ES2038094T1 - Un procedimiento para la preparacion del compuesto 2,6-diamino-9-(2,3,5-trio-o-bencilbeta-d-arabinofuranosil)purina. - Google Patents
Un procedimiento para la preparacion del compuesto 2,6-diamino-9-(2,3,5-trio-o-bencilbeta-d-arabinofuranosil)purina.Info
- Publication number
- ES2038094T1 ES2038094T1 ES199091901479T ES91901479T ES2038094T1 ES 2038094 T1 ES2038094 T1 ES 2038094T1 ES 199091901479 T ES199091901479 T ES 199091901479T ES 91901479 T ES91901479 T ES 91901479T ES 2038094 T1 ES2038094 T1 ES 2038094T1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- purine
- bencilbeta
- arabinofuranosil
- trio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE DESCRIBE UN PROCESO PARA PREPARAR 2, 6-DIAMINO-9-(2, 3, 5-TRI-O-BENCIL -BETA-D-ARABINO-FURANOSIL PURINA (V) HACIENDO REACCIONAR 2, 6-DI (ALCOXIACETAMIDO)PURINA (II) CON 2, 3, 5-TRI-O-BENCIL-1-CLORO-ALFA-D -ARABINOFURANOSA (III) PARA PRODUCIR 2, 6-DI(ALCOXIACETAMIDO)-9-(2, 3, 5 -TRI-O-BENCIL-BETA-D-ARABINOFURANOSIL)PURINA (IV) Y LUEGO DESPROTEGER LAS POSICIONES 2, 6 PARA PRODUCIR LA 2, 6-DIAMINA (V). EL PROCESO PROPORCIONA PURINA (V) EN GRAN CANTIDAD. LA PURINA (V) ES UN INTERMEDIARIO EN LA PREPARACION DE 9-BETA-D-ARABINOFURANOSIL-2-FLUOROADENINA QUE ES UN AGENTE CITOTOXICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/445,446 US5110919A (en) | 1989-12-04 | 1989-12-04 | Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2038094T1 true ES2038094T1 (es) | 1993-07-16 |
ES2038094T3 ES2038094T3 (es) | 1996-06-01 |
Family
ID=23768933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91901479T Expired - Lifetime ES2038094T3 (es) | 1989-12-04 | 1990-11-30 | Procedimiento para la preparacion de 2-amino-9-(2,3,5-tri-o-bencil-beta-d-arabinofuranosil)adenina y nuevos compuestos intermedios. |
Country Status (9)
Country | Link |
---|---|
US (2) | US5110919A (es) |
EP (1) | EP0456817B1 (es) |
JP (2) | JPH07634B2 (es) |
AT (1) | ATE133682T1 (es) |
DE (2) | DE456817T1 (es) |
DK (1) | DK0456817T3 (es) |
ES (1) | ES2038094T3 (es) |
GR (2) | GR920300026T1 (es) |
WO (1) | WO1991008215A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5110919A (en) * | 1989-12-04 | 1992-05-05 | Ash Stevens, Inc. | Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates |
CA2091732C (en) * | 1992-07-08 | 1998-07-21 | Anica Markovac | A process for the preparation of 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine |
US5602246A (en) * | 1992-11-25 | 1997-02-11 | Schering Aktiengesellschaft | Process for the preparation of fludarabine or fludarabine phosphate from guanosine |
WO1999029710A2 (de) * | 1997-12-11 | 1999-06-17 | Schering Aktiengesellschaft | Reinigungsverfahren zur herstellung von fludarabin-phosphat |
ATE332910T1 (de) * | 2000-02-18 | 2006-08-15 | Southern Res Inst | Verfahren zur herstellung von 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofura osyl)-9h-purin-6-amin |
DE10164510A1 (de) * | 2001-12-20 | 2003-07-10 | Schering Ag | Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes |
US7491725B2 (en) | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
EP3342778B1 (en) * | 2015-08-28 | 2022-01-12 | Zhejiang Hisun Pharmaceutical Co., Ltd. | Crystal form of fludarabine phosphat, preparation method therefor, and application thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3008969A (en) * | 1958-05-21 | 1961-11-14 | American Cyanamid Co | 4-substituted-7-carboalkoxyamino-coumarins |
USRE29835E (en) * | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
US4188378A (en) * | 1978-01-04 | 1980-02-12 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine |
US5110919A (en) * | 1989-12-04 | 1992-05-05 | Ash Stevens, Inc. | Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates |
-
1989
- 1989-12-04 US US07/445,446 patent/US5110919A/en not_active Expired - Lifetime
-
1990
- 1990-11-30 ES ES91901479T patent/ES2038094T3/es not_active Expired - Lifetime
- 1990-11-30 EP EP91901479A patent/EP0456817B1/en not_active Expired - Lifetime
- 1990-11-30 DE DE199191901479T patent/DE456817T1/de active Pending
- 1990-11-30 JP JP3501945A patent/JPH07634B2/ja not_active Expired - Fee Related
- 1990-11-30 DE DE69025176T patent/DE69025176T2/de not_active Expired - Fee Related
- 1990-11-30 DK DK91901479.5T patent/DK0456817T3/da active
- 1990-11-30 AT AT91901479T patent/ATE133682T1/de not_active IP Right Cessation
- 1990-11-30 WO PCT/US1990/007004 patent/WO1991008215A1/en active IP Right Grant
-
1992
- 1992-04-30 US US07/876,412 patent/US5296589A/en not_active Expired - Fee Related
- 1992-08-26 GR GR92300026T patent/GR920300026T1/el unknown
-
1994
- 1994-06-30 JP JP6149934A patent/JPH07108912B2/ja not_active Expired - Fee Related
-
1996
- 1996-04-16 GR GR960401037T patent/GR3019656T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH07108912B2 (ja) | 1995-11-22 |
US5110919A (en) | 1992-05-05 |
WO1991008215A1 (en) | 1991-06-13 |
EP0456817A1 (en) | 1991-11-21 |
US5296589A (en) | 1994-03-22 |
EP0456817A4 (en) | 1992-04-22 |
GR920300026T1 (en) | 1992-08-26 |
DE69025176T2 (de) | 1996-05-30 |
ES2038094T3 (es) | 1996-06-01 |
DK0456817T3 (da) | 1996-04-29 |
DE456817T1 (de) | 1992-04-09 |
JPH07634B2 (ja) | 1995-01-11 |
JPH07138280A (ja) | 1995-05-30 |
DE69025176D1 (de) | 1996-03-14 |
GR3019656T3 (en) | 1996-07-31 |
EP0456817B1 (en) | 1996-01-31 |
ATE133682T1 (de) | 1996-02-15 |
JPH04504268A (ja) | 1992-07-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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