ES2088742A1 - Composicion antibiotica de aplicacion otica. - Google Patents

Composicion antibiotica de aplicacion otica.

Info

Publication number
ES2088742A1
ES2088742A1 ES09401411A ES9401411A ES2088742A1 ES 2088742 A1 ES2088742 A1 ES 2088742A1 ES 09401411 A ES09401411 A ES 09401411A ES 9401411 A ES9401411 A ES 9401411A ES 2088742 A1 ES2088742 A1 ES 2088742A1
Authority
ES
Spain
Prior art keywords
hydroxybenzoate
otitis
antibiotic preparation
acid
floxacin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09401411A
Other languages
English (en)
Other versions
ES2088742B1 (es
Inventor
Vidal Carlos Monserrat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Salvat SA
Original Assignee
Laboratorios Salvat SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Salvat SA filed Critical Laboratorios Salvat SA
Priority to ES9401411A priority Critical patent/ES2088742B1/es
Priority to EP19950500092 priority patent/EP0689832B1/en
Priority to DE1995618954 priority patent/DE69518954T2/de
Publication of ES2088742A1 publication Critical patent/ES2088742A1/es
Application granted granted Critical
Publication of ES2088742B1 publication Critical patent/ES2088742B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene

Abstract

JUNTO A LA CANTIDAD DE AGUA SUFICIENTE PARA 100 ML, COMPRENDE: 0,2-0,4 G DE CIPROFLOXACINO, 0,3-0,8 G DE ACIDO LACTICO AL 20 POR CIENTO; 0,3-0,6 G DE ACIDO CLORHIDRICO 1M, 1-4 G DE GLUCOSA; 0,04-0,08 G DE P-HIDROXIBENZOATO DE METILO; 0,02-0,04 G DE P-HIDROXIBENZOATO DE ETILO; 0,7-1,6 G DE UN DISOLVENTE SELECCIONADO ENTRE PROPILENGLICOL Y POLIETILENGLICOL; Y 1-4 G DE UN VISCOSIZANTE SELECCIONADO ENTRE POLIVINILPIRROLIDONA, HIDROXIPROPILCELULOSA, HIDROXIPROPILMETILCELULOSA, CARBOXIPOLIMETILENO Y UN POLIMERO ENTRECRUZADO DERIVADO DEL ACIDO ACRILICO. TIENE UTILIDAD PARA EL TRATAMIENTO TOPICO DE OTITIS, ESPECIALMENTE DE OTITIS MEDIA CRONICA SUPURATIVA Y DE OTITIS EXTERNA DIFUSA. CONLLEVA LAS VENTAJAS DE QUE SE PUEDE APLICAR A NIÑOS Y DE QUE NO PRESENTA EL RIESGO DE OTOTOXICIDAD, EN CASOS DE PERFORACION DEL TIMPANO, ASOCIADO A OTROS ANTIBIOTICOS USADOS POR VIA OTICA.
ES9401411A 1994-06-29 1994-06-29 Composicion antibiotica de aplicacion otica. Expired - Fee Related ES2088742B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9401411A ES2088742B1 (es) 1994-06-29 1994-06-29 Composicion antibiotica de aplicacion otica.
EP19950500092 EP0689832B1 (en) 1994-06-29 1995-06-28 Antibiotic preparation for aural application
DE1995618954 DE69518954T2 (de) 1994-06-29 1995-06-28 Antibiotische Zubereitung zur auralen Anwendung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9401411A ES2088742B1 (es) 1994-06-29 1994-06-29 Composicion antibiotica de aplicacion otica.

Publications (2)

Publication Number Publication Date
ES2088742A1 true ES2088742A1 (es) 1996-08-16
ES2088742B1 ES2088742B1 (es) 1997-03-16

Family

ID=8286730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9401411A Expired - Fee Related ES2088742B1 (es) 1994-06-29 1994-06-29 Composicion antibiotica de aplicacion otica.

Country Status (3)

Country Link
EP (1) EP0689832B1 (es)
DE (1) DE69518954T2 (es)
ES (1) ES2088742B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2160090A1 (es) * 2000-03-16 2001-10-16 Vita Invest Sa Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU708540B2 (en) * 1995-06-06 1999-08-05 Bayer Intellectual Property Gmbh Non-irritation, nonsensitizing, non-ototoxic otic anti-bacterial compositions
US5843930A (en) * 1995-06-06 1998-12-01 Bayer Corporation Method of treating otitis with ciprofloxacin-hydrocortisone suspension
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
EP1049459B1 (en) * 1998-01-20 2009-04-22 Applied Analytical Industries, Inc. Oral liquid compositions
HN1999000174A (es) * 1998-10-30 1999-10-13 Bayer Ag Formulacion medicamentosa acuisa para administracion oral.
US20040101506A1 (en) * 2002-11-25 2004-05-27 Fust Charles A. Composition for the prevention and treatment of inflammation of the ear
ZA200803367B (en) * 2005-09-26 2009-09-30 Piedmont Pharmaceuticals Llc Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067666A1 (en) * 1981-06-11 1982-12-22 Warner-Lambert Company Salts of antimicrobial naphthyridine and quinoline compounds and their production
EP0138018A2 (de) * 1983-09-17 1985-04-24 Bayer Ag Lösungen milchsaurer Salze von Piperazinylchinolon- und Piperazinyl-azachinoloncarbonsäuren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (de) 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3537761A1 (de) 1985-10-24 1987-04-30 Bayer Ag Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure
DE3632222A1 (de) * 1986-09-23 1988-04-07 Bayer Ag Topisch anwendbare zubereitungen von gyrase-inhibitoren
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
WO1990001933A1 (en) 1988-08-26 1990-03-08 Alcon Laboratories, Inc. Combination of quinolone antibiotics and steroids for topical ophthalmic use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067666A1 (en) * 1981-06-11 1982-12-22 Warner-Lambert Company Salts of antimicrobial naphthyridine and quinoline compounds and their production
EP0138018A2 (de) * 1983-09-17 1985-04-24 Bayer Ag Lösungen milchsaurer Salze von Piperazinylchinolon- und Piperazinyl-azachinoloncarbonsäuren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2160090A1 (es) * 2000-03-16 2001-10-16 Vita Invest Sa Composiciones acuosas de ciprofloxacino, contenidas en envases monodosis y su utilizacion.

Also Published As

Publication number Publication date
EP0689832A2 (en) 1996-01-03
DE69518954D1 (de) 2000-11-02
ES2088742B1 (es) 1997-03-16
EP0689832B1 (en) 2000-09-27
DE69518954T2 (de) 2001-04-26
EP0689832A3 (en) 1998-03-11

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