ES2033581B1 - PROCEDURE FOR OBTAINING NEW TETRALONAS. - Google Patents

PROCEDURE FOR OBTAINING NEW TETRALONAS.

Info

Publication number
ES2033581B1
ES2033581B1 ES9101777A ES9101777A ES2033581B1 ES 2033581 B1 ES2033581 B1 ES 2033581B1 ES 9101777 A ES9101777 A ES 9101777A ES 9101777 A ES9101777 A ES 9101777A ES 2033581 B1 ES2033581 B1 ES 2033581B1
Authority
ES
Spain
Prior art keywords
csi1
alkyl
csi2
oxo
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9101777A
Other languages
Spanish (es)
Other versions
ES2033581A1 (en
Inventor
Carmen Almansa
Conception Gonzalez
M Carmen Torres
Elena Carceller
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES9101777A priority Critical patent/ES2033581B1/en
Priority to CA002074864A priority patent/CA2074864A1/en
Priority to JP4223193A priority patent/JPH0640994A/en
Priority to EP92113007A priority patent/EP0525768A1/en
Publication of ES2033581A1 publication Critical patent/ES2033581A1/en
Application granted granted Critical
Publication of ES2033581B1 publication Critical patent/ES2033581B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE TETRALONAS DE FORMULA GENERAL I, UTILES COMO REGULADORES DE LA CONTRACCION DE LA MUSCULATURA LISA EN LOS SISTEMAS CARDIOVASCULAR, BRONCOPULMONAR Y DIGESTIVO; EN DONDE RBS1 Y RBS2 SIGNIFICAN HIDROGENO, CIANO, NITRO, HALOGENO, HIDROXI O CSI1-4 ALCOXI; RBS3 ES HIDROGENO O CSI1-4 ALQUILO; RBS4 ES CSI1-4 ALQUILO, O BIEN RBS3 Y RBS4 JUNTOS FORMAN UNA CADENA DE CSI2-5 POLIMETILENO; RBS5 ES UN GRUPO HIDROXILO O ACETILOXI Y RBS6 ES HIDROGENO, O BIEN RBS5 Y RBS6 JUNTOS FORMAN UN DOBLE ENLACE; RBS7 ES UN GRUPO PIRIDILO, PIRIDAZINILO, PIRIMIDINILO, PIRAZINILO, OXO-DIHIDROPIRIDILO, OXO-DIHIDROPIRIDAZINILO, OXO-DIHIDROPIRIMIDINILO, OXO-DIHIDROPIRAZINILO, OPCIONALMENTE SUSTITUIDOS POR UNO O DOS GRUPOS RBS8; RBS8 ES UN ATOMO DE HALOGENO, UN GRUPO CSI1-4 ALQUILO, CSI2-4 ALQUENILMETILO, CSI2-4 ALQUINILMETILO, HIDROXILO, CSI1-4 ALCOXI, CSI1-4 TIOALCOXI, CSI1-4 ALQUILCARBONILOXI, CSI1-4ALQUILCARBONILO, CSI1-4 ALQUILTIOCARBONILO, CSI1-4 ALCOXICARBONILO, NITRO, AMINO OPCIONALMENTE SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO, CSI1-4 ALQUILCARBONILAMINO, CARBOXILO, TIOL, CIANO, TRIFLUOROMETILO O ARILO; CARACTERIZADO PORQUE SE HACE REACCIONAR LA CORRESPONDIENTE 3,4-EPOXITETRALONA CON UN COMPUESTO DE FORMULA RBS7-OH EN PRESENCIA DE UNA BASE COMO LA PIRIDINA EN UN DISOLVENTE ADECUADO COMO EL ETANOL.PROCEDURE FOR THE OBTAINING OF TETRALONES OF GENERAL FORMULA I, USEFUL AS REGULATORS OF THE CONTRACTION OF THE SMOOTH MUSCULATURE IN THE CARDIOVASCULAR, BRONCOPULMONARY AND DIGESTIVE SYSTEMS; WHERE RBS1 AND RBS2 MEAN HYDROGEN, CYAN, NITRO, HALOGEN, HYDROXY OR CSI1-4 ALCOXI; RBS3 IS HYDROGEN OR CSI1-4 ALKYL; RBS4 IS CSI1-4 ALKYL, OR RBS3 AND RBS4 TOGETHER FORM A CHAIN OF CSI2-5 POLYMETHYLENE; RBS5 IS A HYDROXYL OR ACETYLLOX GROUP AND RBS6 IS HYDROGEN, OR RBS5 AND RBS6 TOGETHER FORM A DOUBLE LINK; RBS7 IS A GROUP OF PIRIDYL, PIRIDAZINYL, PIRIMIDINYL, PIRAZINYL, OXO-DIHIDROPIRIDAZINYL, OXO-DIHYDROPYRIMIDINYL, OXO-DIHIDROPIRAZINOS, OPX RBS8 IS A HALOGEN ATOM, A GROUP CSI1-4 ALKYL, CSI2-4 ALKENYLMETHYL, CSI2-4 ALKYNYLMETHYL, HYDROXYL, CSI1-4 ALCOXY, CSI1-4 THIOALCOXYL, CSI1-4 ALKYL CARBONYLX, CSI1-4 CSI1-4 ALCOXICARBONILO, NITRO, AMINO OPTIONALLY REPLACED BY ONE OR TWO ALKYL GROUPS, CSI1-4 ALQUILCARBONILAMINO, CARBOXILO, TIOL, CIANO, TRIFLUOROMETILO OR ARILO; CHARACTERIZED BECAUSE THE CORRESPONDING 3,4-EPOXYETHRALONE IS REACTED WITH A COMPOUND OF FORMULA RBS7-OH IN THE PRESENCE OF A BASE LIKE PYRIDINE IN A SUITABLE SOLVENT LIKE ETHANOL.

