ES2036464A1 - Prepn. of O-(2,6-di:chloro:aniline)phenylacetic acid sodium salt - Google Patents

Prepn. of O-(2,6-di:chloro:aniline)phenylacetic acid sodium salt

Info

Publication number
ES2036464A1
ES2036464A1 ES919101844A ES9101844A ES2036464A1 ES 2036464 A1 ES2036464 A1 ES 2036464A1 ES 919101844 A ES919101844 A ES 919101844A ES 9101844 A ES9101844 A ES 9101844A ES 2036464 A1 ES2036464 A1 ES 2036464A1
Authority
ES
Spain
Prior art keywords
prepn
give
sodium salt
acid sodium
phenylacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES919101844A
Other languages
Spanish (es)
Other versions
ES2036464B1 (en
Inventor
Torres Salvador Puig
Baro Niquel Ribalta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Quimica SA
Original Assignee
Esteve Quimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica SA filed Critical Esteve Quimica SA
Priority to ES9101844A priority Critical patent/ES2036464B1/en
Priority to MX9204026A priority patent/MX9204026A/en
Publication of ES2036464A1 publication Critical patent/ES2036464A1/en
Application granted granted Critical
Publication of ES2036464B1 publication Critical patent/ES2036464B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Prepn. of O-(2,6-dichloroaniline)- phenylacetic acid sodium salt (I) comprises reacting 2,6-dichloroaniline with bromobenzene in xylene in the presence of K2CO3, cuprous chloride and a catalyst to give 2,6-dichlorodiphenylamine, which is acylated with chloroacetylchloride to give N-(chloroacetyl)-2,6-dichloro-diphenylamine, which is treated with anhydrous AlCl3 to give 1-(2,6-dichlorophenyl)- 2-indolinone, which is hydrolysed with NaOH in a mixt. of boiling water and alcohol such as MeOH, EtOH or iPrOH to give (I).
ES9101844A 1991-08-07 1991-08-07 INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE. Expired - Lifetime ES2036464B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES9101844A ES2036464B1 (en) 1991-08-07 1991-08-07 INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE.
MX9204026A MX9204026A (en) 1991-08-07 1992-07-09 INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIC SALT FROM A FENILE ACETIC DERIVATIVE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9101844A ES2036464B1 (en) 1991-08-07 1991-08-07 INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE.

Publications (2)

Publication Number Publication Date
ES2036464A1 true ES2036464A1 (en) 1993-05-16
ES2036464B1 ES2036464B1 (en) 1993-12-16

Family

ID=8273255

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101844A Expired - Lifetime ES2036464B1 (en) 1991-08-07 1991-08-07 INDUSTRIAL PROCEDURE FOR THE OBTAINING OF SODIUM SALT FROM A PHENYLACETIC DERIVATIVE.

Country Status (2)

Country Link
ES (1) ES2036464B1 (en)
MX (1) MX9204026A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109956894A (en) * 2019-04-28 2019-07-02 南昌航空大学 A kind of synthetic method of 3,3 '-two substitution -2- indole ketone compounds
CN111116391A (en) * 2019-12-17 2020-05-08 浙江工业大学 Preparation method of sodium 2- [ (2, 6-dichlorophenyl) amino ] phenylacetate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES345833A1 (en) * 1966-10-07 1968-11-16 Geigy Ag J R Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding)
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
NL7801523A (en) * 1977-02-09 1978-08-11 Ikeda Mohando Co PROCESS FOR PREPARING O- (2,6-DICHLORANILINO) -PHENYLAIC ACID AND ITS ACID ADDITIONAL SALTS.
DD134520A1 (en) * 1977-12-30 1979-03-07 Ernst Tenor PROCESS FOR PREPARING 1- (2,6-DICHLORPHENYL) -INDOLINONE- (2)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
ES345833A1 (en) * 1966-10-07 1968-11-16 Geigy Ag J R Procedure for the preparation of new substitute phenylacetic acids. (Machine-translation by Google Translate, not legally binding)
NL7801523A (en) * 1977-02-09 1978-08-11 Ikeda Mohando Co PROCESS FOR PREPARING O- (2,6-DICHLORANILINO) -PHENYLAIC ACID AND ITS ACID ADDITIONAL SALTS.
DD134520A1 (en) * 1977-12-30 1979-03-07 Ernst Tenor PROCESS FOR PREPARING 1- (2,6-DICHLORPHENYL) -INDOLINONE- (2)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BASE DE DATOS WPI, 78-61579A, 78, DERWENT Publ. Ltd. LONDON, GB & NL-A-7801523 (IKEDA MOHANDO KK), 11-Agosto-78 * Resumen * *
BASE DE DATOS WPI, 79-39059B, 79, DERWENT Publ. Ltd. LONDON, GB & DD-A-134520 (TENOR, E.), 7-Marzo-79 * Resumen * *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109956894A (en) * 2019-04-28 2019-07-02 南昌航空大学 A kind of synthetic method of 3,3 '-two substitution -2- indole ketone compounds
CN109956894B (en) * 2019-04-28 2022-04-15 南昌航空大学 Synthetic method of 3, 3' -disubstituted-2-indolone compound
CN111116391A (en) * 2019-12-17 2020-05-08 浙江工业大学 Preparation method of sodium 2- [ (2, 6-dichlorophenyl) amino ] phenylacetate

Also Published As

Publication number Publication date
MX9204026A (en) 1992-11-01
ES2036464B1 (en) 1993-12-16

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Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19940516