ES2119614A1 - Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect. - Google Patents
Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect.Info
- Publication number
- ES2119614A1 ES2119614A1 ES09500272A ES9500272A ES2119614A1 ES 2119614 A1 ES2119614 A1 ES 2119614A1 ES 09500272 A ES09500272 A ES 09500272A ES 9500272 A ES9500272 A ES 9500272A ES 2119614 A1 ES2119614 A1 ES 2119614A1
- Authority
- ES
- Spain
- Prior art keywords
- agents
- hypoxia
- reducing
- smooth muscle
- pharmacological compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Use in pharmacological compositions of agents with a hypoxia-reducing or -inducing effect. The use in pharmacological preparations of reducing agents, and in general those producing hypoxia which, either alone or linked by physical mixing or chemical bonding to substances that carry them and direct them towards their targets, and especially to calcium antagonists (such as nifedipine, diltiazem or verapamil), interact with the calcium channels of the cellular membrane and cause a decrease in the entry of the cation Ca2+ into the cells, is proposed as new. Emphasis should be placed on the action of these agents on the calcium channels of the smooth muscle fibre, where they cause a decrease in the flow of the cation to the cytosol, and consequently relaxation. It has applications in the pharmaceutical industry and in clinical medicine, for the manufacture of pharmacological compositions for the treatment of pathological situations due to an increase in the contractility of the smooth muscle fibre, such as hypotensors (by relaxation of the arterial smooth muscle) or inhibitors of intestinal or uterine motility.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9500272A ES2119614B1 (en) | 1995-02-08 | 1995-02-08 | USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9500272A ES2119614B1 (en) | 1995-02-08 | 1995-02-08 | USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2119614A1 true ES2119614A1 (en) | 1998-10-01 |
ES2119614B1 ES2119614B1 (en) | 1999-07-01 |
Family
ID=8289449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9500272A Expired - Fee Related ES2119614B1 (en) | 1995-02-08 | 1995-02-08 | USE IN PHARMACOLOGICAL COMPOSITIONS OF AGENTS WITH A REDUCING OR INDUCING EFFECT OF HYPOXIA. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2119614B1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4080448A (en) * | 1974-11-13 | 1978-03-21 | Mirsky Louis H | Method of treating cellular stress |
EP0039130A1 (en) * | 1980-04-28 | 1981-11-04 | Betz Europe, Inc. | Aromatic compounds as oxygen scavengers in an aqueous medium |
-
1995
- 1995-02-08 ES ES9500272A patent/ES2119614B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4080448A (en) * | 1974-11-13 | 1978-03-21 | Mirsky Louis H | Method of treating cellular stress |
EP0039130A1 (en) * | 1980-04-28 | 1981-11-04 | Betz Europe, Inc. | Aromatic compounds as oxygen scavengers in an aqueous medium |
Also Published As
Publication number | Publication date |
---|---|
ES2119614B1 (en) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 19981001 Kind code of ref document: A1 Effective date: 19981001 |
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FD2A | Announcement of lapse in spain |
Effective date: 20150826 |