ES2083324B1 - PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES. - Google Patents

PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES.

Info

Publication number
ES2083324B1
ES2083324B1 ES9302366A ES9302366A ES2083324B1 ES 2083324 B1 ES2083324 B1 ES 2083324B1 ES 9302366 A ES9302366 A ES 9302366A ES 9302366 A ES9302366 A ES 9302366A ES 2083324 B1 ES2083324 B1 ES 2083324B1
Authority
ES
Spain
Prior art keywords
nitrils
procedure
obtaining
solvent
ketoacides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9302366A
Other languages
Spanish (es)
Other versions
ES2083324A1 (en
Inventor
Sanchidrian Cesar Jimenez
Arrebola Jose Rafael Ruiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Cordoba
Original Assignee
Universidad de Cordoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Cordoba filed Critical Universidad de Cordoba
Priority to ES9302366A priority Critical patent/ES2083324B1/en
Publication of ES2083324A1 publication Critical patent/ES2083324A1/en
Application granted granted Critical
Publication of ES2083324B1 publication Critical patent/ES2083324B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PROCEDIMIENTO DE OBTENCION DE NITRILOS A PARTIR DE AL CETOACIDOS. COMPRENDE: HACER REACCIONAR (II) CON HIDROXILAMINA O UN DERIVADO REACTIVO DE LA MISMA, EN PRESENCIA DE UN ALCOHOL ALIFATICO DE BAJO PESO MOLECULAR COMO DISOLVENTE Y DE PIRIDINA COMO CATALIZADOR, A LA TEMPERATURA DE REFLUJO DEL DISOLVENTE, CON AGITACION Y DURANTE UN PERIODO DE TIEMPO COMPRENDIDO ENTRE 14 Y 30 HORAS PARA PRODUCIR UNA CETOXIMA INTERMEDIA QUE NO SE AISLA DEL MEDIO DE REACCION Y QUE SE DESCARBOXILA ESPONTANEAMENTE EN ESTAS CONDICIONES PARA PRODUCIR EL NITRITO (I). EN LAS FORMULAS R1 REPRESENTA UN RADICAL ORGANICO ALIFATICO O AROMATICO. LOS COMPUESTOS (I) TIENEN GRAN APLICACION COMO INTERMEDIOS EN EL CAMPO QUIMICO DE LA SINTESIS ORGANICA.PROCEDURE FOR OBTAINING NITRILS FROM AL CETOACIDOS. UNDERSTANDS: REACTING (II) WITH HYDROXYLAMINE OR A REACTIVE DERIVATIVE OF THE SAME, IN THE PRESENCE OF A LOW MOLECULAR ALIFATIC ALCOHOL AS A SOLVENT AND OF PIRIDINE AS A CATALYST, AT THE SOLVENT'S REFLUX TEMPERATURE, WITH TIME INCLUDED BETWEEN 14 AND 30 HOURS TO PRODUCE AN INTERMEDIATE CETOXIME THAT IS NOT ISOLATED FROM THE REACTION MEDIA AND SPONTANEOUSLY DECARBOXYLATED IN THESE CONDITIONS TO PRODUCE NITRITE (I). IN FORMULAS R1 IT REPRESENTS AN ORGANIC ALIPHATIC OR AROMATIC RADICAL. COMPOUNDS (I) HAVE GREAT APPLICATION AS INTERMEDIATES IN THE CHEMICAL FIELD OF ORGANIC SYNTHESIS.

ES9302366A 1993-11-12 1993-11-12 PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES. Expired - Fee Related ES2083324B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9302366A ES2083324B1 (en) 1993-11-12 1993-11-12 PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9302366A ES2083324B1 (en) 1993-11-12 1993-11-12 PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES.

Publications (2)

Publication Number Publication Date
ES2083324A1 ES2083324A1 (en) 1996-04-01
ES2083324B1 true ES2083324B1 (en) 1996-12-16

Family

ID=8283590

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9302366A Expired - Fee Related ES2083324B1 (en) 1993-11-12 1993-11-12 PROCEDURE FOR OBTAINING NITRILS FROM ALPHA-KETOACIDES.

Country Status (1)

Country Link
ES (1) ES2083324B1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU679576A1 (en) * 1977-07-15 1979-08-15 Предприятие П/Я В-8415 Method of obtaining nitriles of carbolic acids
DE3036281A1 (en) * 1980-09-26 1982-05-13 Boehringer Mannheim Gmbh, 6800 Mannheim 0-SUBSTITUTED PETROLEUM ACID OXIMES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5281744A (en) * 1992-03-02 1994-01-25 Shell Oil Company Process for the preparation of nitriles

Also Published As

Publication number Publication date
ES2083324A1 (en) 1996-04-01

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