ES9101777A 1991-07-30 1991-07-30 PROCEDURE FOR OBTAINING NEW TETRALONAS. Expired - Fee Related ES2033581B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES9101777A ES2033581B1 (en) 1991-07-30 1991-07-30 PROCEDURE FOR OBTAINING NEW TETRALONAS.
CA002074864A CA2074864A1 (en) 1991-07-30 1992-07-29 Tetralones with pharmacological activity
JP4223193A JPH0640994A (en) 1991-07-30 1992-07-30 New tetralone with pharmaceutical activity
EP92113007A EP0525768A1 (en) 1991-07-30 1992-07-30 Tetralones with pharmacological activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9101777A ES2033581B1 (en) 1991-07-30 1991-07-30 PROCEDURE FOR OBTAINING NEW TETRALONAS.

Publications (2)

Publication Number Publication Date
ES2033581A1 ES2033581A1 (en) 1993-03-16
ES2033581B1 true ES2033581B1 (en) 1993-12-16

Family

ID=8273171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9101777A Expired - Fee Related ES2033581B1 (en) 1991-07-30 1991-07-30 PROCEDURE FOR OBTAINING NEW TETRALONAS.

Country Status (1)

Country Link
ES (1) ES2033581B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0641454B2 (en) * 1985-02-27 1994-06-01 日産化学工業株式会社 Pyridazinone derivative
DK196688A (en) * 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co BICYCLIC RELATIONS AND PROCEDURES FOR PRODUCING THEREOF

Also Published As

Publication number Publication date
ES2033581A1 (en) 1993-03-16

Similar Documents

Publication Publication Date Title
ES2055056T3 (en) DERIVATIVES OF PIRIMIDOPIRIMIDINA.
CO4950558A1 (en) AMINO ACID RECEPTOR MODULATORS EXCITORS
DE69839887D1 (en) CONDENSED PYRIDINE DERIVATIVES
DK0495053T3 (en) New links to bioactive agents
ES2061077T3 (en) METHOD FOR PRODUCING AN INTERMEDIATE PRODUCT FOR THE PREPARATION OF DRUGS.
ES557198A0 (en) A PROCEDURE FOR THE PREPARATION OF NEW CYCLOPENTA (D) PIRIMIDINE DERIVATIVES
NO954692D0 (en) Substituted beta-aryl and beta-heteroaryl-alpha-cyanoacrylamide derivatives as tyrosine kinase inhibitors
ES2058177T3 (en) NEW DERIVATIVES OF ALCANOSULFONANILIDA, PROCEDURES FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
ES2043863T3 (en) PROCEDURE FOR PREPARING 1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES.
ES2033581B1 (en) PROCEDURE FOR OBTAINING NEW TETRALONAS.
ES2151991T3 (en) PROCEDURE TO PREPARE A TENAN DERIVATIVE (2,3-B) (1,5) BENZODIACEPIN.
ES2073393T3 (en) DERIVATIVES OF ACIDES 2,4- AND 2,5-DICARBOXILICOS, PROCEDURE FOR ITS PREPARATION, USE OF THE SAME AS WELL AS MEDICINES BASED ON THESE COMPOUNDS.
DE50101861D1 (en) TOCOTRIENOLCHINONE CYCLIZING PRODUCTS WITH ANTIHYPERCHOLESTERINE EFFECT
GT199900113A (en) FKBP INHIBITORS.
ES2029879T3 (en) PROCEDURE FOR PRODUCING SUBSTITUTED AMINE DERIVATIVES.
ATE133162T1 (en) A SYNTHESIS METHOD FOR PROSTAGLAND DERIVATIVES
DK0463944T3 (en) New Acylbenzoxazolinones, Methods of Preparation and Pharmaceuticals Containing Them
ES2074343T3 (en) NEW PHENYLETHANOLAMINE- AND PHENYLETHANOLAMINOMETHYL-TETRALINES, PROCEDURE FOR ITS PREPARATION, INTERMEDIARIES IN THIS PROCEDURE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
CO4650030A1 (en) DERIVATIVES OF N- (BENZOTIAZOL-2-IL) PIPERIDINE-1-ETHANAMINE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL PRODUCT CONTAINING THEM
CO5080758A1 (en) DERIVATIVES OF 3- (2-oxo- [1,3´] BIPIRROLODINIL-3-ILIDENMETIL
ES2064228B1 (en) NEW TETRALONES WITH PHARMACOLOGICAL ACTIVITY, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE FOR THEIR PREPARATION.
ES2183786T3 (en) 1,2,3,4,5,6-HEXAHYDRO-2,6-METHANE-3-BENZAZOCIN-10-SUBSTITUTED WAVES, PROCEDURE FOR PREPARATION AND USE AS A MEDICINAL PRODUCT.
KR830002680A (en) Method for preparing 1- (aminoalkylamino) -5,8-dihydroxy-1-substituted anthraquinone compound
DK153547C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF AMINOAL COXYPYRAZOLES OR SALTS THEREOF
MX9302313A (en) PROCEDURE FOR THE OBTAINING OF HEXAFLUORCHLOROBUTENES.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009