ES2094843T3 - BENCISOTIAZOL- AND BENCISOXAZOL-3-CARBOXAMIDES, A PROCEDURE FOR THEIR PREPARATION AND USE AS ANTIPSYCHOTIC MEDICINES. - Google Patents

BENCISOTIAZOL- AND BENCISOXAZOL-3-CARBOXAMIDES, A PROCEDURE FOR THEIR PREPARATION AND USE AS ANTIPSYCHOTIC MEDICINES.

Info

Publication number
ES2094843T3
ES2094843T3 ES92107138T ES92107138T ES2094843T3 ES 2094843 T3 ES2094843 T3 ES 2094843T3 ES 92107138 T ES92107138 T ES 92107138T ES 92107138 T ES92107138 T ES 92107138T ES 2094843 T3 ES2094843 T3 ES 2094843T3
Authority
ES
Spain
Prior art keywords
loweralkyl
hydrogen
formula
carboxamides
chr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92107138T
Other languages
Spanish (es)
Inventor
Nicholas J Hrib
John G Jurcak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ES2094843T3 publication Critical patent/ES2094843T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

The present invention relates to benzisothiazole- and benzisoxazole-3-carboxamides of the formula I <CHEM> wherein R<1> is hydrogen or loweralkyl; R<2> is loweralkyl, or a group of the formula <CHEM> R<3> is hydrogen or loweralkyl; A is loweralkylene, a group of the formula -CHR<4>CH=CHCHR<4>-, or -CHR<4>C IDENTICAL CHR<4>-; R<4> is hydrogen or loweralkyl; X is O or S; W is N or CH; Y is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; Z is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; n is 1 or 2; wherein the solid line (-) refers to the point of attachment of the group to the indicated member of the formula; the geometric and optical isomers thereof; or a pharmaceutically acceptable salt thereof, useful for the treatment of psychoses, alone or in combination with inert adjuvants.
ES92107138T 1991-04-29 1992-04-27 BENCISOTIAZOL- AND BENCISOXAZOL-3-CARBOXAMIDES, A PROCEDURE FOR THEIR PREPARATION AND USE AS ANTIPSYCHOTIC MEDICINES. Expired - Lifetime ES2094843T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90/002891A US5143923B1 (en) 1991-04-29 1991-04-29 Benzoisothiazole-and benzisoxazole-3-carboxamides

Publications (1)

Publication Number Publication Date
ES2094843T3 true ES2094843T3 (en) 1997-02-01

Family

ID=24783602

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92107138T Expired - Lifetime ES2094843T3 (en) 1991-04-29 1992-04-27 BENCISOTIAZOL- AND BENCISOXAZOL-3-CARBOXAMIDES, A PROCEDURE FOR THEIR PREPARATION AND USE AS ANTIPSYCHOTIC MEDICINES.

Country Status (21)

Country Link
US (1) US5143923B1 (en)
EP (1) EP0511610B1 (en)
JP (1) JP2656189B2 (en)
KR (1) KR100215345B1 (en)
AT (1) ATE142628T1 (en)
AU (1) AU644054B2 (en)
CA (1) CA2067404C (en)
CZ (1) CZ282764B6 (en)
DE (1) DE69213544T2 (en)
DK (1) DK0511610T3 (en)
ES (1) ES2094843T3 (en)
FI (1) FI921875A (en)
GR (1) GR3021211T3 (en)
HU (1) HU214032B (en)
IE (1) IE77036B1 (en)
IL (1) IL101700A (en)
MX (1) MX9201963A (en)
NO (1) NO180488C (en)
NZ (1) NZ242479A (en)
PL (2) PL168870B1 (en)
RU (1) RU2039057C1 (en)

Families Citing this family (32)

