ES2081251B1 - ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE. - Google Patents

ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE.

Info

Publication number
ES2081251B1
ES2081251B1 ES9301747A ES9301747A ES2081251B1 ES 2081251 B1 ES2081251 B1 ES 2081251B1 ES 9301747 A ES9301747 A ES 9301747A ES 9301747 A ES9301747 A ES 9301747A ES 2081251 B1 ES2081251 B1 ES 2081251B1
Authority
ES
Spain
Prior art keywords
sulfonamide
endotheline
endotheline antagonists
antagonists
alcoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9301747A
Other languages
Spanish (es)
Other versions
ES2081251A1 (en
Inventor
Philip D Stein
John T Hunt
Natesan Murugesan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to ES9301747A priority Critical patent/ES2081251B1/en
Publication of ES2081251A1 publication Critical patent/ES2081251A1/en
Application granted granted Critical
Publication of ES2081251B1 publication Critical patent/ES2081251B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

ANTAGONISTAS DE ENDOTELINA A BASE DE SULFONAMIDA QUE TIENEN LA FORMULA: *FIG* EN DONDE R ES NAFTILO SUSTITUIDO O SIN SUSTITUIR, R4 Y R5 SON CADA UNO, INDEPENDIENTEMENTE, HIDROGENO, HALO, HIDROXILO, CIANO, NITRO, ALQUILO, ALQUENILO, ALQUINILO, ALCOXI Y OTROS RADICALES ORGANICOS, O BIEN R4 Y R5 SON CONJUNTAMENTE ALQUILENO O ALQUENILENO, COMPLETANDO UN ANILLO DE 4 A 8 MIEMBROS, SATURADO, INSATURADO O AROMATICO, JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES VAN UNIDOS, Y UNO DE X E Y ES N Y EL OTRO ES O. ESTOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA ENDOTELINA Y TIENEN UTILIDAD PARA EL TRATAMIENTO DE LA HIPERTENSION.Endothelin antagonists BASED sulfonamide having the formula: * FIG * wherein R is naphthyl unsubstituted or substituted, R4 and R5 are each independently hydrogen, halo, hydroxy, cyano, nitro, alkyl, alkenyl, alkynyl, ALCOXI AND OTHER ORGANIC RADICALS, OR R4 AND R5 ARE TOGETHER ALKYLENE OR ALKENYLENE, COMPLETING A RING OF 4 TO 8 MEMBERS, SATURATED, UNSATURATED OR AROMATIC, TOGETHER WITH WHICH AND ONE OF THEM ARE UNITED. THE OTHER IS O. THESE COMPOUNDS ARE INHIBITORS OF ENDOTHELINE ACTIVITY AND HAVE USEFULNESS FOR THE TREATMENT OF HYPERTENSION.

ES9301747A 1993-08-04 1993-08-04 ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE. Expired - Fee Related ES2081251B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9301747A ES2081251B1 (en) 1993-08-04 1993-08-04 ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9301747A ES2081251B1 (en) 1993-08-04 1993-08-04 ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE.

Publications (2)

Publication Number Publication Date
ES2081251A1 ES2081251A1 (en) 1996-02-16
ES2081251B1 true ES2081251B1 (en) 1996-10-16

Family

ID=8282779

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9301747A Expired - Fee Related ES2081251B1 (en) 1993-08-04 1993-08-04 ENDOTHELINE ANTAGONISTS, BASED ON SULFONAMIDE.

Country Status (1)

Country Link
ES (1) ES2081251B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224462B (en) * 1992-02-24 1994-06-01 Squibb & Sons Inc

Also Published As

Publication number Publication date
ES2081251A1 (en) 1996-02-16

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