ES2099344T3 - FLUPIRTIN AND MORPHINE BASED COMBINATION PREPARATION FOR PAIN TREATMENT AND TO PREVENT ADDICTION TO MORPHINE. - Google Patents
FLUPIRTIN AND MORPHINE BASED COMBINATION PREPARATION FOR PAIN TREATMENT AND TO PREVENT ADDICTION TO MORPHINE.Info
- Publication number
- ES2099344T3 ES2099344T3 ES93117472T ES93117472T ES2099344T3 ES 2099344 T3 ES2099344 T3 ES 2099344T3 ES 93117472 T ES93117472 T ES 93117472T ES 93117472 T ES93117472 T ES 93117472T ES 2099344 T3 ES2099344 T3 ES 2099344T3
- Authority
- ES
- Spain
- Prior art keywords
- morphine
- flupirtin
- combination preparation
- pain treatment
- based combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The combination of flupirtine and morphine has the property of potent analgesic activity and not generating any morphine-like dependence and tolerance. Novel pharmaceutical compositions containing this combination of active substances are described.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4236752A DE4236752A1 (en) | 1992-10-30 | 1992-10-30 | Combination preparation of flupirtine and morphine for the treatment of pain and for avoiding morphine addiction |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2099344T3 true ES2099344T3 (en) | 1997-05-16 |
Family
ID=6471783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93117472T Expired - Lifetime ES2099344T3 (en) | 1992-10-30 | 1993-10-28 | FLUPIRTIN AND MORPHINE BASED COMBINATION PREPARATION FOR PAIN TREATMENT AND TO PREVENT ADDICTION TO MORPHINE. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5521178A (en) |
EP (1) | EP0595311B1 (en) |
JP (1) | JP3665354B2 (en) |
AT (1) | ATE147979T1 (en) |
BR (1) | BR9304431A (en) |
CA (1) | CA2102072C (en) |
DE (2) | DE4236752A1 (en) |
DK (1) | DK0595311T3 (en) |
ES (1) | ES2099344T3 (en) |
GR (1) | GR3022995T3 (en) |
HU (1) | HU219907B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL119660A (en) * | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (en) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | Manufacturing method and sustained release composition of pharmaceutical composition |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
DE19918325A1 (en) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Extruded drug dosage form, e.g. granulate for tableting, comprising an active agent in a polysaccharide-containing matrix, giving a release profile which is controllable by extrusion conditions and/or the inclusion of additives |
CN1399550A (en) * | 1999-08-03 | 2003-02-26 | Awd药品股份有限两合公司 | Use of flupirtine for alleviating pain caused by degenerative joint diseases in dogs and cats |
AU2004298288B2 (en) * | 2003-12-16 | 2011-06-30 | Relevare Aust. Pty Ltd | Methods and compositions |
US8334263B2 (en) * | 2003-12-16 | 2012-12-18 | Raymond Nadeson | Analgesic methods and compositions |
US7553858B2 (en) * | 2003-12-17 | 2009-06-30 | Meda Pharma Gmbh & Co. Kg | Combination of flupirtine and tramadol |
US20060052370A1 (en) * | 2004-08-24 | 2006-03-09 | Meyerson Laurence R | Methods and compositions for treating nociceptive pain |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
EP1688141A1 (en) | 2005-01-31 | 2006-08-09 | elbion AG | The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome |
RU2007140348A (en) * | 2005-04-06 | 2009-05-20 | Адамас Фармасьютикалс, Инк. (Us) | METHODS AND COMPOSITIONS FOR TREATMENT OF CNS DISEASES |
US20070042054A1 (en) * | 2005-04-20 | 2007-02-22 | Council Of Scientific And Industrial Research | Functional aphrodisiac rolled herbal bidis and cigarettes |
RU2454437C2 (en) * | 2006-11-28 | 2012-06-27 | ПУРАК Биокем БВ | Stable lactide particles |
US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
CA2751037A1 (en) * | 2009-01-30 | 2010-08-05 | Relevare Aust. Pty Ltd. | Drug abuse deterrent, methods and compositions |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI855016A (en) * | 1985-06-28 | 1986-12-29 | Degussa | SYNERGISTIC COMBINATION AV FLUPIRTIN OCH 4-ACETAMIDO-PHENOL. |
-
1992
- 1992-10-30 DE DE4236752A patent/DE4236752A1/en not_active Withdrawn
-
1993
- 1993-10-27 US US08/141,678 patent/US5521178A/en not_active Expired - Lifetime
- 1993-10-28 DK DK93117472.6T patent/DK0595311T3/en active
- 1993-10-28 ES ES93117472T patent/ES2099344T3/en not_active Expired - Lifetime
- 1993-10-28 DE DE59305236T patent/DE59305236D1/en not_active Expired - Lifetime
- 1993-10-28 EP EP93117472A patent/EP0595311B1/en not_active Expired - Lifetime
- 1993-10-28 AT AT93117472T patent/ATE147979T1/en active
- 1993-10-29 BR BR9304431A patent/BR9304431A/en not_active Application Discontinuation
- 1993-10-29 HU HU9303089A patent/HU219907B/en unknown
- 1993-10-29 CA CA002102072A patent/CA2102072C/en not_active Expired - Lifetime
- 1993-10-29 JP JP27173093A patent/JP3665354B2/en not_active Expired - Lifetime
-
1997
- 1997-04-01 GR GR970400669T patent/GR3022995T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06211663A (en) | 1994-08-02 |
GR3022995T3 (en) | 1997-07-30 |
DE59305236D1 (en) | 1997-03-06 |
EP0595311B1 (en) | 1997-01-22 |
ATE147979T1 (en) | 1997-02-15 |
US5521178A (en) | 1996-05-28 |
JP3665354B2 (en) | 2005-06-29 |
BR9304431A (en) | 1994-06-07 |
EP0595311A1 (en) | 1994-05-04 |
DE4236752A1 (en) | 1994-05-05 |
HU9303089D0 (en) | 1994-01-28 |
HUT66085A (en) | 1994-09-28 |
DK0595311T3 (en) | 1997-05-26 |
CA2102072A1 (en) | 1994-05-01 |
HU219907B (en) | 2001-09-28 |
CA2102072C (en) | 2005-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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