ES2085246T1 - Adn que codifica un receptor humano 5-ht1e y utilizaciones del mismo. - Google Patents

Adn que codifica un receptor humano 5-ht1e y utilizaciones del mismo.

Info

Publication number
ES2085246T1
ES2085246T1 ES93900769T ES93900769T ES2085246T1 ES 2085246 T1 ES2085246 T1 ES 2085246T1 ES 93900769 T ES93900769 T ES 93900769T ES 93900769 T ES93900769 T ES 93900769T ES 2085246 T1 ES2085246 T1 ES 2085246T1
Authority
ES
Spain
Prior art keywords
ht1e
human
receptor
nucleic acid
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES93900769T
Other languages
English (en)
Inventor
Richard L Weinshank
Theresa Branchek
Paul R Hartig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synaptic Pharmaceutical Corp
Original Assignee
Synaptic Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synaptic Pharmaceutical Corp filed Critical Synaptic Pharmaceutical Corp
Publication of ES2085246T1 publication Critical patent/ES2085246T1/es
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

ESTA INVENCION PROPORCIONA UNA MOLECULA DE ACIDO NUCLEICO AISLADO QUE CODIFICA UN RECEPTOR 5-HT1E HUMANO, UNA PROTEINA AISLADA QUE ES UN RECEPTOR 5HT1E HUMANO, VECTORES QUE COMPRENDEN UNA MOLECULA DE ACIDO NUCLEICO AISLADO QUE CODIFICA UN RECEPTOR 5-HT1E, CELULAS MAMIFERAS QUE COMPRENDEN TALES VECTORES, ANTICUERPOS DIRIGIDOS A RECEPTOR 5-HT1E SONDAS DE ACIDO NUCLEICO UTIL PARA DETECTAR ACIDO NUCLEICO QUE CODIFICAN RECEPTORES 5-HT1E, OLIGONUCLEOTIDOS OPUESTOS COMPLEMENTARIO A CUALQUIER SECUENCIAS DE UNA MOLECULA DE ACIDO NUCLEICO QUE CODIFICA UN RECEPTOR 5-HT1E HUMANO, COMPUESTOS FARMACEUTICOS REFERIDOS A RECEPTORES 5-HT1E HUMANOS, Y ANIMALES TRANSGENICOS NO HUMANOS QUE EXPRESAN ADN QUE CODIFICA UN RECEPTOR 5.HT1E HUMANO NORMAL O MUTANTE. ESTA INVENCION SE REFIERE ADEMAS A METODOS PARA DETERMINAR ENLACES DE LIGANDOS, DETECTAR EXPRESIONES, FILTRAR MEDICAMENTOS, Y TRATAMIENTO QUE CONLLEVAN EL RECEPTOR 5-HT1E HUMANO.
ES93900769T 1991-12-02 1992-12-02 Adn que codifica un receptor humano 5-ht1e y utilizaciones del mismo. Pending ES2085246T1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80362691A 1991-12-02 1991-12-02

Publications (1)

Publication Number Publication Date
ES2085246T1 true ES2085246T1 (es) 1996-06-01

Family

ID=25187041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900769T Pending ES2085246T1 (es) 1991-12-02 1992-12-02 Adn que codifica un receptor humano 5-ht1e y utilizaciones del mismo.

Country Status (10)

