ES2101654A1 - Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometil-fenoxi) propilamina. - Google Patents

Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometil-fenoxi) propilamina.

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Publication number
ES2101654A1
ES2101654A1 ES09501492A ES9501492A ES2101654A1 ES 2101654 A1 ES2101654 A1 ES 2101654A1 ES 09501492 A ES09501492 A ES 09501492A ES 9501492 A ES9501492 A ES 9501492A ES 2101654 A1 ES2101654 A1 ES 2101654A1
Authority
ES
Spain
Prior art keywords
phenyl
propylamine
methyl
trifluoromethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09501492A
Other languages
English (en)
Other versions
ES2101654B1 (es
Inventor
Jesus Ezquerra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly SA
Original Assignee
Lilly SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly SA filed Critical Lilly SA
Priority to ES9501492A priority Critical patent/ES2101654B1/es
Publication of ES2101654A1 publication Critical patent/ES2101654A1/es
Application granted granted Critical
Publication of ES2101654B1 publication Critical patent/ES2101654B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE N-METIL-3-FENIL-3-(P-TRIFLUOROMETILFENOXI)PROPILAMINA. CONSTA DE LAS SIGUIENTES ETAPAS: A) TRANSFORMAR CIANOMETIL FENIL CETONA EN 3-FENIL-3-HIDROXIPROPANONITRILO MEDIANTE REDUCCION CON BOROHIDRURO SODICO EN TETRAHIDROFURANO; B) TRANSFORMAR 3-FENIL-3-HIDROXIPROPANONITRILO EN 3-FENIL-3-HIDROXIPROPANAMINA MEDIANTE TRATAMIENTO CON EL COMPLEJO BORANO-SULFURO DE DIMETILO; GENERAR EL ALCOXIDO SODICO DE 3-FENIL-3-HIDROXIPROPANAMINA CON HIDRURO SODICO EN DIMETILSULFOXIDO, Y HACERLO REACCIONAR CVAIN SITU CON 1-CLORO-4-(TRIFLUOROMETIL)-BENCENO; HACER REACCIONAR EL 3-FENIL-3-(P-TRIFLUOROMETILFENOXI)PROPILAMINA ASI OBTENIDO, O SU HDIROCLORURO, CON CLOROFORMIATO DE METILO, FORMANDO EL CORRESPONDIENTE CARBAMATO; TRANSFORMAR CVAIN SITU DICHO CARBAMATO; EN EL PRODUCTO N-METIL-3-FENIL-3-(P-TRIFLUOROMETILFENOXI)PROPILAMINA (I) DESEADO, MEDIANTE REDUCCION CON HIDRURO DE ALUMINIO Y LITIO EN TETRAHIDROFURANO. LA INVENCION TIENE UTILIDAD PARA LA PREPARACION INDUSTRIALMENTE VENTAJOSA DE (I).
ES9501492A 1995-07-24 1995-07-24 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina. Expired - Fee Related ES2101654B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9501492A ES2101654B1 (es) 1995-07-24 1995-07-24 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9501492A ES2101654B1 (es) 1995-07-24 1995-07-24 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.

Publications (2)

Publication Number Publication Date
ES2101654A1 true ES2101654A1 (es) 1997-07-01
ES2101654B1 ES2101654B1 (es) 1998-01-16

Family

ID=8291152

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9501492A Expired - Fee Related ES2101654B1 (es) 1995-07-24 1995-07-24 Procedimiento de preparacion de n-metil-3-fenil-3-(p-trifluorometilfe noxi) propilamina.

Country Status (1)

Country Link
ES (1) ES2101654B1 (es)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES433720A1 (es) * 1974-01-10 1976-12-01 Lilly Co Eli Un procedimiento para preparar los compuestos 3-ariloxi-3- fenilpropilamina.
ES8707175A1 (es) * 1986-06-13 1987-07-16 Inke Sa Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina
EP0369685A2 (en) * 1988-11-14 1990-05-23 Eli Lilly And Company Fluoxetine analog
EP0380924A1 (en) * 1989-01-10 1990-08-08 Grato Magnone Process for the preparation of fluoxetine hydrochloride
EP0391070A1 (en) * 1989-03-03 1990-10-10 Orion-Yhtymä Oy Fermion Process for the preparation of N-methyl-3-(p-trifluoro-methylphenoxy)-3-phenyl-propylamine and their salts
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES433720A1 (es) * 1974-01-10 1976-12-01 Lilly Co Eli Un procedimiento para preparar los compuestos 3-ariloxi-3- fenilpropilamina.
ES8707175A1 (es) * 1986-06-13 1987-07-16 Inke Sa Procedimiento para la obtencion de la n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina
EP0369685A2 (en) * 1988-11-14 1990-05-23 Eli Lilly And Company Fluoxetine analog
EP0380924A1 (en) * 1989-01-10 1990-08-08 Grato Magnone Process for the preparation of fluoxetine hydrochloride
EP0391070A1 (en) * 1989-03-03 1990-10-10 Orion-Yhtymä Oy Fermion Process for the preparation of N-methyl-3-(p-trifluoro-methylphenoxy)-3-phenyl-propylamine and their salts
WO1994000416A1 (en) * 1992-06-26 1994-01-06 Richter Gedeon Vegyészeti Gyár Rt. Preparation of n-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine and acid addition salts thereof

Also Published As

Publication number Publication date
ES2101654B1 (es) 1998-01-16

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