ES2103221B1 - NEW DERIVATIVES OF BENCIMIDAZOLE-2-TIONA, ITS PREPARATION AND ITS APPLICATION AS MEDICINES. - Google Patents

NEW DERIVATIVES OF BENCIMIDAZOLE-2-TIONA, ITS PREPARATION AND ITS APPLICATION AS MEDICINES.

Info

Publication number
ES2103221B1
ES2103221B1 ES9301754A ES9301754A ES2103221B1 ES 2103221 B1 ES2103221 B1 ES 2103221B1 ES 9301754 A ES9301754 A ES 9301754A ES 9301754 A ES9301754 A ES 9301754A ES 2103221 B1 ES2103221 B1 ES 2103221B1
Authority
ES
Spain
Prior art keywords
bencimidazole
tiona
medicines
preparation
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9301754A
Other languages
Spanish (es)
Other versions
ES2103221A1 (en
Inventor
Vidal Ramon Merce
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2103221A1 publication Critical patent/ES2103221A1/en
Application granted granted Critical
Publication of ES2103221B1 publication Critical patent/ES2103221B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

NUEVOS DERIVADOS DE BENCIMIDAZOL-2-TIONA, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS. LA PRESENTE INVENCION CONCIERNE A COMPUESTOS HETEROCICLICOS CARACTERIZADOS POR EL HECHO DE QUE RESPONDEN A LA FORMULA GENERAL (I), EN LA CUAL, R REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALQUILO LINEAL O RAMIFICADO EN C1-4, PREFERENTEMENTE ETILO E ISOPROPILO, Z REPRESENTA UN ATOMO DE NITROGENO O DE OXIGENO E Y UN GRUPO DE ENTRE LOS FRAGMENTOS (A) Y (B), Y CONCIERNE A SUS TAUTOMEROS Y A SUS SALES DE ADICION DE LOS ACIDOS FARMACEUTICAMENTE ACEPTABLES.NEW DERIVATIVES OF BENCIMIDAZOLE-2-TIONA, ITS PREPARATION AND ITS APPLICATION AS MEDICINES. THE PRESENT INVENTION CONCERNS HETERO-CYCLE COMPOUNDS CHARACTERIZED BY THE FACT THAT THEY RESPOND TO THE GENERAL FORMULA (I), IN WHICH, R REPRESENTS AN ATOMO OF HYDROGEN OR A LINEAR OR BRANCHED ALKYL IN C1-4, ETHYL EOPHY ISOPHYL AND IT REPRESENTS AN ATOM OF NITROGEN OR OXYGEN E AND A GROUP OF BETWEEN FRAGMENTS (A) AND (B), AND CONCERNS ITS TAUTOMEROS AND THEIR ADDITIONAL SALTS OF PHARMACEUTICALLY ACCEPTABLE ACIDS.

ES9301754A 1992-07-29 1993-07-28 NEW DERIVATIVES OF BENCIMIDAZOLE-2-TIONA, ITS PREPARATION AND ITS APPLICATION AS MEDICINES. Expired - Fee Related ES2103221B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9209382A FR2694292B1 (en) 1992-07-29 1992-07-29 Benzimidazole-2-thione- derivatives, their preparation and their use as medicaments.

Publications (2)

Publication Number Publication Date
ES2103221A1 ES2103221A1 (en) 1997-09-01
ES2103221B1 true ES2103221B1 (en) 1998-07-01

Family

ID=9432404

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301754A Expired - Fee Related ES2103221B1 (en) 1992-07-29 1993-07-28 NEW DERIVATIVES OF BENCIMIDAZOLE-2-TIONA, ITS PREPARATION AND ITS APPLICATION AS MEDICINES.

Country Status (2)

Country Link
ES (1) ES2103221B1 (en)
FR (1) FR2694292B1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
GEP20094638B (en) 2004-06-15 2009-03-10 Pfizer Benzimidazolone carboxylic acid derivatives
EA012615B1 (en) 2005-02-22 2009-10-30 Пфайзер Инк. Oxyindole derivatives as 5htreceptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687980T2 (en) * 1986-01-07 1993-06-17 Beecham Group Plc INDOLDER DERIVATIVES WITH AN AZABICYCLIC SIDE CHAIN, METHOD FOR THEIR PRODUCTION, INTERMEDIATE PRODUCTS AND PHARMACEUTICAL COMPOSITIONS.
IT1231413B (en) * 1987-09-23 1991-12-04 Angeli Inst Spa BENZIMIDAZOLIN-2-BONE-1-CARBOXYLIC ACID DERIVATIVES USEFUL AS 5-HT RECEPTOR ANTAGONISTS

Also Published As

Publication number Publication date
FR2694292B1 (en) 1994-10-21
ES2103221A1 (en) 1997-09-01
FR2694292A1 (en) 1994-02-04

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