ES2041597B1 - NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. - Google Patents
NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS.Info
- Publication number
- ES2041597B1 ES2041597B1 ES9200931A ES9200931A ES2041597B1 ES 2041597 B1 ES2041597 B1 ES 2041597B1 ES 9200931 A ES9200931 A ES 9200931A ES 9200931 A ES9200931 A ES 9200931A ES 2041597 B1 ES2041597 B1 ES 2041597B1
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- organic solvent
- capsulate
- pharmaceutical
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
NUEVO PROCEDIMIENTO PARA LA PREPARACION DE LIPOSOMAS QUE ENCAPSULAN PRODUCTOS FARMACEUTICOS Y COSMETICOS. COMPRENDE: A) PREPARAR UNA SOLUCION DEL LIPIDO FORMADOR DE LIPOSOMAS EN UN DISOLVENTE ORGANICO, QUE PUEDE CONTENER DISUELTO EL O LOS INGREDIENTES ACTIVOS; B) EVAPORAR EL DISOLVENTE ORGANICO A SEQUEDAD QUEDANDO UNA MATRIZ QUE CONTIENE EL PRINCIPIO ACTIVO A ENCAPSULAR; C) AÑADIR A LA MATRIZ LIPIDICA ANTERIOR UN DISOLVENTE ORGANICO, PARA SU HOMOGENEIZACION; D) EN EL CASO DE QUE EL(LOS) INGREDIENTE(S) ACTIVO(S) NO PUEDA(N) DISOLVERSE EN EL DISOLVENTE ORGANICO, DISOLVERLO(S) EN UNA SOLUCION TAMPON ADECUADA; E HOMOGENEIZAR LA MEZCLA HETEROGENEA OBTENIDA EN D) A 8.000-15.000 R.P.M. DURANTE UN PERIODO DE TIEMPO DE 15 MINUTOS, OBTENIENDOSE UNA SUSPENSION LIPOSOMAL CONTENIENDO LIPOSOMAS MULTILAMELARES CON UN TAMAÑO MEDIO DE 250-350 NM Y UNA POLIDISPERSIDAD DE 0.17; E) CON EL FIN DE REDUCIR EL TAMAÑO DE PARTICULA DE LOS LIPOSOMAS, ESTOS PUEDEN SOMETERSE A UN PROCESO DE EXTRUSION. APLICACION EN CLINICA HUMANA, CLINICA VETERINARIA Y COSMETICA.NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. IT UNDERSTANDS: A) PREPARE A LIPOSOM FORMING LIPID SOLUTION IN AN ORGANIC SOLVENT, WHICH MAY CONTAIN SOLVED THE ACTIVE INGREDIENTS OR INGREDIENTS; B) EVAPORATE THE ORGANIC SOLVENT TO DROUGHT REMAINING A MATRIX CONTAINING THE ACTIVE PRINCIPLE TO ENCAPSULATE; C) ADD TO THE PREVIOUS LIPID MATRIX AN ORGANIC SOLVENT FOR HOMOGENIZATION; D) IN THE EVENT THAT THE ACTIVE INGREDIENT (S) CANNOT BE SOLVED IN THE ORGANIC SOLVENT, SOLVE IT (S) IN AN APPROPRIATE BUFFER SOLUTION; E HOMOGENIZE THE HETEROGENOUS MIXTURE OBTAINED IN D) AT 8,000-15,000 R.P.M. DURING A PERIOD OF TIME OF 15 MINUTES, OBTAINING A LIPOSOMAL SUSPENSION CONTAINING MULTILAMEL LIPOSOMES WITH AN AVERAGE SIZE OF 250-350 NM AND A POLYDISPERSITY OF 0.17; E) IN ORDER TO REDUCE THE PARTICULATE SIZE OF THE LIPOSOMES, THESE MAY BE SUBMITTED TO AN EXTRUSION PROCESS. APPLICATION IN HUMAN CLINIC, VETERINARY CLINIC AND COSMETICS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200931A ES2041597B1 (en) | 1992-05-05 | 1992-05-05 | NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9200931A ES2041597B1 (en) | 1992-05-05 | 1992-05-05 | NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2041597A1 ES2041597A1 (en) | 1993-11-16 |
| ES2041597B1 true ES2041597B1 (en) | 1994-06-01 |
Family
ID=8276917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9200931A Expired - Fee Related ES2041597B1 (en) | 1992-05-05 | 1992-05-05 | NEW PROCEDURE FOR THE PREPARATION OF LIPOSOMES THAT CAPSULATE PHARMACEUTICAL AND COSMETIC PRODUCTS. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2041597B1 (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6058915A (en) * | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | Lipid microcapsule preparation containing medicament |
| JPH0753661B2 (en) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | Pro-liposome composition and method of making an aqueous dispersion of liposomes |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| JPH0751496B2 (en) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | Manufacturing method of liposome |
| AU598002B2 (en) * | 1986-07-15 | 1990-06-14 | Cilag Ltd. | Method of preparing single bilayered liposomes |
| GB8704171D0 (en) * | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
| CA2046997C (en) * | 1990-07-16 | 2000-12-12 | Hiroshi Kikuchi | Liposomal products |
| AR244546A1 (en) * | 1990-10-30 | 1993-11-30 | Gador Y Cia S A C I Lab Dr | Procedure for the preparation of liposomes insoluble in oil for in soft completely soluble gelatinous capsules. |
-
1992
- 1992-05-05 ES ES9200931A patent/ES2041597B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2041597A1 (en) | 1993-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20110803 |