RU (1) RU2163242C2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080719A (en) * 1996-02-23 2000-06-27 Hoechst Aktiengesellschaft Cyclohexapeptides and their mixtures, a process for preparing them, and their use
AUPP616498A0 (en) 1998-09-25 1998-10-15 University Of Queensland, The Synthesis of cyclic peptides
KR20090041360A (en) * 2006-02-27 2009-04-28 테크니쉐 유니베르시테트 뮌헨 Cancer imaging and treatment
US9168156B2 (en) * 2006-04-04 2015-10-27 Smith & Nephew, Inc. Trial coupler systems and methods
WO2013054329A1 (en) * 2011-10-10 2013-04-18 Yeda Research And Development Co. Ltd. Toll-like receptor 4 (tlr-4) agonist peptides for modulating tlr-4 mediated immune response
CA2805989A1 (en) 2010-07-19 2012-01-26 Yeda Research And Development Co. Ltd. Peptides based on the transmembrane domain of a toll-like receptor (tlr) for treatment of tlr-mediated diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7708136L (en) * 1976-08-02 1978-02-03 Merck & Co Inc CYCLIC HEXAPEPTIDES
US4659691A (en) * 1985-02-08 1987-04-21 Merck & Co., Inc. Novel cyclic Hexapeptide LHRH antagonists
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NZ243090A (en) * 1991-06-18 1993-11-25 Lilly Co Eli Method of identifying active peptides and synthesis of peptide mixtures with a known amino acid in the last coupled position
DE4322330A1 (en) * 1992-08-31 1994-03-03 Behringwerke Ag Use of the IL-4 receptor for the therapy, prophylaxis and diagnosis of allergic, viral, parasitic and bacterial diseases as well as fungal infections
UA43823C2 (en) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг PHARMACEUTICAL COMPOSITION FOR INTEGRIN INHIBITION <font face = "Symbol"> a </font> <sub> V </sub> <font face = "Symbol"> b </font> <sub> 3 </sub> cell adhesion mammal WAY treatment and prevention of diseases associated with cell adhesion DISORDERS, METHOD FOR BINDING LOCK integrin fibrinogen, a composition for wound healing
WO1995001800A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation Cyclic semi-random peptide libraries

Also Published As

Publication number Publication date
CA2165039C (en) 2008-02-05
CN1206239C (en) 2005-06-15
JPH08208694A (en) 1996-08-13
US5869447A (en) 1999-02-09
DK0717048T3 (en) 1999-06-21
ATE171711T1 (en) 1998-10-15
AU709360B2 (en) 1999-08-26
EP0717048A1 (en) 1996-06-19
EP0717048B1 (en) 1998-09-30
AU4034095A (en) 1996-06-20
CN1132210A (en) 1996-10-02
RU2163242C2 (en) 2001-02-20
JP3825491B2 (en) 2006-09-27
CA2165039A1 (en) 1996-06-14
DE59503776D1 (en) 1998-11-05
DE4444260A1 (en) 1996-06-20

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