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US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
SE9201138D0 (en) * 1992-04-09 1992-04-09 Astra Ab NOVEL PHTHALIMIDOALKYL PIPERAZINES
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
GB9603457D0 (en) * 1996-02-19 1996-04-17 Merck & Co Inc
IL117295A (en) * 1995-02-28 1999-11-30 Lundbeck & Co As H 4-Aminotetrahydro-benzisoxazole or-isothiazole compounds and pharmaceutical compositions comprising them
DK0732332T3 (en) * 1995-03-17 2002-04-15 Aventis Pharma Inc Substituted benzothienylpiperazines, their use as drugs and their methods of preparation
GB9716101D0 (en) * 1997-07-30 1997-10-01 Pharmacia & Upjohn Spa Fused heterocyclic compounds
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
JP3475177B2 (en) * 1998-11-17 2003-12-08 エフ．ホフマン−ラ ロシュ アーゲー 4-Aroylpiperidine CCR-3 receptor antagonist III
ATE386720T1 (en) 1998-11-20 2008-03-15 Hoffmann La Roche PIPERIDINE CCR-3 RECEPTOR INHIBITORS
PL350904A1 (en) * 1999-03-26 2003-02-10 Astrazeneca Ab Novel compounds
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
RU2269523C2 (en) 2000-04-28 2006-02-10 Акадиа Фармасьютикалз, Инк. Muscarinic agonists
GB0013060D0 (en) * 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) * 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
EP1632483B1 (en) 2001-02-16 2008-10-29 Aventis Pharmaceuticals Inc. Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
GB0117899D0 (en) * 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
SE0102809D0 (en) * 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
US7605259B2 (en) * 2002-09-14 2009-10-20 University Of North Texas Health Science Center At Fort Worth Structurally rigid dopamine d3 receptor selective ligands and process for making them
JP2006503106A (en) * 2002-09-17 2006-01-26 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Heterocyclic substituted piperazine for treating schizophrenia
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
SG131946A1 (en) * 2003-10-24 2007-05-28 Hoffmann La Roche Ccr3 receptor antagonists
US20160296146A9 (en) * 2006-06-29 2016-10-13 Fred Wood Apparatus-Mounted Vein Contrast Enchancer

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US2626260A (en) * 1951-09-05 1953-01-20 Sterling Drug Inc Nitrobenzisoxazoles
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
US4021552A (en) * 1975-06-27 1977-05-03 A. H. Robins Company, Incorporated 10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES
US4327103A (en) * 1980-07-07 1982-04-27 Hoechst-Roussel Pharmaceuticals Incorporated 3-{3-[4-(4-Fluorobenzoyl)piperidyl]propyl}-2-methyl indole
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IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
NZ209876A (en) * 1983-10-17 1988-03-30 Duphar Int Res Piperazines and pharmaceutical compositions
CH667657A5 (en) * 1985-01-07 1988-10-31 Sandoz Ag CARBOCYCLIC AND HETEROCYCLIC CARBONYL METHYLENE AND METHYL PIPERIDINE AND PYRROLIDINE.
JPS61219950A (en) * 1985-03-26 1986-09-30 Fuji Photo Film Co Ltd Heat developable photosensitive material
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
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GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
FR2616149B1 (en) * 1987-06-04 1990-10-19 Adir NOVEL DERIVATIVE OF BENZO (B) THIOPHENE - 7 CARBOXYLIC ACID, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
DE3827253A1 (en) * 1987-08-20 1989-03-02 Sandoz Ag Esters and amides of cyclic carboxylic acids and cyclic alcohols and amines, processes for their preparation and therapeutic compositions containing them
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
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Also Published As

Publication number Publication date
DE69213544T2 (en) 1997-02-27
AU1518792A (en) 1992-11-05
CS129892A3 (en) 1992-11-18
IE921379A1 (en) 1992-11-04
RU2039057C1 (en) 1995-07-09
PL294358A1 (en) 1993-08-09
CA2067404A1 (en) 1992-10-30
PL168870B1 (en) 1996-04-30
NZ242479A (en) 1995-02-24
EP0511610A1 (en) 1992-11-04
HU214032B (en) 1997-12-29
FI921875A0 (en) 1992-04-27
EP0511610B1 (en) 1996-09-11
DK0511610T3 (en) 1997-06-16
ATE142628T1 (en) 1996-09-15
HUT62889A (en) 1993-06-28
AU644054B2 (en) 1993-12-02
IL101700A (en) 1995-11-27
PL168090B1 (en) 1996-01-31
US5143923B1 (en) 1993-11-02
CZ282764B6 (en) 1997-10-15
CA2067404C (en) 2003-08-19
NO921654D0 (en) 1992-04-28
JPH05132472A (en) 1993-05-28
KR100215345B1 (en) 1999-08-16
NO921654L (en) 1992-10-30
MX9201963A (en) 1992-11-01
IL101700A0 (en) 1992-12-30
JP2656189B2 (en) 1997-09-24
IE77036B1 (en) 1997-11-19
NO180488C (en) 1997-04-30
KR920019784A (en) 1992-11-20
DE69213544D1 (en) 1996-10-17
NO180488B (en) 1997-01-20
HU9201414D0 (en) 1992-07-28
US5143923A (en) 1992-09-01
FI921875A (en) 1992-10-30
GR3021211T3 (en) 1996-12-31

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