ES2105971B1 - ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION. - Google Patents
ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION.Info
- Publication number
- ES2105971B1 ES2105971B1 ES9501567A ES9501567A ES2105971B1 ES 2105971 B1 ES2105971 B1 ES 2105971B1 ES 9501567 A ES9501567 A ES 9501567A ES 9501567 A ES9501567 A ES 9501567A ES 2105971 B1 ES2105971 B1 ES 2105971B1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxybenzoate
- antibiotic
- inflammatory composition
- polyethylene glycol
- otic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPOSICION ANTIBIOTICA/ANTIINFLAMATORIA DE APLICACION OTICA COMPRENDE: 0.1-0.4 G DE CIPROFLOXACINO, 0.2-1.5 G DE HIDROCORTISONA, 0.3-0.8 G DE ACIDO LACTICO AL 20%; 0.3-0.6 G DE ACIDO CLORHIDRICO 1M, 1-3 G DE GLUCOSA, 1-3 G DE UN VISCOSIZANTE (PREFERIBLEMENTE POLIVINILPIRROLIDONA), 30-60 G DE UN CODISOLVENTE (PREFERIBLEMENTE PROPILENGLICOL O POLIETILENGLICOL), 1-3 G DE POLISORBATO POLIOXIETILENADO, Y 0.01-0.08 G DE UN AGENTE CONSERVANTE ELEGIDO ENTRE P-HIDROXIBENZOATO DE METILO, P-HIDROXIBENZOATO DE ETILO Y P-HIDROXIBENZOATO DE PROPILO. TIENE UTILIDAD PARA EL TRATAMIENTO TOPICO DE LA OTITIS, ESPECIALMENTE DE LA OTITIS MEDIA ACOMPAÑADA DE PROCESO INFLAMATORIO GENERAL. CONLLEVA LA VENTAJA DE QUE SE PUEDE APLICAR A NIÑOS, Y DE QUE NO PRESENTA EL RIESGO DE OTOTOXICIDAD EN CASOS DE PERFORACION DEL TIMPANO, ASOCIADO A OTRAS COMBINACIONES DE ANTIBIOTICOS Y ANTIINFLAMATORIOS QUE SE USAN POR VIA TOPICA.ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION INCLUDES: 0.1-0.4 G OF CIPROFLOXACINO, 0.2-1.5 G OF HYDROCORTISONE, 0.3-0.8 G OF LACTIC ACID AT 20%; 0.3-0.6 G OF HYDROCHLORIC ACID 1M, 1-3 G OF GLUCOSE, 1-3 G OF A VISCOSIZANT (PREFERABLY POLYVINYLPYROLIDONE), 30-60 G OF A CO-SOLVENT (PREFERABLY PROPYLENE GLYCOL, POLYETHYLENE GLYCOL), 1-3 G OF POLYETHYLENE GLYCOL, AND 0.01-0.08 G OF A PRESERVING AGENT CHOSEN BETWEEN METHYL P-HYDROXYBENZOATE, ETHYL P-HYDROXYBENZOATE AND PROPYL P-HYDROXYBENZOATE. IT IS USEFUL FOR THE TOPICAL TREATMENT OF OTITIS, ESPECIALLY OF OTITIS MEDIA ACCOMPANIED BY A GENERAL INFLAMMATORY PROCESS. IT HAS THE ADVANTAGE THAT IT CAN BE APPLIED TO CHILDREN, AND THAT IT DOES NOT PRESENT THE RISK OF OTOTOXICITY IN CASES OF PERFORATION OF TIMPANO, ASSOCIATED WITH OTHER COMBINATIONS OF ANTIBIOTICS AND ANTI-INFLAMMATORIES USED BY VIA TOPICA.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501567A ES2105971B1 (en) | 1995-08-02 | 1995-08-02 | ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9501567A ES2105971B1 (en) | 1995-08-02 | 1995-08-02 | ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2105971A1 ES2105971A1 (en) | 1997-10-16 |
ES2105971B1 true ES2105971B1 (en) | 1998-07-01 |
Family
ID=8291261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9501567A Expired - Lifetime ES2105971B1 (en) | 1995-08-02 | 1995-08-02 | ANTIBIOTIC / ANTI-INFLAMMATORY COMPOSITION OF OTIC APPLICATION. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2105971B1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2160090B1 (en) * | 2000-03-16 | 2002-07-01 | Vita Invest Sa | Set of aqueous cyprofloxacin otitis pharmaceuticals comprises single dose products treating perforated eardrums by dropwise administration |
ES2171147B1 (en) * | 2001-02-06 | 2003-12-16 | Esteve Labor Dr | PREPARATION FOR VETERINARY USES. |
ES2245611B1 (en) * | 2004-06-29 | 2007-03-16 | Laboratorio Reig Jofre, S.A. | PHARMACEUTICAL COMPOSITION FOR OTOTOPIC USE. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3704907A1 (en) * | 1987-02-17 | 1988-08-25 | Bayer Ag | TOPICALLY APPLICABLE PREPARATIONS OF GYRASE INHIBITORS IN COMBINATION WITH CORTICOSTEROIDS |
AU4201189A (en) * | 1988-08-26 | 1990-03-23 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
ES2065846B1 (en) * | 1993-04-20 | 1995-10-01 | Cusi Lab | PHARMACEUTICAL FORMULATION BASED ON A STEROID OR NON-STEROID ANTI-INFLAMMATORY AGENT AND AN ANTIBIOTIC BELONGING TO THE GIRASE DNA INHIBITORS GROUP FOR ITS TOPICAL OPHTHALMIC USE. |
-
1995
- 1995-08-02 ES ES9501567A patent/ES2105971B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2105971A1 (en) | 1997-10-16 |
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