ES2062985T3 - Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. - Google Patents

Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.

Info

Publication number
ES2062985T3
ES2062985T3 ES87308921T ES87308921T ES2062985T3 ES 2062985 T3 ES2062985 T3 ES 2062985T3 ES 87308921 T ES87308921 T ES 87308921T ES 87308921 T ES87308921 T ES 87308921T ES 2062985 T3 ES2062985 T3 ES 2062985T3
Authority
ES
Spain
Prior art keywords
preparation
compounds
procedure
hydroxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87308921T
Other languages
English (en)
Inventor
Edward C Taylor
George S K Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Application granted granted Critical
Publication of ES2062985T3 publication Critical patent/ES2062985T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PREPARAN 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-EN-IL]PIRIDO [2,3-D]PIRIMIDINAS Y 2-AMINO-4-HIDROXI-6[2-(4-CARBOXIFENIL)ALQU-1-IN-IL] PIRIDO[2,3-D]PIRIMIDINAS A TRAVES DE LA REACCION DE UN COMPUESTO HALOAROMATICO Y UN COMPUESTO NO SATURADO EN PRESENCIA DE UN CATALIZADOR DE PALADIO. LOS PRODUCTOS SON INTERMEDIOS QUIMICOS PARA LA OBTENCION DE AGENTES ANTINEOPLASTICOS. UNA INCORPORACION TIPICA ES LA REACCION DE UNA 2-AMINO-4-HIDROXI-6-ETINILPIRIDO[2,3-D]PIRIMIDINA Y UN ESTER DE ACIDO 4-YODOBENZOICO.
ES87308921T 1986-10-20 1987-10-08 Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado. Expired - Lifetime ES2062985T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/922,511 US4818819A (en) 1986-10-20 1986-10-20 Process for the preparation of fused pyridine compounds

Publications (1)

Publication Number Publication Date
ES2062985T3 true ES2062985T3 (es) 1995-01-01

Family

ID=25447136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87308921T Expired - Lifetime ES2062985T3 (es) 1986-10-20 1987-10-08 Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.

Country Status (7)

Country Link
US (1) US4818819A (es)
EP (1) EP0265126B1 (es)
JP (2) JPH07103120B2 (es)
AT (1) ATE104297T1 (es)
CA (1) CA1301157C (es)
DE (1) DE3789599T2 (es)
ES (1) ES2062985T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US5008391A (en) * 1989-07-07 1991-04-16 Eli Lilly And Company Enantioselective synthesis of antifolates
IL96531A (en) * 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
US6762188B1 (en) 1990-06-19 2004-07-13 Smithkline Beecham Corporation Pharmaceutically active benzoquinazoline compounds
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates
DE69618875D1 (de) * 1995-09-08 2002-03-14 Univ Princeton Nicht-klassische Antifolate
BR0213233A (pt) 2001-10-12 2005-01-04 Warner Lambert Co Alcinos inibidores de metaloproteinase de matriz
WO2003033477A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor
PE20030541A1 (es) * 2001-10-12 2003-08-13 Warner Lambert Co Compuestos pirimidina de anillo fusionado alquinilado como inhibidores de metaloproteasa de matriz tipo 13
WO2004007469A1 (en) * 2002-07-12 2004-01-22 Warner-Lambert Company Llc New alkynylated quinazolin compounds as mmp-13 inhibitors
US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US6894057B2 (en) * 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) * 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
WO2004006914A1 (en) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combination of an allosteric alkyne inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
MXPA05000638A (es) * 2002-07-17 2005-03-31 Warner Lambert Co Combinacion de un inhibidor alquino alosterico de metaloproteinasa-13 de matriz con un inhibidor selectivo de ciclooxigenasa-2 que no es celecoxib o valdecoxib.
WO2005016926A1 (en) * 2003-08-19 2005-02-24 Warner-Lambert Company Llc Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
GB0428475D0 (en) * 2004-12-30 2005-02-02 4 Aza Bioscience Nv Pyrido(3,2-D)pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
GB0503506D0 (en) * 2005-02-21 2005-03-30 4 Aza Bioscience Nv Substituted pyrido(2,3-d) pyrimidine derivatives and pharmaceutical compositions useful as medicines for the treatment of autoimmune disorders
AU2006261607A1 (en) * 2005-06-24 2006-12-28 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines and pharmaceutical compositions useful for treating hepatitis C.
US8338435B2 (en) * 2006-07-20 2012-12-25 Gilead Sciences, Inc. Substituted pyrido(3,2-D) pyrimidines and pharmaceutical compositions for treating viral infections
TW200840584A (en) * 2006-12-26 2008-10-16 Gilead Sciences Inc Pyrido(3,2-d)pyrimidines useful for treating viral infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
IE45338B1 (en) * 1976-03-05 1982-08-11 Stanford Research Inst Composition for treating leukemia and ascites tumour
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4172200A (en) * 1978-06-15 1979-10-23 Southern Research Institute Process for the preparation of 10-deazaaminopterin and related compounds
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
US4512992A (en) * 1980-06-13 1985-04-23 Burroughs Wellcome Co. Treatment with dialkoxy pyridopyrimidine compounds
US4431805A (en) * 1981-09-25 1984-02-14 Southern Research Institute Pyrido[2,3-d]-pyrimidines
US4526964A (en) * 1982-01-11 1985-07-02 Southern Research Institute 2,4-Diamino-6-(hydroxymethyl)pyrido[2,3-d]pyrimidine
US4536575A (en) * 1982-01-11 1985-08-20 Southern Research Institute 2-Amino-4(3H)-oxopyrido[2,3-d]pyrimidino
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US4532241A (en) * 1982-08-26 1985-07-30 Sri International 8,10-Dideazaminopterins
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
JPS61500845A (ja) * 1983-12-27 1986-05-01 エス・ア−ル・アイ・インタ−ナシヨナル ８，１０―ジデアザミノプテリン及び抗白血病剤組成物
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives

