ES2018414A6 - Process for obtaining enrofloxacin - Google Patents

Process for obtaining enrofloxacin

Info

Publication number
ES2018414A6
ES2018414A6 ES8903703A ES8903703A ES2018414A6 ES 2018414 A6 ES2018414 A6 ES 2018414A6 ES 8903703 A ES8903703 A ES 8903703A ES 8903703 A ES8903703 A ES 8903703A ES 2018414 A6 ES2018414 A6 ES 2018414A6
Authority
ES
Spain
Prior art keywords
enrofloxacin
obtaining
cyclopropyl
dihydro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903703A
Other languages
Spanish (es)
Inventor
Molina Isidro Lopez
Coto Antonio Domingo
Coll Alberto Palomo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Union Quimico Farmaceutica SA
Original Assignee
Union Quimico Farmaceutica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Quimico Farmaceutica SA filed Critical Union Quimico Farmaceutica SA
Priority to ES8903703A priority Critical patent/ES2018414A6/en
Publication of ES2018414A6 publication Critical patent/ES2018414A6/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

Process for obtaining enrofloxacin having the chemical name 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4- dihydro-4-oxoquinolin-3-carboxylic acid of formula I, its addition salts with pharmaceutically acceptable acids and its hydrates, based on the reaction of 3-acetyl-1- cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinolein, of formula V, < IMAGE > with an excess of N-ethylpiperazine and subsequent oxidation of the reaction product. Enrofloxacin is a bactericidal agent of proven effectiveness in the veterinary field in the prevention and treatment of infectious diseases.
ES8903703A 1989-11-02 1989-11-02 Process for obtaining enrofloxacin Expired - Lifetime ES2018414A6 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES8903703A ES2018414A6 (en) 1989-11-02 1989-11-02 Process for obtaining enrofloxacin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8903703A ES2018414A6 (en) 1989-11-02 1989-11-02 Process for obtaining enrofloxacin

Publications (1)

Publication Number Publication Date
ES2018414A6 true ES2018414A6 (en) 1991-04-01

Family

ID=8264642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903703A Expired - Lifetime ES2018414A6 (en) 1989-11-02 1989-11-02 Process for obtaining enrofloxacin

Country Status (1)

Country Link
ES (1) ES2018414A6 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2039301A1 (en) * 1991-11-20 1993-09-16 Genesis Para La Investigacion Fluoro:quinolone bactericide intermediate prepn.
ES2049640A1 (en) * 1992-06-18 1994-04-16 Genesis Para La Investigacion Substd quinoline carboxylic acid prepn useful for antibiotic prodn - by reacting acetophenone with alkane carboxylic acid chloride or anhydride, then with tri:methyl ortho:formate and amine, cyclising and oxidn

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2039301A1 (en) * 1991-11-20 1993-09-16 Genesis Para La Investigacion Fluoro:quinolone bactericide intermediate prepn.
ES2049640A1 (en) * 1992-06-18 1994-04-16 Genesis Para La Investigacion Substd quinoline carboxylic acid prepn useful for antibiotic prodn - by reacting acetophenone with alkane carboxylic acid chloride or anhydride, then with tri:methyl ortho:formate and amine, cyclising and oxidn

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Legal Events

Date Code Title Description
GC1A Exploitation certificate registered application without search report

Effective date: 19971020

FD1A Patent lapsed

Effective date: 20041103