ES2088500T3 - CONTROLLED RELEASE COMPOSITIONS. - Google Patents

CONTROLLED RELEASE COMPOSITIONS.

Info

Publication number
ES2088500T3
ES2088500T3 ES91915434T ES91915434T ES2088500T3 ES 2088500 T3 ES2088500 T3 ES 2088500T3 ES 91915434 T ES91915434 T ES 91915434T ES 91915434 T ES91915434 T ES 91915434T ES 2088500 T3 ES2088500 T3 ES 2088500T3
Authority
ES
Spain
Prior art keywords
complex
active agent
composition
polycarbophil
polymeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915434T
Other languages
Spanish (es)
Inventor
Ramesh N Acharya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Laboratories UT Inc
Original Assignee
Theratech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/570,340 external-priority patent/US5110605A/en
Priority claimed from US07/580,854 external-priority patent/US5102666A/en
Priority claimed from US07/678,814 external-priority patent/US5686094A/en
Application filed by Theratech Inc filed Critical Theratech Inc
Application granted granted Critical
Publication of ES2088500T3 publication Critical patent/ES2088500T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8194—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Lubricants (AREA)

Abstract

A polymeric complex composition comprising a reaction complex formed by the interaction of a polycarbophil component with alginic acid or a salt thereof, said interaction being performed in the presence of a divalent cation and in the presence of an active agent selected from the group consisting of medicinal agents and cosmetic agents. Also disclosed is a polymeric delivery system which is formed by a polycarbophil type composition with an active agent, optionally in the presence of water and/or other cosolvent. There is also described a method of controlled release treatment comprising the steps of providing such a polymeric complex and an effective amount of an active agent selected from the group consisting of medicinal agents and cosmetic agents contained within said complex, and contacting an area of skin or mucous membrane to be treated with said composition for a sufficient period of time to allow a therapeutically effective amount of said active agent to be released from the complex. A composition and method for the treatment of xerostomia is also disclosed, comprising polycarbophil in the form of an article having a shape suitable for insertion into the mouth.
ES91915434T 1990-08-21 1991-08-20 CONTROLLED RELEASE COMPOSITIONS. Expired - Lifetime ES2088500T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/570,340 US5110605A (en) 1990-08-21 1990-08-21 Calcium polycarbophil-alginate controlled release composition and method
US07/580,854 US5102666A (en) 1990-09-11 1990-09-11 Calcium polycarbophil controlled release composition and method
US07/678,814 US5686094A (en) 1991-04-01 1991-04-01 Controlled release formulations for the treatment of xerostomia

Publications (1)

Publication Number Publication Date
ES2088500T3 true ES2088500T3 (en) 1996-08-16

Family

ID=27416097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915434T Expired - Lifetime ES2088500T3 (en) 1990-08-21 1991-08-20 CONTROLLED RELEASE COMPOSITIONS.

Country Status (9)

Country Link
EP (1) EP0497956B1 (en)
JP (1) JP3064417B2 (en)
AT (1) ATE137404T1 (en)
AU (1) AU8444291A (en)
DE (1) DE69119217T2 (en)
DK (1) DK0497956T3 (en)
ES (1) ES2088500T3 (en)
GR (1) GR3020502T3 (en)
WO (1) WO1992003124A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731338A (en) * 1992-07-02 1998-03-24 Oramed, Inc. Controlled release pilocarpine delivery system
EP0659077A1 (en) * 1992-07-02 1995-06-28 TheraTech, Inc. Controlled release pilocarpine delivery system
US5885552A (en) * 1993-01-19 1999-03-23 Gillette Canada Inc. Mouthrinse
DE69330797T2 (en) * 1993-01-19 2002-05-23 Gillette Co Mouthwash
GB2279871B (en) * 1993-06-23 1997-05-07 Jevco Ltd Drug retention systems for use in aquaculture
AU748804B2 (en) * 1995-07-20 2002-06-13 Smithkline Beecham Plc Paroxetine controlled release compositions
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
GB9514842D0 (en) * 1995-07-20 1995-09-20 Smithkline Beecham Plc Novel formulation
US5912007A (en) * 1996-02-29 1999-06-15 Warner-Lambert Company Delivery system for the localized administration of medicaments to the upper respiratory tract and methods for preparing and using same
IT1284874B1 (en) * 1996-08-02 1998-05-22 Farmigea Spa BIOADHESIVE COMPLEXES OF POLYCARBOPHIL AND AZOLIC ANTIFUNGAL OR ANTIPROTOZOAR DRUGS
DE19637792A1 (en) * 1996-09-17 1998-03-19 Huels Chemische Werke Ag Catalytic converter and process for catalytic exhaust gas purification in the DMT process
JP4850709B2 (en) * 2003-05-14 2012-01-11 ダニスコ・ユーエス・インコーポレーテッド Controlled release of active agent using repetitive sequence protein polymer
WO2006013081A1 (en) 2004-08-02 2006-02-09 Glaxo Group Limited Novel composition for xerostomia
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US9017709B2 (en) * 2005-08-11 2015-04-28 Promedon S.A. Composition comprising polymeric, water-insoluble, anionic particles, processes and uses
TW201010743A (en) * 2008-09-05 2010-03-16 Otsuka Pharma Co Ltd Pharmaceutical solid preparation
CA2949304C (en) 2014-05-22 2022-10-25 University Of Copenhagen Aqueous gel composition and its use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU565354B2 (en) * 1983-11-14 1987-09-10 Bio-Mimetics Inc. Bioadhesive compositions and methods of treatment therewith
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
CA2003808C (en) * 1988-11-28 1999-11-09 Eugene Joseph Sehm Crosslinked polyacrylic acid
US4988679A (en) * 1989-01-03 1991-01-29 Leonard Chavkin Liquid sustained release composition
HUT68635A (en) * 1989-10-31 1995-07-28 Columbia Lab Inc Tissue moisturizing composition and process for production of this

Also Published As

Publication number Publication date
AU8444291A (en) 1992-03-17
EP0497956B1 (en) 1996-05-01
DE69119217D1 (en) 1996-06-05
EP0497956A4 (en) 1993-03-31
WO1992003124A1 (en) 1992-03-05
EP0497956A1 (en) 1992-08-12
GR3020502T3 (en) 1996-10-31
DE69119217T2 (en) 1996-10-31
JP3064417B2 (en) 2000-07-12
ATE137404T1 (en) 1996-05-15
DK0497956T3 (en) 1996-08-12
JPH05502894A (en) 1993-05-20

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