Also Published As

Publication number Publication date
JPH07103120B2 (ja) 1995-11-08
EP0265126A3 (en) 1989-08-30
US4818819A (en) 1989-04-04
DE3789599D1 (de) 1994-05-19
JPS63183580A (ja) 1988-07-28
CA1301157C (en) 1992-05-19
JP2558086B2 (ja) 1996-11-27
JPH08119968A (ja) 1996-05-14
ATE104297T1 (de) 1994-04-15
DE3789599T2 (de) 1994-07-21
EP0265126A2 (en) 1988-04-27
EP0265126B1 (en) 1994-04-13

Similar Documents

Publication Publication Date Title
ES2062985T3 (es) Procedimiento para la preparacion de compuestos con un anillo de piridina fusionado.
NO904625L (no) Fremgangsmaate for fremstilling av 1h-imidazo 4,5-c kinoliner.
FI902661A0 (fi) Menetelmä angiotensiini-II-antagonisteina aktiivisten 3-(2'-(substituoitu)bifen-4-yyli)metyyli-3H-imidatso/4,5-b/pyridiiniyhdisteiden valmistamiseksi
NL185518C (nl) Werkwijze voor het continu bereiden van hoogmoleculair polybutyleentereftalaat.
BR8803454A (pt) Processo para preparacao de composto de acido piridina-2,3-dicarboxilico
HU906028D0 (en) Process for the preparation of pyridine and pyrimidine anthranilic acid derivatives and medical preparations containing them
NO863228D0 (no) Fremgangsmaate for fremstilling av farmakodynamiske aktive benzimidazol-derivater.
NO880556L (no) Pyridin-2,4- og 2,5-dikarboksylsyrederivater, samt fremgangsmaater for fremstilling av forbindelsene.
NO881333D0 (no) Fremgangsmaate for fremstilling av imidazo-pyridinderivater
IL81042A0 (en) Pyridine derivatives and n-oxides thereof,processes for their preparation and the use thereof as intermediates
ES525689A0 (es) Procedimiento para la obtencion de imidazo (1,5-a)piridinas
ES2080200T3 (es) Procedimiento para la preparacion de derivados de fosfatidilcolina.
MX161035A (es) Procedimiento para la preparacion de imidazo(1,2-a)quinolinas
DE3680615D1 (de) Verwendung von 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridin zur herstellung antirheumatischer arzneimittel.
FR2581641B1 (fr) Procede de preparation d'acides 6-alkoxy(inferieur)-1-naphtoiques et des esters correspondants et utilisation de ce procede pour la preparation d'acides 6-alkoxy(inferieur)-5-halo-1-naphtoiques et des esters correspondants
ZA876838B (en) Method for the preparation of pyridine-2,3-dicarboxylic acids
ATE45578T1 (de) Synthese von inotropem imidazo(4,5-c>pyridin.
IT1201418B (it) Procedimento per la preparazione di triidrato di acido 8-etil-5,8-diidro-5-ossi-2-(1piperazinil)pirido 2,3-d piramidin-6-carbossilico
PT82243A (fr) Procede de preparation de nouvelles 5-h pyrido<3',4':4,5>pyrrolo<3,2-c>pyridines
NO166128C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo(1,2-a)pyridinderivater.
PT81894A (en) Process for the preparation of 1,6-naphthyridin-2(1h)-ones having cardiotonic activity
IT1197876B (it) Procedimento per la preparazione dell'acido 5,8-diidro-8-etil-5-osso-2-(1-piperazinil)pirido(2,3-d)pirimidin-6-carbossilico
IT8921175A0 (it) Procedimento per la preparazione di acido metossiacetico.
IT8247962A0 (it) Procedimento per la preparazione di acidi 6-[d(-)-alfa-(4-c1-c4-alchil2,3-diosso-1-piperazinocarbonilammino) fenilacetammido] penicillanici
KR890701586A (ko) 이환식 화합물, 이의 약제로서의 용도, 이의 제조방법 및 이의 제조에 유용한 중간체

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 265126

Country of ref document: ES