ES2036464A1 - Prepn. of O-(2,6-di:chloro:aniline)phenylacetic acid sodium salt - Google Patents
Prepn. of O-(2,6-di:chloro:aniline)phenylacetic acid sodium saltInfo
- Publication number
- ES2036464A1 ES2036464A1 ES919101844A ES9101844A ES2036464A1 ES 2036464 A1 ES2036464 A1 ES 2036464A1 ES 919101844 A ES919101844 A ES 919101844A ES 9101844 A ES9101844 A ES 9101844A ES 2036464 A1 ES2036464 A1 ES 2036464A1
- Authority
- ES
- Spain
- Prior art keywords
- prepn
- give
- sodium salt
- acid sodium
- phenylacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prepn. of O-(2,6-dichloroaniline)- phenylacetic acid sodium salt (I) comprises reacting 2,6-dichloroaniline with bromobenzene in xylene in the presence of K2CO3, cuprous chloride and a catalyst to give 2,6-dichlorodiphenylamine, which is acylated with chloroacetylchloride to give N-(chloroacetyl)-2,6-dichloro-diphenylamine, which is treated with anhydrous AlCl3 to give 1-(2,6-dichlorophenyl)- 2-indolinone, which is hydrolysed with NaOH in a mixt. of boiling water and alcohol such as MeOH, EtOH or iPrOH to give (I).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101844A ES2036464B1 (en) | 1991-08-07 | 1991-08-07 | INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE. |
MX9204026A MX9204026A (en) | 1991-08-07 | 1992-07-09 | INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIC SALT FROM A FENILE ACETIC DERIVATIVE. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101844A ES2036464B1 (en) | 1991-08-07 | 1991-08-07 | INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2036464A1 true ES2036464A1 (en) | 1993-05-16 |
ES2036464B1 ES2036464B1 (en) | 1993-12-16 |
Family
ID=8273255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9101844A Expired - Lifetime ES2036464B1 (en) | 1991-08-07 | 1991-08-07 | INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE. |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES2036464B1 (en) |
MX (1) | MX9204026A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109956894A (en) * | 2019-04-28 | 2019-07-02 | 南昌航空大学 | A kind of synthetic method of 3,3 '-two substitution -2- indole ketone compounds |
CN111116391A (en) * | 2019-12-17 | 2020-05-08 | 浙江工业大学 | Preparation method of sodium 2- [ (2, 6-dichlorophenyl) amino ] phenylacetate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES345833A1 (en) * | 1966-10-07 | 1968-11-16 | Geigy Ag J R | Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) |
US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
NL7801523A (en) * | 1977-02-09 | 1978-08-11 | Ikeda Mohando Co | PROCESS FOR PREPARING O- (2,6-DICHLORANILINO) -PHENYLAIC ACID AND ITS ACID ADDITIONAL SALTS. |
DD134520A1 (en) * | 1977-12-30 | 1979-03-07 | Ernst Tenor | PROCESS FOR PREPARING 1- (2,6-DICHLORPHENYL) -INDOLINONE- (2) |
-
1991
- 1991-08-07 ES ES9101844A patent/ES2036464B1/en not_active Expired - Lifetime
-
1992
- 1992-07-09 MX MX9204026A patent/MX9204026A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
ES345833A1 (en) * | 1966-10-07 | 1968-11-16 | Geigy Ag J R | Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding) |
NL7801523A (en) * | 1977-02-09 | 1978-08-11 | Ikeda Mohando Co | PROCESS FOR PREPARING O- (2,6-DICHLORANILINO) -PHENYLAIC ACID AND ITS ACID ADDITIONAL SALTS. |
DD134520A1 (en) * | 1977-12-30 | 1979-03-07 | Ernst Tenor | PROCESS FOR PREPARING 1- (2,6-DICHLORPHENYL) -INDOLINONE- (2) |
Non-Patent Citations (2)
Title |
---|
BASE DE DATOS WPI, 78-61579A, 78, DERWENT Publ. Ltd. LONDON, GB & NL-A-7801523 (IKEDA MOHANDO KK), 11-Agosto-78 * Resumen * * |
BASE DE DATOS WPI, 79-39059B, 79, DERWENT Publ. Ltd. LONDON, GB & DD-A-134520 (TENOR, E.), 7-Marzo-79 * Resumen * * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109956894A (en) * | 2019-04-28 | 2019-07-02 | 南昌航空大学 | A kind of synthetic method of 3,3 '-two substitution -2- indole ketone compounds |
CN109956894B (en) * | 2019-04-28 | 2022-04-15 | 南昌航空大学 | Synthetic method of 3, 3' -disubstituted-2-indolone compound |
CN111116391A (en) * | 2019-12-17 | 2020-05-08 | 浙江工业大学 | Preparation method of sodium 2- [ (2, 6-dichlorophenyl) amino ] phenylacetate |
Also Published As
Publication number | Publication date |
---|---|
MX9204026A (en) | 1992-11-01 |
ES2036464B1 (en) | 1993-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA2A | Application withdrawn |
Effective date: 19940516 |