ES2119614A1 - Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect. - Google Patents

Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect.

Info

Publication number
ES2119614A1
ES2119614A1 ES09500272A ES9500272A ES2119614A1 ES 2119614 A1 ES2119614 A1 ES 2119614A1 ES 09500272 A ES09500272 A ES 09500272A ES 9500272 A ES9500272 A ES 9500272A ES 2119614 A1 ES2119614 A1 ES 2119614A1
Authority
ES
Spain
Prior art keywords
agents
hypoxia
reducing
smooth muscle
pharmacological compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09500272A
Other languages
Spanish (es)
Other versions
ES2119614B1 (en
Inventor
Barneo Jose Lopez
Lopez Juan Urena
Obregon Alfredo Franco
Orozco Antonio Castellano
Laseca Rafael Montoro
Pachon Antonio Molina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Original Assignee
Universidad de Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Sevilla filed Critical Universidad de Sevilla
Priority to ES9500272A priority Critical patent/ES2119614B1/en
Publication of ES2119614A1 publication Critical patent/ES2119614A1/en
Application granted granted Critical
Publication of ES2119614B1 publication Critical patent/ES2119614B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect. The use in pharmacological preparations of reducing agents, and in general those producing hypoxia which, either alone or linked by physical mixing or chemical bonding to substances that carry them and direct them towards their targets, and especially to calcium antagonists (such as nifedipine, diltiazem or verapamil), interact with the calcium channels of the cellular membrane and cause a decrease in the entry of the cation Ca2+ into the cells, is proposed as new. Emphasis should be placed on the action of these agents on the calcium channels of the smooth muscle fibre, where they cause a decrease in the flow of the cation to the cytosol, and consequently relaxation. It has applications in the pharmaceutical industry and in clinical medicine, for the manufacture of pharmacological compositions for the treatment of pathological situations due to an increase in the contractility of the smooth muscle fibre, such as hypotensors (by relaxation of the arterial smooth muscle) or inhibitors of intestinal or uterine motility.
ES9500272A 1995-02-08 1995-02-08 USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA. Expired - Fee Related ES2119614B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9500272A ES2119614B1 (en) 1995-02-08 1995-02-08 USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9500272A ES2119614B1 (en) 1995-02-08 1995-02-08 USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA.

Publications (2)

Publication Number Publication Date
ES2119614A1 true ES2119614A1 (en) 1998-10-01
ES2119614B1 ES2119614B1 (en) 1999-07-01

Family

ID=8289449

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9500272A Expired - Fee Related ES2119614B1 (en) 1995-02-08 1995-02-08 USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA.

Country Status (1)

Country Link
ES (1) ES2119614B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080448A (en) * 1974-11-13 1978-03-21 Mirsky Louis H Method of treating cellular stress
EP0039130A1 (en) * 1980-04-28 1981-11-04 Betz Europe, Inc. Aromatic compounds as oxygen scavengers in an aqueous medium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080448A (en) * 1974-11-13 1978-03-21 Mirsky Louis H Method of treating cellular stress
EP0039130A1 (en) * 1980-04-28 1981-11-04 Betz Europe, Inc. Aromatic compounds as oxygen scavengers in an aqueous medium

Also Published As

Publication number Publication date
ES2119614B1 (en) 1999-07-01

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