ES2051226A1 - Procedure for obtaining (-)-(2R,3R)-2-(2,4- dichlorophenyl)-3-(N-methanosulphonyl-N-methylamino)-1- (1H-1,2,4-triazol-1-yl)-2-butanol - Google Patents

Procedure for obtaining (-)-(2R,3R)-2-(2,4- dichlorophenyl)-3-(N-methanosulphonyl-N-methylamino)-1- (1H-1,2,4-triazol-1-yl)-2-butanol

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Publication number
ES2051226A1
ES2051226A1 ES09201562A ES9201562A ES2051226A1 ES 2051226 A1 ES2051226 A1 ES 2051226A1 ES 09201562 A ES09201562 A ES 09201562A ES 9201562 A ES9201562 A ES 9201562A ES 2051226 A1 ES2051226 A1 ES 2051226A1
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ES
Spain
Prior art keywords
methanosulphonyl
procedure
triazol
dichlorophenyl
methylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09201562A
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Spanish (es)
Other versions
ES2051226B1 (en
Inventor
Javier Bartroli
Manuel Anguita
Jordi Belloc
Elena Carceller
Carmen Almansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
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Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES9201562A priority Critical patent/ES2051226B1/en
Publication of ES2051226A1 publication Critical patent/ES2051226A1/en
Application granted granted Critical
Publication of ES2051226B1 publication Critical patent/ES2051226B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedure for obtaining (-)-(2R,3R)-2-(2,4- dichlorophenyl)-3-(N-methanosulphonyl-N-methylamino)-1- (1H-1,2,4-triazol-1-yl)-2-butanol, of formula 1. A procedure is described which is characterized in that the amine 2 (obtained as described in Patent EP 332.387) is reacted with methanosulphonyl chloride in the presence of a base such as triethylamine within a suitable solvent such as chloroform or dichloromethane. Said compound has antifungal activity.
ES9201562A 1992-07-15 1992-07-15 PROCEDURE FOR OBTAINING (-) - (2R, 3R) -2- (2,4-DICLOROFENIL) -3- (N-METANOSULFONIL-N-METHYLAMINE) -1- (1H-1,2,4-TRIAZOL- 1-IL) -2-BUTANOL. Expired - Fee Related ES2051226B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9201562A ES2051226B1 (en) 1992-07-15 1992-07-15 PROCEDURE FOR OBTAINING (-) - (2R, 3R) -2- (2,4-DICLOROFENIL) -3- (N-METANOSULFONIL-N-METHYLAMINE) -1- (1H-1,2,4-TRIAZOL- 1-IL) -2-BUTANOL.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201562A ES2051226B1 (en) 1992-07-15 1992-07-15 PROCEDURE FOR OBTAINING (-) - (2R, 3R) -2- (2,4-DICLOROFENIL) -3- (N-METANOSULFONIL-N-METHYLAMINE) -1- (1H-1,2,4-TRIAZOL- 1-IL) -2-BUTANOL.

Publications (2)

Publication Number Publication Date
ES2051226A1 true ES2051226A1 (en) 1994-06-01
ES2051226B1 ES2051226B1 (en) 1994-12-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201562A Expired - Fee Related ES2051226B1 (en) 1992-07-15 1992-07-15 PROCEDURE FOR OBTAINING (-) - (2R, 3R) -2- (2,4-DICLOROFENIL) -3- (N-METANOSULFONIL-N-METHYLAMINE) -1- (1H-1,2,4-TRIAZOL- 1-IL) -2-BUTANOL.

Country Status (1)

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ES (1) ES2051226B1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0332387A1 (en) * 1988-03-04 1989-09-13 Sankyo Company Limited Triazole derivatives, their preparation and their use as fungicides
EP0480215A1 (en) * 1990-10-08 1992-04-15 J. URIACH & CIA. S.A. New sulfonamides as antifungal agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0332387A1 (en) * 1988-03-04 1989-09-13 Sankyo Company Limited Triazole derivatives, their preparation and their use as fungicides
EP0480215A1 (en) * 1990-10-08 1992-04-15 J. URIACH & CIA. S.A. New sulfonamides as antifungal agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL PHARMACEUTICAL BULLETIN, 39 (10), p. 2581-2589, 1991, OIDA et al.: "Triazole Antifungals. IV. Synthesis and Antifungal activities of 3-Acylamino-2-aryl-2-butanol Derivatives", Pharmaceutical Society of Japan, 1991. *

Also Published As

Publication number Publication date
ES2051226B1 (en) 1994-12-16

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Effective date: 20001009