Country Link
US (3) US5476782A (es)
EP (1) EP0585415B1 (es)
JP (1) JPH06508764A (es)
AT (1) ATE292175T1 (es)
AU (1) AU672768B2 (es)
CA (1) CA2101162A1 (es)
DE (2) DE585415T1 (es)
ES (1) ES2085246T1 (es)
GR (1) GR960300015T1 (es)
WO (1) WO1993011147A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5661024A (en) 1989-10-31 1997-08-26 Synaptic Pharmaceutical Corporation DNA encoding a human serotonic (5-HT2) receptor and uses thereof
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
DE585415T1 (de) * 1991-12-02 1996-10-10 Synaptic Pharma Corp Dns-kodierend für den menschlichen 5-ht 1e rezeptor und seine verwendung.
US6406859B1 (en) * 1992-01-08 2002-06-18 Synaptic Pharmaceutical Corporation DNA encoding a 5-HT 1F receptor and uses thereof
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
EP0624100B1 (en) 1992-11-03 2000-05-03 Synaptic Pharmaceutical Corporation Dna encoding a human serotonin receptor (5-ht 4b) and uses thereof
US6300087B1 (en) 1992-11-03 2001-10-09 Synaptic Pharmaceutical Corporation DNA encoding a human serotonin receptor (5-HT4B) and uses thereof
US5472866A (en) * 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors
US20020115149A1 (en) * 1993-01-08 2002-08-22 Synaptic Pharmaceutical Corporation DNA encoding human 5-HT1D receptors and uses thereof
EP0665887B1 (en) * 1993-08-20 1998-10-14 Smithkline Beecham Plc Human 5-ht 2? receptor
US5698766A (en) * 1995-04-05 1997-12-16 The Regents Of The University Of California Transgenic animal model for testing drugs for treating eating disorders and epilepsy
US6221660B1 (en) 1999-02-22 2001-04-24 Synaptic Pharmaceutical Corporation DNA encoding SNORF25 receptor
WO2004087882A2 (en) * 2003-03-26 2004-10-14 Washington University Neuregulin protein regulation of synaptic proteins
US20070270339A1 (en) * 2004-04-23 2007-11-22 Serono, Inc. Use of GPCR54 Ligands for the Treatment of Infertility
DE102004026744A1 (de) * 2004-05-28 2005-12-29 Philipps-Universität Marburg Erfindung betreffend cDNA-Herstellung aus Zellen nach Laser-Mikrodissektion
US20080014172A1 (en) * 2004-05-28 2008-01-17 Applied Research Systems Ars Holding N.V. Use of Il-17 in the Treatment of Fertility-Related Disorders
JP4286877B2 (ja) * 2007-03-13 2009-07-01 Okiセミコンダクタ株式会社 炭化珪素半導体装置およびその製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4985352A (en) * 1988-02-29 1991-01-15 The Trustees Of Columbia University In The City Of New York DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof
FR2628750B1 (fr) * 1988-03-21 1991-11-08 Pasteur Institut Vecteur modifie par une sequence codant pour une sequence d'acides amines contenue dans une proteine de mammifere ayant une activite biologique de recepteur membranaire
US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
DE585415T1 (de) * 1991-12-02 1996-10-10 Synaptic Pharma Corp Dns-kodierend für den menschlichen 5-ht 1e rezeptor und seine verwendung.
US5360735A (en) * 1992-01-08 1994-11-01 Synaptic Pharmaceutical Corporation DNA encoding a human 5-HT1F receptor, vectors, and host cells
GB2267906A (en) * 1992-06-11 1993-12-22 Merck Sharp & Dohme Human brain serotonin receptor
US5472866A (en) * 1992-12-24 1995-12-05 Synaptic Pharmaceutical Corporation DNA encoding 5-HT4A serotonin receptors

Also Published As

Publication number Publication date
WO1993011147A1 (en) 1993-06-10
AU3233893A (en) 1993-06-28
CA2101162A1 (en) 1993-06-03
US6096507A (en) 2000-08-01
AU672768B2 (en) 1996-10-17
US5476782A (en) 1995-12-19
US5786155A (en) 1998-07-28
EP0585415B1 (en) 2005-03-30
DE69233496D1 (de) 2005-05-04
GR960300015T1 (es) 1996-03-31
EP0585415A4 (es) 1994-04-13
EP0585415A1 (en) 1994-03-09
ATE292175T1 (de) 2005-04-15
JPH06508764A (ja) 1994-10-06
DE585415T1 (de) 1996-10-10

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