ES2065269A1 - 6-[4-(phenylbutoxy)] hexylaminomethyl-4-hydroxy- [alpha]1,[alpha]3-benzenodimethanol. Procedure for obtaining it and new intermediates used in the preparation thereof - Google Patents
6-[4-(phenylbutoxy)] hexylaminomethyl-4-hydroxy- [alpha]1,[alpha]3-benzenodimethanol. Procedure for obtaining it and new intermediates used in the preparation thereofInfo
- Publication number
- ES2065269A1 ES2065269A1 ES09300996A ES9300996A ES2065269A1 ES 2065269 A1 ES2065269 A1 ES 2065269A1 ES 09300996 A ES09300996 A ES 09300996A ES 9300996 A ES9300996 A ES 9300996A ES 2065269 A1 ES2065269 A1 ES 2065269A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- phenylbutoxy
- procedure
- benzenodimethanol
- hexylaminomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
6-[4-(phenylbutoxy)] hexylaminomethyl-4-hydroxy- [alpha]1,[alpha]3-benzenodimethanol. Procedure for obtaining it and new intermediates used in the preparation thereof. The object of the invention is a new procedure for obtaining 6-[4-(phenylbutoxy)] hexylaminomethyl-4-hydroxy- [alpha]1,[alpha]3-benzenodimethanol of formula (I). Such procedure consists in the hydrogenation of the new intermediate 5-[(6-(4- (phenylbutoxy)hexyl)benzylaminoacetyl] salicylaldehyde of formula (XIV), which in turn is obtained from the condensation between 5-bromoacetylsalicylaldehyde and 6- [4-(phenylbutoxy)] hexylbenzylamine. The transformation (XIV) in (I) is carried out in a single step and without the detection of lateral reactions, thus substantially shortening the synthetic procedures published to date in the literature.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9300996A ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9300996A ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2065269A1 true ES2065269A1 (en) | 1995-02-01 |
ES2065269B1 ES2065269B1 (en) | 1995-10-01 |
Family
ID=8281755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9300996A Expired - Fee Related ES2065269B1 (en) | 1993-05-11 | 1993-05-11 | 6- (4- (FENILBUTOXI) HEXILAMINOMETIL-4-HIDROXI-A1, A3-BENCENODIMETANOL. PROCEDURE FOR THE OBTAINING OF THE SAME AND NEW INTERMEDIATES USED IN ITS PREPARATION. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2065269B1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2142771A1 (en) * | 1998-09-28 | 2000-04-16 | Vita Invest Sa | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
ES2288114A1 (en) * | 2006-04-26 | 2007-12-16 | Quimica Sintetica S.A. | Synthesizing method for salmeterol xinafoate, involves preparing specific compound and pharmaceutically acceptable salts, and compound obtained is used as intermediate |
WO2012032546A2 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Process for the preparation of salmeterol and its intermediates |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8505641A1 (en) * | 1983-04-18 | 1985-06-01 | Glaxo Group Ltd | Phenethanolamine derivatives |
EP0422889A2 (en) * | 1989-10-10 | 1991-04-17 | Glaxo Group Limited | Phenethanolamine compounds |
-
1993
- 1993-05-11 ES ES9300996A patent/ES2065269B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8505641A1 (en) * | 1983-04-18 | 1985-06-01 | Glaxo Group Ltd | Phenethanolamine derivatives |
ES8609209A1 (en) * | 1983-04-18 | 1986-07-16 | Glaxo Group Ltd | Phenethanolamine derivatives |
EP0422889A2 (en) * | 1989-10-10 | 1991-04-17 | Glaxo Group Limited | Phenethanolamine compounds |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2142771A1 (en) * | 1998-09-28 | 2000-04-16 | Vita Invest Sa | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
WO2000018722A3 (en) * | 1998-09-28 | 2000-07-06 | Vita Invest Sa | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
EA003397B1 (en) * | 1998-09-28 | 2003-04-24 | Вита-Инвест, С.А. | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
CZ296901B6 (en) * | 1998-09-28 | 2006-07-12 | Vita Cientifica | Process for preparing Salmeterol and 6-(4-phenylbutoxy)hexylamine derivatives |
CZ296902B6 (en) * | 1998-09-28 | 2006-07-12 | Vita Cientifica | Process for preparing 6-(4-phenylbutoxy)hexylamine derivative |
ES2288114A1 (en) * | 2006-04-26 | 2007-12-16 | Quimica Sintetica S.A. | Synthesizing method for salmeterol xinafoate, involves preparing specific compound and pharmaceutically acceptable salts, and compound obtained is used as intermediate |
WO2012032546A2 (en) | 2010-09-08 | 2012-03-15 | Cadila Healthcare Limited | Process for the preparation of salmeterol and its intermediates |
Also Published As
Publication number | Publication date |
---|---|
ES2065269B1 (en) | 1995-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20020401 |