ES2100109A1 - Inhibidores de proteasas de aminodiol. - Google Patents

Inhibidores de proteasas de aminodiol.

Info

Publication number
ES2100109A1
ES2100109A1 ES09301578A ES9301578A ES2100109A1 ES 2100109 A1 ES2100109 A1 ES 2100109A1 ES 09301578 A ES09301578 A ES 09301578A ES 9301578 A ES9301578 A ES 9301578A ES 2100109 A1 ES2100109 A1 ES 2100109A1
Authority
ES
Spain
Prior art keywords
aminodiol
protease inhibitors
protease
hiv
aids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301578A
Other languages
English (en)
Other versions
ES2100109B1 (es
Inventor
Eric M Gordon
Joel C Barrish
Gregory S Bisacchi
Chong-Qing Sun
Joseph A Tino
Gregory D Vite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to ES9301578A priority Critical patent/ES2100109B1/es
Publication of ES2100109A1 publication Critical patent/ES2100109A1/es
Application granted granted Critical
Publication of ES2100109B1 publication Critical patent/ES2100109B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

INHIBIDORES DE PROTEASAS DE AMINODIOL, QUE TIENEN LA FORMULAFORMULA DONDE LOS SIMBOLOS AA, AB, AC, DA, DB, R1 Y R2 TIENEN LOS SIGNIFICADOS INDICADOS EN LA MEMORIA DESCRIPTIVA. ESTOS COMPUESTOS SON UTILES EN LA INHIBICION DE PROTEASA RETROVIRAL Y EN EL TRATAMIENTO Y/O LA PREVENCION DE LA INFECCION POR VIH (SIDA).
ES9301578A 1993-07-14 1993-07-14 Inhibidores de proteasas de aminodiol. Expired - Fee Related ES2100109B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301578A ES2100109B1 (es) 1993-07-14 1993-07-14 Inhibidores de proteasas de aminodiol.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301578A ES2100109B1 (es) 1993-07-14 1993-07-14 Inhibidores de proteasas de aminodiol.

Publications (2)

Publication Number Publication Date
ES2100109A1 true ES2100109A1 (es) 1997-06-01
ES2100109B1 ES2100109B1 (es) 1998-02-16

Family

ID=8282547

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301578A Expired - Fee Related ES2100109B1 (es) 1993-07-14 1993-07-14 Inhibidores de proteasas de aminodiol.

Country Status (1)

Country Link
ES (1) ES2100109B1 (es)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2046720A (en) * 1933-06-09 1936-07-07 Girdler Corp Nu-hydroxy-aminoalkyl substituted alkylene diamines
US2716631A (en) * 1951-11-03 1955-08-30 Hercules Powder Co Ltd Nitric acid concentration
EP0229667A2 (en) * 1986-01-16 1987-07-22 Abbott Laboratories Peptidylaminodiols
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0356223A2 (en) * 1988-08-24 1990-02-28 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0357332A2 (en) * 1988-08-24 1990-03-07 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of HIV protease
EP0402646A1 (en) * 1989-05-23 1990-12-19 Abbott Laboratories Retroviral protease inhibiting compounds
EP0410260A2 (en) * 1989-07-26 1991-01-30 Abbott Laboratories Peptidyl aminodiol renin inhibitors
EP0416373A2 (de) * 1989-09-04 1991-03-13 F. Hoffmann-La Roche Ag Aminosäurederivate
EP0492136A2 (en) * 1990-12-20 1992-07-01 American Cyanamid Company Retroviral protease inhibitors derived from 3-chloro-2-chloromethyl-1-propene

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2046720A (en) * 1933-06-09 1936-07-07 Girdler Corp Nu-hydroxy-aminoalkyl substituted alkylene diamines
US2716631A (en) * 1951-11-03 1955-08-30 Hercules Powder Co Ltd Nitric acid concentration
EP0229667A2 (en) * 1986-01-16 1987-07-22 Abbott Laboratories Peptidylaminodiols
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0356223A2 (en) * 1988-08-24 1990-02-28 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0357332A2 (en) * 1988-08-24 1990-03-07 Merck & Co. Inc. Renin inhibitors useful for the treatment of aids by inhibition of HIV protease
EP0402646A1 (en) * 1989-05-23 1990-12-19 Abbott Laboratories Retroviral protease inhibiting compounds
EP0410260A2 (en) * 1989-07-26 1991-01-30 Abbott Laboratories Peptidyl aminodiol renin inhibitors
EP0416373A2 (de) * 1989-09-04 1991-03-13 F. Hoffmann-La Roche Ag Aminosäurederivate
EP0492136A2 (en) * 1990-12-20 1992-07-01 American Cyanamid Company Retroviral protease inhibitors derived from 3-chloro-2-chloromethyl-1-propene

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BARRISH, J.C. et al.: "Aminodiol HIV protease Inhibitors. 1. Design, Synthesis, and preliminary SAR" J. MED. CHEM., Vol. 37, 1994, WASHINGTON, pßginas 1758-1768 *
EDS. L. KAUDY, J.F. ROUNSAVILLE, G. SCHULZ: "Ullman's Encyclopedia of Industrial Chemistry, 5th. Ed." 1987, VCH, WEINHEIM, pßginas 531-545 *
ERICKSON, J. et al.: "Design, Activity and 2,8 A Crystal Structure of a C2 Symmetric Inhibitor Complexed to HIV-1 Protease" SCIENCE, Vol. 249, 3 Agosto 1990, WASHINGTON, pßginas 527-533 * Todo el documento * *
GORDON, E.M. et al.: "Design of Peptide Derived Amino Alcohols as Transition-State Analog Inhibitors of Angiotensin Converting Enzyme" BIOCHEM. BIOPHYS. RES. COMMUN., Vol. 126, n‘ 1, 1985, pßginas 419-426 *
J. MARCH: "Advanced Organic Chemistry" 1985, J. WILEY & SONS, NEW YORK, Pßginas 270,664,726,727 *
KEMPF, D.J. y col. "Structure-based C2 Symetric Inhibitors of HIV Protease" J. MED. CHEM., Vol. 33, 1990, WASHINGTON, pßginas 2687-2690 *
MARTIN, J.A.: "Recent advances in the deign of HIV protease inhibitors" ANTIVIRAL RES., Vol. 17, 1992, pßginas 265-278 * Todo el documento * *
RICHARDS, A.D. et al.: "Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases" FEBS LETTERS, Vol. 247, Abril 1989, pßginas 113-117 * Todo el documento * *
YOUNG, S.D. et al.: "HIV-1 Protease Inhibitors Based on Hydroxyethylene Dipeptide Isosteres: An Investigation into the Role of P1' Side Chain on Structure-Activity" J. MED. CHEM., Vol. 35, 1992, WASHINGTON, pßginas 1702-1709 * Todo el documento * *

Also Published As

Publication number Publication date
ES2100109B1 (es) 1998-02-16

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