ES2116906B1 - MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS. - Google Patents

MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS.

Info

Publication number
ES2116906B1
ES2116906B1 ES9600750A ES9600750A ES2116906B1 ES 2116906 B1 ES2116906 B1 ES 2116906B1 ES 9600750 A ES9600750 A ES 9600750A ES 9600750 A ES9600750 A ES 9600750A ES 2116906 B1 ES2116906 B1 ES 2116906B1
Authority
ES
Spain
Prior art keywords
tumors
antibody
immunized
cells
monotional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9600750A
Other languages
Spanish (es)
Other versions
ES2116906A1 (en
Inventor
Avila Miguel Quintanilla
Amat Carlos Gamallo
Solinis Alberto Gandarillas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Autonoma de Madrid filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to ES9600750A priority Critical patent/ES2116906B1/en
Priority to PCT/ES1997/000078 priority patent/WO1997036930A1/en
Publication of ES2116906A1 publication Critical patent/ES2116906A1/en
Application granted granted Critical
Publication of ES2116906B1 publication Critical patent/ES2116906B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells

Abstract

ANTICUERPO MONOCLONAL PC2.27 ASOCIADO A TUMORES. LA INVENCION ES, ESPECIFICAMENTE, UN LINEA CELULAR DE HIBRIDOMA, DENOMINADA COMO GQPC2.27, QUE PRODUCE UN ANTICUERPO IGM, DENOMINADO ABREVIADAMENTE PC2.97, QUE RECONOCE UN ANTIGENO LOCALIZADO EN EL CITOESQUELETO CELULAR DE PESO MOLECULAR APARENTE: 56 KDA (RATON) Y 51 KDA (HUMANO). EL HIDRODOMA FUE OBTENIDO POR LA FUSION DE CELULAS EXTRAIDAS DEL BRAZO DE RATAS WISTAR INMUNIZADAS Y DE CELULAS DE MIELOMA DE LA LINEA ESTABLECIDA P3X63-AG8653. LAS RATAS FUERON INMUNIZADAS CON CELULAS ENTERAS DE EPIDERMIS DE RATON TRANSFORMADAS IN VITRO POR EL CARCINOGENO DIMETILBENZANTRACENO (LINEA CELULAR PDV).MONOCLONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS. THE INVENTION IS, SPECIFICALLY, A CELL LINE OF HYBRIDOMA, CALLED AS GQPC2.27, WHICH PRODUCES AN IGM ANTIBODY, CALLED abbreviated PC2.97, THAT RECOGNIZES AN ANTIGEN LOCATED IN THE CELLULAR CELLULAR 56-CELL SKELETON. 51 KDA (HUMAN). THE HYDRODOMA WAS OBTAINED BY THE FUSION OF CELLS EXTRACTED FROM THE ARM OF IMMUNIZED WISTAR RATS AND OF MYELOMA CELLS FROM THE ESTABLISHED LINE P3X63-AG8653. RATS WERE IMMUNIZED WITH WHOLE CELLS OF MOUSE EPIDERMIS TRANSFORMED IN VITRO BY THE CARCINOGEN DIMETILBENZANTRACENO (PDV CELL LINE).

ES9600750A 1996-03-28 1996-03-28 MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS. Expired - Lifetime ES2116906B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9600750A ES2116906B1 (en) 1996-03-28 1996-03-28 MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS.
PCT/ES1997/000078 WO1997036930A1 (en) 1996-03-28 1997-03-24 Tumor-associated monoclonal antibody pc2.27

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9600750A ES2116906B1 (en) 1996-03-28 1996-03-28 MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS.

Publications (2)

Publication Number Publication Date
ES2116906A1 ES2116906A1 (en) 1998-07-16
ES2116906B1 true ES2116906B1 (en) 1999-03-01

Family

ID=8294356

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9600750A Expired - Lifetime ES2116906B1 (en) 1996-03-28 1996-03-28 MONOTIONAL ANTIBODY PC2.27 ASSOCIATED WITH TUMORS.

Country Status (2)

Country Link
ES (1) ES2116906B1 (en)
WO (1) WO1997036930A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722895A (en) * 1984-09-25 1988-02-02 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Synthetic peptides for the production of specific keratin protein antibodies
US5158893A (en) * 1986-12-11 1992-10-27 Peralta Cancer Research Institute Methods and compositions for screening carcinomas
SE470273B (en) * 1990-09-24 1993-12-20 Idl Immunodeveloplab Ab Cytokeratin fragments, their preparation and use, production of monoclonal antibodies and test kits for epithelial cancer

Also Published As

Publication number Publication date
WO1997036930A1 (en) 1997-10-09
ES2116906A1 (en) 1998-07-16

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