ES2021182A6 - Capsaicin derivatives - Google Patents

Capsaicin derivatives

Info

Publication number
ES2021182A6
ES2021182A6 ES8904323A ES8904323A ES2021182A6 ES 2021182 A6 ES2021182 A6 ES 2021182A6 ES 8904323 A ES8904323 A ES 8904323A ES 8904323 A ES8904323 A ES 8904323A ES 2021182 A6 ES2021182 A6 ES 2021182A6
Authority
ES
Spain
Prior art keywords
capsaicin derivatives
capsaicin
derivatives
analgesics
formulae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8904323A
Other languages
Spanish (es)
Inventor
Derek J Reid
Christopher S J Walpole
Roger Wrigglesworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888830143A external-priority patent/GB8830143D0/en
Priority claimed from GB898922440A external-priority patent/GB8922440D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2021182A6 publication Critical patent/ES2021182A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings

Abstract

Capsaicin derivatives of general formula I < IMAGE > wherein R is O, S or NH, R1 to R7 may be a variety of substituents, and X is acyclic hydrocarbon, are useful as pharmaceuticals, in particular as analgesics and anti-inflammatory agents. Precursors of the above compounds are of the formulae X, VIII, V, II and III:-
ES8904323A 1988-12-23 1989-12-21 Capsaicin derivatives Expired - Lifetime ES2021182A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888830143A GB8830143D0 (en) 1988-12-23 1988-12-23 Improvements in or relating to organic compounds
GB898922440A GB8922440D0 (en) 1989-10-05 1989-10-05 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
ES2021182A6 true ES2021182A6 (en) 1991-10-16

Family

ID=26294772

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8904323A Expired - Lifetime ES2021182A6 (en) 1988-12-23 1989-12-21 Capsaicin derivatives

Country Status (23)

Country Link
JP (1) JPH0764803B2 (en)
AT (1) AT397797B (en)
AU (1) AU628902B2 (en)
BE (1) BE1003848A3 (en)
CA (1) CA2006115A1 (en)
CH (1) CH678621A5 (en)
DE (1) DE3942729A1 (en)
DK (1) DK657089A (en)
ES (1) ES2021182A6 (en)
FI (1) FI896192A0 (en)
FR (1) FR2640971B1 (en)
GB (1) GB2226313B (en)
GR (1) GR1000460B (en)
HU (1) HU206082B (en)
IE (1) IE59336B1 (en)
IL (1) IL92830A (en)
IT (1) IT1237479B (en)
LU (1) LU87648A1 (en)
NL (1) NL8903132A (en)
NZ (1) NZ231965A (en)
PH (1) PH27571A (en)
PT (1) PT92674A (en)
SE (1) SE8904306L (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058492T3 (en) * 1988-02-03 1994-11-01 Hybritech Inc IMPROVEMENTS IN OR RELATIVE TO MODIFIED HAPTENES USEFUL AS THERAPEUTIC AND IMAGE FORMATION AGENTS.
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
GB9711962D0 (en) * 1997-06-10 1997-08-06 Reckitt & Colmann Prod Ltd Therapeutically active compositions
DE10019670A1 (en) * 2000-04-19 2001-10-31 Diego Palermo Medicament containing red pepper constituents useful as a dermatological agent, especially for treatment of damaged skin
EP1303483B1 (en) * 2000-08-21 2008-04-23 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
TWI283665B (en) 2001-09-13 2007-07-11 Smithkline Beecham Plc Novel urea compound, pharmaceutical composition containing the same and its use
DE60325025D1 (en) 2002-02-15 2009-01-15 Glaxo Group Ltd MODULATORS OF THE VANILLOID RECEPTOR
GB0319150D0 (en) 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
AT413646B (en) * 2004-04-02 2006-04-15 Hammer Johann Dr USE OF CAPSAICIN AND / OR CAPSAICINOIDES
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
US8754101B2 (en) 2011-04-11 2014-06-17 Glaxo Group Limited N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists
CN111647537B (en) * 2020-06-18 2022-04-26 浙江工业大学 Salt-tolerant capsaicin degrading bacteria, application and kitchen waste treatment method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU795462A3 (en) * 1975-03-14 1981-01-07 Эдьт Дьедьесерведьесети Дьяр (Фирма) Method of preparing thiocarbamide derivatives
ES474449A1 (en) * 1978-10-23 1979-05-01 Invest Tecnica Aplicada Anti-ulcer compositions
US4460602A (en) * 1981-06-30 1984-07-17 The Procter & Gamble Company Urea derivatives
EP0282127B1 (en) * 1987-03-09 1994-02-02 The Procter & Gamble Company Beta-aminoethyl-substituted phenyl compounds, and anti-inflammatory or analgesic compositions containing them
GB8715357D0 (en) * 1987-06-30 1987-08-05 Sandoz Inst For Medical Resear Organic compounds

Also Published As

Publication number Publication date
PT92674A (en) 1990-06-29
HU896479D0 (en) 1990-02-28
IT8948682A0 (en) 1989-12-21
LU87648A1 (en) 1991-09-18
CH678621A5 (en) 1991-10-15
NZ231965A (en) 1992-09-25
AT397797B (en) 1994-06-27
SE8904306D0 (en) 1989-12-21
HU206082B (en) 1992-08-28
FI896192A0 (en) 1989-12-21
HUT56342A (en) 1991-08-28
BE1003848A3 (en) 1992-06-30
DK657089A (en) 1990-06-24
AU628902B2 (en) 1992-09-24
AU4717089A (en) 1990-06-28
FR2640971A1 (en) 1990-06-29
SE8904306L (en) 1991-06-22
GB2226313B (en) 1992-06-03
JPH0764803B2 (en) 1995-07-12
GB8928581D0 (en) 1990-02-21
IT1237479B (en) 1993-06-07
DE3942729A1 (en) 1990-07-05
FR2640971B1 (en) 1994-04-29
GR1000460B (en) 1992-07-30
JPH02231469A (en) 1990-09-13
NL8903132A (en) 1990-07-16
IL92830A (en) 1994-12-29
GR890100859A (en) 1991-03-15
PH27571A (en) 1993-08-18
DK657089D0 (en) 1989-12-21
CA2006115A1 (en) 1990-06-23
GB2226313A (en) 1990-06-27
ATA290289A (en) 1993-11-15
IE59336B1 (en) 1994-02-09
IL92830A0 (en) 1990-09-17
IE894151L (en) 1990-06-23

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2009-12-21