ES2053402A1 - Method for preparation of inactivated vaccines and live adjuvant-enhanced vaccines, as well as the vaccines obtained by said method - Google Patents

Method for preparation of inactivated vaccines and live adjuvant-enhanced vaccines, as well as the vaccines obtained by said method

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Publication number
ES2053402A1
ES2053402A1 ES09300070A ES9300070A ES2053402A1 ES 2053402 A1 ES2053402 A1 ES 2053402A1 ES 09300070 A ES09300070 A ES 09300070A ES 9300070 A ES9300070 A ES 9300070A ES 2053402 A1 ES2053402 A1 ES 2053402A1
Authority
ES
Spain
Prior art keywords
vaccines
live
adjuvant
emulsion
enhanced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09300070A
Other languages
Spanish (es)
Other versions
ES2053402B1 (en
Inventor
Gifre Juan Nogareda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Hipra SA
Original Assignee
Laboratorios Hipra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Hipra SA filed Critical Laboratorios Hipra SA
Priority to ES9300070A priority Critical patent/ES2053402B1/en
Publication of ES2053402A1 publication Critical patent/ES2053402A1/en
Application granted granted Critical
Publication of ES2053402B1 publication Critical patent/ES2053402B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

Method for preparation of inactivated vaccines and live adjuvant-enhanced vaccines, as well as the vaccines obtained by said method. The method produces vaccines which contain one or more antigenic fractions presented in the galenical form of an oil-in-water (O/W) emulsion. This method allows live freeze-dried vaccines to be dissolved in the O/W emulsion, and uses an ultrasound generator to reduce the droplet size of the emulsion, allowing the proportion of emulsifiers needed for formulation of the emulsion to be reduced. The method is used to prepare inactivated vaccines and live adjuvant-enhanced vaccines which produce a positive effect in obtaining a higher level of humoral antibodies.
ES9300070A 1993-01-15 1993-01-15 PREPARATION METHOD FOR INACTIVATED VACCINES AND ADJUVANT LIVING VACCINES AS WELL AS VACCINES OBTAINED BY SUCH METHOD. Expired - Lifetime ES2053402B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9300070A ES2053402B1 (en) 1993-01-15 1993-01-15 PREPARATION METHOD FOR INACTIVATED VACCINES AND ADJUVANT LIVING VACCINES AS WELL AS VACCINES OBTAINED BY SUCH METHOD.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9300070A ES2053402B1 (en) 1993-01-15 1993-01-15 PREPARATION METHOD FOR INACTIVATED VACCINES AND ADJUVANT LIVING VACCINES AS WELL AS VACCINES OBTAINED BY SUCH METHOD.

Publications (2)

Publication Number Publication Date
ES2053402A1 true ES2053402A1 (en) 1994-07-16
ES2053402B1 ES2053402B1 (en) 1995-02-01

Family

ID=8280472

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9300070A Expired - Lifetime ES2053402B1 (en) 1993-01-15 1993-01-15 PREPARATION METHOD FOR INACTIVATED VACCINES AND ADJUVANT LIVING VACCINES AS WELL AS VACCINES OBTAINED BY SUCH METHOD.

Country Status (1)

Country Link
ES (1) ES2053402B1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8502870A1 (en) * 1983-06-06 1985-02-01 Duphar Int Res Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained.
ES8704352A1 (en) * 1984-11-23 1987-04-16 Schering Ag Magnetic particles for diagnostic purposes.
EP0242205A2 (en) * 1986-04-18 1987-10-21 Smithkline Beecham Corporation Vaccine formulation
ES8802209A1 (en) * 1985-02-10 1988-05-01 Israel Mini Agricult Vaccine system
EP0279641A2 (en) * 1987-02-19 1988-08-24 Unilever Plc Cosmetic compositions
ES2005167A6 (en) * 1986-04-15 1989-03-01 Ribi Immunochem Research Inc Immunological adjuvant enhancing immune response to vaccine antigens
EP0315153A2 (en) * 1987-11-03 1989-05-10 Syntex (U.S.A.) Inc. Vaccine adjuvant

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8502870A1 (en) * 1983-06-06 1985-02-01 Duphar Int Res Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained.
ES8704352A1 (en) * 1984-11-23 1987-04-16 Schering Ag Magnetic particles for diagnostic purposes.
ES8802209A1 (en) * 1985-02-10 1988-05-01 Israel Mini Agricult Vaccine system
ES2005167A6 (en) * 1986-04-15 1989-03-01 Ribi Immunochem Research Inc Immunological adjuvant enhancing immune response to vaccine antigens
EP0242205A2 (en) * 1986-04-18 1987-10-21 Smithkline Beecham Corporation Vaccine formulation
EP0279641A2 (en) * 1987-02-19 1988-08-24 Unilever Plc Cosmetic compositions
EP0315153A2 (en) * 1987-11-03 1989-05-10 Syntex (U.S.A.) Inc. Vaccine adjuvant

Also Published As

Publication number Publication date
ES2053402B1 (en) 1995-02-01

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Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19950920