ES2043882T3 - Utilizacion de un reactivo de epoxidacion, asi como procedimiento para la preparacion de 5 alfa(10 alfa)-epoxi-delta-9,11-esteroides. - Google Patents

Utilizacion de un reactivo de epoxidacion, asi como procedimiento para la preparacion de 5 alfa(10 alfa)-epoxi-delta-9,11-esteroides.

Info

Publication number
ES2043882T3
ES2043882T3 ES88730149T ES88730149T ES2043882T3 ES 2043882 T3 ES2043882 T3 ES 2043882T3 ES 88730149 T ES88730149 T ES 88730149T ES 88730149 T ES88730149 T ES 88730149T ES 2043882 T3 ES2043882 T3 ES 2043882T3
Authority
ES
Spain
Prior art keywords
alpha
aryl
alkyl
steroids
delta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88730149T
Other languages
English (en)
Inventor
Klaus Dr Nickisch
Hanfried Dr Arnold
Ralph Dr Rohde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2043882T3 publication Critical patent/ES2043882T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Abstract

SE DESCRIBE UN NUEVO REACTIVO DE EPOXIDACION CONSISTENTE EN PEROXIDO DE HIDROGENO Y AL MENOS UNA ARILMETILCETONA DE LA FORMULA (I9 DONDE X ES UN ATOMO DE FLUOR O DE CLORO, R1, R2, R3 QUE PUEDEN SER IGUALES O DIFERENTES SIGNIFICAN C1-C6 ALQUILO, C6-C10 ARILO, C6-C10-ALQUILO O-C1-C6-ALQUILO O-C6-C10 ARILO, UN ATOMO DE FLUOR, CLORO, BROMO O HIDROGENO, UN GRUPO CIANO, NITRO O TRIFLUORMETILO, UN RESTO AMIDA -CO-NR4R5 O UN RESTO SULFONILO, -SO2R4, DONDE R4 Y R5 SON IGUALES O DIFERENTES Y SIGNIFICAN UN C1-C6ALQUILO, C1-C10-ARILO O UN C6-C10-ARILO, C1-C6-ALQUILO, DONDE EN EL CASO DE -CO-NR4R5, R4 Y R5 JUNTOS PUEDEN FORMAR UN HETEROCICLO ALIFATICO O AROMATICO DE 5 O 6 MIEMBROS Y R1 Y R2 SON UN ANILLO ALIFATICO O AROMATICO Y SU APLICACION A LA EPOXIDACION DE COMPUESTOS ORGANICOS.
ES88730149T 1987-07-03 1988-07-01 Utilizacion de un reactivo de epoxidacion, asi como procedimiento para la preparacion de 5 alfa(10 alfa)-epoxi-delta-9,11-esteroides. Expired - Lifetime ES2043882T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873722486 DE3722486A1 (de) 1987-07-03 1987-07-03 Neues epoxidierungs-reagenz und seine verwendung

Publications (1)

Publication Number Publication Date
ES2043882T3 true ES2043882T3 (es) 1994-01-01

Family

ID=6331098

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88730149T Expired - Lifetime ES2043882T3 (es) 1987-07-03 1988-07-01 Utilizacion de un reactivo de epoxidacion, asi como procedimiento para la preparacion de 5 alfa(10 alfa)-epoxi-delta-9,11-esteroides.

Country Status (5)

Country Link
EP (1) EP0298020B1 (es)
AT (1) ATE77622T1 (es)
DE (2) DE3722486A1 (es)
ES (1) ES2043882T3 (es)
GR (1) GR3005043T3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120876A (en) * 1989-11-29 1992-06-09 E. I. Du Pont De Nemours And Company Fluorinated sulfones/ketones for nonlinear optics
US6673784B1 (en) * 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
HU228636B1 (en) * 2007-06-27 2013-04-29 Richter Gedeon Nyrt Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
WO2012106514A2 (en) 2011-02-03 2012-08-09 Pop Test Cortisol Llc System and method for diagnosis and treatment
EP2712317B1 (en) 2011-03-31 2018-09-19 Pop Test Oncology LLC Prevention of infection
US8986677B2 (en) 2012-07-30 2015-03-24 Pop Test Cortisol Llc Therapeutic compositions and methods
US9878138B2 (en) 2014-06-03 2018-01-30 Pop Test Abuse Deterrent Technology Llc Drug device configured for wireless communication
CN107848922A (zh) 2015-05-08 2018-03-27 巴斯夫农业公司 柠檬烯‑4‑醇的制备方法
KR20180003570A (ko) * 2015-05-08 2018-01-09 바스프 아그로 비.브이. 테르피놀렌 에폭시드의 제조 방법
EP3472139B1 (en) 2016-06-15 2021-04-07 BASF Agro B.V. Process for the epoxidation of a tetrasubstituted alkene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787169A (nl) * 1971-08-13 1973-02-05 Shell Int Research Werkwijze voor het epoxyderen van olefinen met waterstofperoxyde
FR2423486A1 (fr) * 1978-04-19 1979-11-16 Roussel Uclaf Nouveau reactif d'epoxydation
US4344887A (en) * 1979-12-28 1982-08-17 General Electric Company Method for epoxidizing olefins

Also Published As

Publication number Publication date
ATE77622T1 (de) 1992-07-15
DE3722486A1 (de) 1989-01-12
GR3005043T3 (es) 1993-05-24
EP0298020B1 (de) 1992-06-24
EP0298020A1 (de) 1989-01-04
DE3872317D1 (de) 1992-07-30

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