ES2056728A1 - New derivatives of piperidyl and aminoalkyl with 5-HT4 receptor antagonistic activity - Google Patents

New derivatives of piperidyl and aminoalkyl with 5-HT4 receptor antagonistic activity

Info

Publication number
ES2056728A1
ES2056728A1 ES09202166A ES9202166A ES2056728A1 ES 2056728 A1 ES2056728 A1 ES 2056728A1 ES 09202166 A ES09202166 A ES 09202166A ES 9202166 A ES9202166 A ES 9202166A ES 2056728 A1 ES2056728 A1 ES 2056728A1
Authority
ES
Spain
Prior art keywords
piperidyl
aminoalkyl
antagonistic activity
receptor antagonistic
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202166A
Other languages
Spanish (es)
Other versions
ES2056728B1 (en
Inventor
Francias David King
Laramie Mary Gaster
Graham Francis Joiner
Shirley K Rahman
Gareth John Sanger
Kay Alison Wardle
Gordon Smith Baxter
Guy Anthony Kennett
Rodney C Young
Alberto Julio Kaumann
Mythily Vimal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to ES9202166A priority Critical patent/ES2056728B1/en
Publication of ES2056728A1 publication Critical patent/ES2056728A1/en
Application granted granted Critical
Publication of ES2056728B1 publication Critical patent/ES2056728B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

New derivatives of piperidyl and aminoalkyl with 5-HT4 receptor antagonistic activity. Said derivatives have the formula X-CO-Y-Z (I), in which X is selected from the groups (a, b and c), in which the different symbols represent organic radicals Y represents O or NH and Z represents a group of formula (d) or (e) in which n1, n2 and q represent zero or a whole number and the remaining symbols represent organic radicals. These compounds have application in the treatment of gastrointestinal, cardiovascular and central nervous system disorders.
ES9202166A 1992-10-28 1992-10-28 NEW PIPERIDILE AND AMINOALKYL DERIVATIVES WITH ANTAGONIST ACTIVITY OF THE 5-HT4 RECEPTOR Expired - Lifetime ES2056728B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9202166A ES2056728B1 (en) 1992-10-28 1992-10-28 NEW PIPERIDILE AND AMINOALKYL DERIVATIVES WITH ANTAGONIST ACTIVITY OF THE 5-HT4 RECEPTOR

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202166A ES2056728B1 (en) 1992-10-28 1992-10-28 NEW PIPERIDILE AND AMINOALKYL DERIVATIVES WITH ANTAGONIST ACTIVITY OF THE 5-HT4 RECEPTOR

Publications (2)

Publication Number Publication Date
ES2056728A1 true ES2056728A1 (en) 1994-10-01
ES2056728B1 ES2056728B1 (en) 1995-05-01

Family

ID=8278596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202166A Expired - Lifetime ES2056728B1 (en) 1992-10-28 1992-10-28 NEW PIPERIDILE AND AMINOALKYL DERIVATIVES WITH ANTAGONIST ACTIVITY OF THE 5-HT4 RECEPTOR

Country Status (1)

Country Link
ES (1) ES2056728B1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125398A (en) * 1982-06-29 1984-03-07 Sandoz Ltd Bridged piperidyl esters and amides
EP0189002A2 (en) * 1984-12-20 1986-07-30 Sandoz Ag Treatment of gastrointestinal disorders using 5-HT3 antagonists
EP0200444A2 (en) * 1985-04-27 1986-11-05 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity
EP0429984A2 (en) * 1989-11-17 1991-06-05 Nisshin Flour Milling Co., Ltd. Indole derivatives
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2125398A (en) * 1982-06-29 1984-03-07 Sandoz Ltd Bridged piperidyl esters and amides
EP0189002A2 (en) * 1984-12-20 1986-07-30 Sandoz Ag Treatment of gastrointestinal disorders using 5-HT3 antagonists
EP0200444A2 (en) * 1985-04-27 1986-11-05 Beecham Group Plc Azabicyclononyl-indazole-carboxamide having 5-HT antagonist activity
EP0429984A2 (en) * 1989-11-17 1991-06-05 Nisshin Flour Milling Co., Ltd. Indole derivatives
WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists

Also Published As

Publication number Publication date
ES2056728B1 (en) 1995-05-01

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