ES2097822T3 - Nuevos derivados de piridina, su procedimiento de produccion y su utilizacion como medicamentos. - Google Patents

Nuevos derivados de piridina, su procedimiento de produccion y su utilizacion como medicamentos.

Info

Publication number
ES2097822T3
ES2097822T3 ES91920436T ES91920436T ES2097822T3 ES 2097822 T3 ES2097822 T3 ES 2097822T3 ES 91920436 T ES91920436 T ES 91920436T ES 91920436 T ES91920436 T ES 91920436T ES 2097822 T3 ES2097822 T3 ES 2097822T3
Authority
ES
Spain
Prior art keywords
alkyl
pct
valency bond
date jun
tetrazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91920436T
Other languages
English (en)
Inventor
Walter-Gunar Friebe
Wolfgang Kampe
Marcel Linssen
Otto-Henning Wilhelms
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2097822T3 publication Critical patent/ES2097822T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

COMPUESTOS DE FORMULA (I), EN LA CUAL A ES UN RESTO ALQUILENO CON 1 A 3 ATOMOS DE CARBONO, O UN GRUPO UN ATOMO DE OXIGENO O UN ENLACE DE VALENCIA, M ES UNA CIFRA ENTERA DE 0 A 5, N ES LA CIFRA 0 O 1, X ES UN ENLACE DE VALENCIA, UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE, Y ES UN ENLACE DE VALENCIA O UN RESTO FENILENO, OPCIONALMENTE SUSTITUIDO UNA O VARIAS VECES POR C1 HIDROXI O AMINOCARBONILO, Z ES HIDROGENO, HALOGENO, C1 ALQUILO O CIANO, Y R ES UN GRUPO CN, COOH, COOC1 O, CONH TETRAZOLILO, CON(OH)(C1 ETRAZOLILO, ASI COMO SI Y ES UN RESTO FENILENO, R PUEDE SIGNIFICAR TAMBIEN HIDROGENO, CON LA EXCEPCION DEL COMPUESTO 4 ES FISIOLOGICAMENTE Y PROCEDIMIENTO PARA SU OBTENCION, ASI COMO LOS MEDICAMENTOS QUE CONTIENEN ESTOS COMPUESTOS, PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS.
ES91920436T 1990-12-01 1991-11-28 Nuevos derivados de piridina, su procedimiento de produccion y su utilizacion como medicamentos. Expired - Lifetime ES2097822T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4038335A DE4038335A1 (de) 1990-12-01 1990-12-01 Neue pyridinderivate, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2097822T3 true ES2097822T3 (es) 1997-04-16

Family

ID=6419357

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91920436T Expired - Lifetime ES2097822T3 (es) 1990-12-01 1991-11-28 Nuevos derivados de piridina, su procedimiento de produccion y su utilizacion como medicamentos.

Country Status (9)

Country Link
US (1) US5399575A (es)
EP (1) EP0559695B1 (es)
JP (1) JPH06503076A (es)
AT (1) ATE148115T1 (es)
AU (1) AU8957491A (es)
CA (1) CA2099603A1 (es)
DE (2) DE4038335A1 (es)
ES (1) ES2097822T3 (es)
WO (1) WO1992009598A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852041A (en) * 1993-04-07 1998-12-22 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acethylcholine receptors
US5567710A (en) * 1994-10-13 1996-10-22 Sibia Neurosciences, Inc. Polycyclic fused ring modulators of acetylcholine receptors
US5677459A (en) * 1994-11-10 1997-10-14 Sibia Neurosciences, Inc. Methods for the preparation of modulators of acetylcholine receptors
US5703100A (en) * 1994-11-10 1997-12-30 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5705512A (en) * 1994-11-10 1998-01-06 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5723477A (en) * 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5594011A (en) * 1994-11-10 1997-01-14 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US6194581B1 (en) 1995-04-07 2001-02-27 Merck & Co., Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5794887A (en) 1995-11-17 1998-08-18 Komerath; Narayanan M. Stagnation point vortex controller
US6489357B1 (en) 1998-06-04 2002-12-03 University Of Puerto Rico Tobacco cembranoids block the expression of the behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptors
WO2000038676A1 (en) * 1998-12-23 2000-07-06 Novartis Ag Use of at-1 receptor antagonist or at-2 receptor modulator for treating diseases associated with an increase of at-1 or at-2 receptors
HUP0500069A2 (hu) * 2002-02-20 2005-04-28 Saint-Gobain Glass France Merev elemmel, adott esetben egy ráformázott műanyag részben befoglalt merev elemmel ellátott üvegezés
GB0214149D0 (en) * 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
WO2006078941A2 (en) * 2005-01-20 2006-07-27 Sirtris Pharmaceuticals, Inc. Novel sirtuin activating compounds and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1134828A (en) * 1978-12-28 1982-11-02 Tadao Tanouchi Pyridine derivatives
DE3641024A1 (de) * 1986-12-01 1988-06-16 Merck Patent Gmbh Stickstoffhaltige sechsringverbindungen
US5004743A (en) * 1987-11-25 1991-04-02 Merck Frosst Canada, Inc. Pyridyl styrene dialkanoic acids as anti-leukotriene agents
IT1228893B (it) * 1989-02-24 1991-07-09 Valeas Spa Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche

Also Published As

Publication number Publication date
EP0559695B1 (de) 1997-01-22
EP0559695A1 (en) 1993-09-15
DE59108513D1 (de) 1997-03-06
US5399575A (en) 1995-03-21
JPH06503076A (ja) 1994-04-07
AU8957491A (en) 1992-06-25
DE4038335A1 (de) 1992-06-04
CA2099603A1 (en) 1992-06-02
WO1992009598A1 (de) 1992-06-11
ATE148115T1 (de) 1997-02-15

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