ES2102829T3 - Proceso quimico. - Google Patents

Proceso quimico.

Info

Publication number
ES2102829T3
ES2102829T3 ES94906331T ES94906331T ES2102829T3 ES 2102829 T3 ES2102829 T3 ES 2102829T3 ES 94906331 T ES94906331 T ES 94906331T ES 94906331 T ES94906331 T ES 94906331T ES 2102829 T3 ES2102829 T3 ES 2102829T3
Authority
ES
Spain
Prior art keywords
formula
pct
image
compound
tetrahydronaphthalene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906331T
Other languages
English (en)
Inventor
Andrew John Blacker
Stephen Martin Brown
Derek Raymond Boyd
Gary Neil Sheldrake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2102829T3 publication Critical patent/ES2102829T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/27—Preparation of carboxylic acid esters from ortho-esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Epoxy Resins (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE (1S,2R)-1,2-EPOXI-1,2,3,4TETRAHIDRONAFTALENO QUE TIENE LA FORMULA (I), QUE COMPRENDE LOS PASOS DE (A) HIDROGENAR EL COMPUESTO DE FORMULA (II) PARA FORMAR CIS-(1R,2S)-1,2-DIHIDROXI-1,2,3,4-TETRAHIDRONAFTALENO QUE TIENE LA FORMULA (V); (B) REACCIONAR EL COMPUESTO DE DIHIDROXI DE FORMULA (V) CON UN HALURO DE SULFONILO DE FORMULA R{SUP,1}SO{SUB, 2}Z EN DONDE R{SUP,1} ES METILO, ETILO, TRIFLUOMETILO, FENILO O P-TOLILO, Y Z ES FLUOR, CLORO, BROMO O IODO PARA DAR UN ESTER BIS-SULFONILO DE FORMULA (X); Y (C) TRATAR EL ESTER BIS-SULFONILO (X) CON UN CARBONATO DE METAL ALKALI O UN HIDROXIDO DE METAL ALKALI PARA DAR EL COMPUESTO DE FORMULA (I). TAMBIEN SE PROPONE UN PROCESO PARA LA PREPARACION DE (1S,2R)-1,2-EPOXI-1,2,3,4TETRAHIDRONAFTALENO ENANTIOMERICO COMO SON NUEVOS INTERMEDIARIOS FORMADOS EN LOS PROCESOS. LOS COMPUESTOS SON UTILES COMO INTERMEDIARIOS EN LA PREPARACION DE COMPUESTOS BIOLOGICAMENTE ACTIVOS COMO PRODUCTOS FARMACEUTICOS.
ES94906331T 1993-02-26 1994-02-16 Proceso quimico. Expired - Lifetime ES2102829T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939303911A GB9303911D0 (en) 1993-02-26 1993-02-26 Chemical process

Publications (1)

Publication Number Publication Date
ES2102829T3 true ES2102829T3 (es) 1997-08-01

Family

ID=10731085

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906331T Expired - Lifetime ES2102829T3 (es) 1993-02-26 1994-02-16 Proceso quimico.

Country Status (11)

Country Link
US (1) US5637738A (es)
EP (1) EP0686153B1 (es)
JP (1) JPH08506827A (es)
AT (1) ATE154019T1 (es)
CA (1) CA2155306A1 (es)
DE (1) DE69403637T2 (es)
DK (1) DK0686153T3 (es)
ES (1) ES2102829T3 (es)
GB (1) GB9303911D0 (es)
NO (1) NO953359D0 (es)
WO (1) WO1994019338A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE410419T1 (de) * 2002-11-12 2008-10-15 Mallinckrodt Inc Cannabinoid kristalline derivate und verfahren zur reinigung von cannabinoiden
WO2011146610A2 (en) * 2010-05-19 2011-11-24 Dr. Reddy's Laboratories Ltd. An enantioselective synthesis of chiral amines for the production of rotigotine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4082773A (en) * 1972-07-03 1978-04-04 E. R. Squibb & Sons, Inc. Tricyclic tetrahydro naphthaleneols and related compounds
DE2603589C3 (de) * 1976-01-30 1978-09-28 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Alkyldisulfonsäurediphenylesterdisulfonaten
FR2627491B1 (fr) * 1988-02-18 1992-01-24 Roussel Uclaf Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant

Also Published As

Publication number Publication date
GB9303911D0 (en) 1993-04-14
ATE154019T1 (de) 1997-06-15
US5637738A (en) 1997-06-10
DE69403637D1 (de) 1997-07-10
JPH08506827A (ja) 1996-07-23
EP0686153A1 (en) 1995-12-13
NO953359L (no) 1995-08-25
EP0686153B1 (en) 1997-06-04
CA2155306A1 (en) 1994-09-01
NO953359D0 (no) 1995-08-25
WO1994019338A1 (en) 1994-09-01
DK0686153T3 (da) 1997-12-22
DE69403637T2 (de) 1997-09-18

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