ES2018414A6 - Process for obtaining enrofloxacin - Google Patents
Process for obtaining enrofloxacinInfo
- Publication number
- ES2018414A6 ES2018414A6 ES8903703A ES8903703A ES2018414A6 ES 2018414 A6 ES2018414 A6 ES 2018414A6 ES 8903703 A ES8903703 A ES 8903703A ES 8903703 A ES8903703 A ES 8903703A ES 2018414 A6 ES2018414 A6 ES 2018414A6
- Authority
- ES
- Spain
- Prior art keywords
- enrofloxacin
- obtaining
- cyclopropyl
- dihydro
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 title abstract 4
- 229960000740 enrofloxacin Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- WGCYRFWNGRMRJA-UHFFFAOYSA-N 1-ethylpiperazine Chemical compound CCN1CCNCC1 WGCYRFWNGRMRJA-UHFFFAOYSA-N 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Process for obtaining enrofloxacin having the chemical name 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4- dihydro-4-oxoquinolin-3-carboxylic acid of formula I, its addition salts with pharmaceutically acceptable acids and its hydrates, based on the reaction of 3-acetyl-1- cyclopropyl-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinolein, of formula V, < IMAGE > with an excess of N-ethylpiperazine and subsequent oxidation of the reaction product. Enrofloxacin is a bactericidal agent of proven effectiveness in the veterinary field in the prevention and treatment of infectious diseases.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8903703A ES2018414A6 (en) | 1989-11-02 | 1989-11-02 | Process for obtaining enrofloxacin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8903703A ES2018414A6 (en) | 1989-11-02 | 1989-11-02 | Process for obtaining enrofloxacin |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2018414A6 true ES2018414A6 (en) | 1991-04-01 |
Family
ID=8264642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8903703A Expired - Lifetime ES2018414A6 (en) | 1989-11-02 | 1989-11-02 | Process for obtaining enrofloxacin |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES2018414A6 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2039301A1 (en) * | 1991-11-20 | 1993-09-16 | Genesis Para La Investigacion | Fluoro:quinolone bactericide intermediate prepn. |
ES2049640A1 (en) * | 1992-06-18 | 1994-04-16 | Genesis Para La Investigacion | Substd quinoline carboxylic acid prepn useful for antibiotic prodn - by reacting acetophenone with alkane carboxylic acid chloride or anhydride, then with tri:methyl ortho:formate and amine, cyclising and oxidn |
-
1989
- 1989-11-02 ES ES8903703A patent/ES2018414A6/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2039301A1 (en) * | 1991-11-20 | 1993-09-16 | Genesis Para La Investigacion | Fluoro:quinolone bactericide intermediate prepn. |
ES2049640A1 (en) * | 1992-06-18 | 1994-04-16 | Genesis Para La Investigacion | Substd quinoline carboxylic acid prepn useful for antibiotic prodn - by reacting acetophenone with alkane carboxylic acid chloride or anhydride, then with tri:methyl ortho:formate and amine, cyclising and oxidn |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GC1A | Exploitation certificate registered application without search report |
Effective date: 19971020 |
|
FD1A | Patent lapsed |
Effective date: 20041103 |